Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9DUQ

HURP(65-174) bound to GMPCPP-stabilized microtubule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003924	molecular_function	GTPase activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0001764	biological_process	neuron migration
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003924	molecular_function	GTPase activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0001764	biological_process	neuron migration
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003924	molecular_function	GTPase activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0015630	cellular_component	microtubule cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0001764	biological_process	neuron migration
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0016787	molecular_function	hydrolase activity
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0001764	biological_process	neuron migration
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0003924	molecular_function	GTPase activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0015630	cellular_component	microtubule cytoskeleton
M	0016787	molecular_function	hydrolase activity
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0001764	biological_process	neuron migration
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0046872	molecular_function	metal ion binding
O	0000166	molecular_function	nucleotide binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0003924	molecular_function	GTPase activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0007017	biological_process	microtubule-based process
O	0015630	cellular_component	microtubule cytoskeleton
O	0016787	molecular_function	hydrolase activity
O	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0001764	biological_process	neuron migration
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0016787	molecular_function	hydrolase activity
Q	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0001764	biological_process	neuron migration
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	GLU254
D	GLY144
D	THR145
D	GLY146
D	ASN206
D	ASN228
F	GLN11
F	SER140
F	GLY144
F	THR145
F	GLY146
C	GLU254
F	ASN206
F	ASN228
H	GLN11
H	SER140
H	GLY144
H	THR145
H	GLY146
H	ASN206
H	ASN228
J	GLN11
E	GLU254
J	SER140
J	GLY144
J	THR145
J	GLY146
J	ASN206
J	ASN228
L	GLN11
L	SER140
L	GLY144
L	THR145
G	GLU254
L	GLY146
L	ASN206
L	ASN228
N	GLN11
N	SER140
N	GLY144
N	THR145
N	GLY146
N	ASN206
N	ASN228
I	GLU254
P	GLN11
P	SER140
P	GLY144
P	THR145
P	GLY146
P	ASN206
P	ASN228
R	GLN11
R	SER140
R	GLY144
K	GLU254
R	THR145
R	GLY146
R	ASN206
R	ASN228
M	GLU254
O	GLU254
Q	GLU254

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	GLN11
C	GLU71
C	SER140
C	GLY144
C	THR145
C	THR179
C	ASN206
C	ASN228
E	GLN11
E	GLU71
E	SER140
A	GLU71
E	GLY144
E	THR145
E	THR179
E	ASN206
E	ASN228
G	GLN11
G	GLU71
G	SER140
G	GLY144
G	THR145
A	SER140
G	THR179
G	ASN206
G	ASN228
I	GLN11
I	GLU71
I	SER140
I	GLY144
I	THR145
I	THR179
I	ASN206
A	GLY144
I	ASN228
K	GLN11
K	GLU71
K	SER140
K	GLY144
K	THR145
K	THR179
K	ASN206
K	ASN228
M	GLN11
A	THR145
M	GLU71
M	SER140
M	GLY144
M	THR145
M	THR179
M	ASN206
M	ASN228
O	GLN11
O	GLU71
O	SER140
A	THR179
O	GLY144
O	THR145
O	THR179
O	ASN206
O	ASN228
Q	GLN11
Q	GLU71
Q	SER140
Q	GLY144
Q	THR145
A	ASN206
Q	THR179
Q	ASN206
Q	ASN228
A	ASN228
C	GLN11

site_id	SWS_FT_FI3
Number of Residues	9
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	LYS40
C	LYS40
E	LYS40
G	LYS40
I	LYS40
K	LYS40
M	LYS40
O	LYS40
Q	LYS40

site_id	SWS_FT_FI4
Number of Residues	18
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	SER48
I	SER232
K	SER48
K	SER232
M	SER48
M	SER232
O	SER48
O	SER232
Q	SER48
Q	SER232
A	SER232
C	SER48
C	SER232
E	SER48
E	SER232
G	SER48
G	SER232
I	SER48

site_id	SWS_FT_FI5
Number of Residues	9
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
A	TYR282
C	TYR282
E	TYR282
G	TYR282
I	TYR282
K	TYR282
M	TYR282
O	TYR282
Q	TYR282

site_id	SWS_FT_FI6
Number of Residues	9
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	ARG339
J	THR292
L	THR287
L	THR292
N	THR287
N	THR292
P	THR287
P	THR292
R	THR287
R	THR292
C	ARG339
E	ARG339
G	ARG339
I	ARG339
K	ARG339
M	ARG339
O	ARG339
Q	ARG339

site_id	SWS_FT_FI7
Number of Residues	9
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
A	SER439
C	SER439
E	SER439
G	SER439
I	SER439
K	SER439
M	SER439
O	SER439
Q	SER439

site_id	SWS_FT_FI8
Number of Residues	27
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
A	LYS326
G	LYS326
G	LYS370
I	LYS326
I	LYS370
K	LYS326
K	LYS370
M	LYS326
D	LYS60
M	LYS370
O	LYS326
O	LYS370
Q	LYS326
Q	LYS370
A	LYS370
C	LYS326
J	LYS60
C	LYS370
E	LYS326
P	LYS60
E	LYS370

site_id	SWS_FT_FI9
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
J	LYS326
L	LYS326
N	LYS326
P	LYS326
R	LYS326
B	LYS326
D	LYS326
F	LYS326
H	LYS326

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)