9DVA

F-actin binding interface of alpha-E-catenin ABD (cadherin-catenin complex) and afadin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001725	cellular_component	stress fiber
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0048741	biological_process	skeletal muscle fiber development
B	0000166	molecular_function	nucleotide binding
B	0001725	cellular_component	stress fiber
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0048741	biological_process	skeletal muscle fiber development
C	0000166	molecular_function	nucleotide binding
C	0001725	cellular_component	stress fiber
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0048741	biological_process	skeletal muscle fiber development
D	0000166	molecular_function	nucleotide binding
D	0001725	cellular_component	stress fiber
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0048741	biological_process	skeletal muscle fiber development
E	0000166	molecular_function	nucleotide binding
E	0001725	cellular_component	stress fiber
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0048741	biological_process	skeletal muscle fiber development
F	0001541	biological_process	ovarian follicle development
F	0001669	cellular_component	acrosomal vesicle
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0005912	cellular_component	adherens junction
F	0005915	cellular_component	zonula adherens
F	0007155	biological_process	cell adhesion
F	0007163	biological_process	establishment or maintenance of cell polarity
F	0007406	biological_process	negative regulation of neuroblast proliferation
F	0008013	molecular_function	beta-catenin binding
F	0008092	molecular_function	cytoskeletal protein binding
F	0008104	biological_process	intracellular protein localization
F	0008584	biological_process	male gonad development
F	0014704	cellular_component	intercalated disc
F	0015629	cellular_component	actin cytoskeleton
F	0016264	biological_process	gap junction assembly
F	0016342	cellular_component	catenin complex
F	0016477	biological_process	cell migration
F	0016600	cellular_component	flotillin complex
F	0017166	molecular_function	vinculin binding
F	0030027	cellular_component	lamellipodium
F	0030054	cellular_component	cell junction
F	0031103	biological_process	axon regeneration
F	0042127	biological_process	regulation of cell population proliferation
F	0042475	biological_process	odontogenesis of dentin-containing tooth
F	0042802	molecular_function	identical protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0043297	biological_process	apical junction assembly
F	0043627	biological_process	response to estrogen
F	0044877	molecular_function	protein-containing complex binding
F	0045295	molecular_function	gamma-catenin binding
F	0045296	molecular_function	cadherin binding
F	0045880	biological_process	positive regulation of smoothened signaling pathway
F	0051015	molecular_function	actin filament binding
F	0070161	cellular_component	anchoring junction
F	0071681	biological_process	cellular response to indole-3-methanol
F	0090136	biological_process	epithelial cell-cell adhesion
F	0097225	cellular_component	sperm midpiece
F	0097228	cellular_component	sperm principal piece
F	0098609	biological_process	cell-cell adhesion
F	0098797	cellular_component	plasma membrane protein complex
F	0120212	cellular_component	sperm head-tail coupling apparatus
F	1900181	biological_process	negative regulation of protein localization to nucleus
F	2000146	biological_process	negative regulation of cell motility
F	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
F	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
F	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
G	0005911	cellular_component	cell-cell junction
H	0001541	biological_process	ovarian follicle development
H	0001669	cellular_component	acrosomal vesicle
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005915	cellular_component	zonula adherens
H	0007155	biological_process	cell adhesion
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007406	biological_process	negative regulation of neuroblast proliferation
H	0008013	molecular_function	beta-catenin binding
H	0008092	molecular_function	cytoskeletal protein binding
H	0008104	biological_process	intracellular protein localization
H	0008584	biological_process	male gonad development
H	0014704	cellular_component	intercalated disc
H	0015629	cellular_component	actin cytoskeleton
H	0016264	biological_process	gap junction assembly
H	0016342	cellular_component	catenin complex
H	0016477	biological_process	cell migration
H	0016600	cellular_component	flotillin complex
H	0017166	molecular_function	vinculin binding
H	0030027	cellular_component	lamellipodium
H	0030054	cellular_component	cell junction
H	0031103	biological_process	axon regeneration
H	0042127	biological_process	regulation of cell population proliferation
H	0042475	biological_process	odontogenesis of dentin-containing tooth
H	0042802	molecular_function	identical protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0043297	biological_process	apical junction assembly
H	0043627	biological_process	response to estrogen
H	0044877	molecular_function	protein-containing complex binding
H	0045295	molecular_function	gamma-catenin binding
H	0045296	molecular_function	cadherin binding
H	0045880	biological_process	positive regulation of smoothened signaling pathway
H	0051015	molecular_function	actin filament binding
H	0070161	cellular_component	anchoring junction
H	0071681	biological_process	cellular response to indole-3-methanol
H	0090136	biological_process	epithelial cell-cell adhesion
H	0097225	cellular_component	sperm midpiece
H	0097228	cellular_component	sperm principal piece
H	0098609	biological_process	cell-cell adhesion
H	0098797	cellular_component	plasma membrane protein complex
H	0120212	cellular_component	sperm head-tail coupling apparatus
H	1900181	biological_process	negative regulation of protein localization to nucleus
H	2000146	biological_process	negative regulation of cell motility
H	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
H	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
H	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS00663
Number of Residues	21
Details	VINCULIN_1 Vinculin family talin-binding region signature. KaLkpeVdkLnimaakRQQEL

Chain	Residue	Details
F	LYS178-LEU198

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"12356759","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MDU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	45
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35221","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P35221","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	38
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---