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9DNX

Human ClC-3:TMEM9, TMEM9 Protomer A and B: Complete

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0005247molecular_functionvoltage-gated chloride channel activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006885biological_processregulation of pH
A0006911biological_processphagocytosis, engulfment
A0008021cellular_componentsynaptic vesicle
A0008344biological_processadult locomotory behavior
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010008cellular_componentendosome membrane
A0012506cellular_componentvesicle membrane
A0015297molecular_functionantiporter activity
A0016020cellular_componentmembrane
A0030141cellular_componentsecretory granule
A0030165molecular_functionPDZ domain binding
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032587cellular_componentruffle membrane
A0035249biological_processsynaptic transmission, glutamatergic
A0042581cellular_componentspecific granule
A0042995cellular_componentcell projection
A0043679cellular_componentaxon terminus
A0045335cellular_componentphagocytic vesicle
A0045494biological_processphotoreceptor cell maintenance
A0045794biological_processnegative regulation of cell volume
A0048388biological_processendosomal lumen acidification
A0051932biological_processsynaptic transmission, GABAergic
A0055037cellular_componentrecycling endosome
A0070050biological_processneuron cellular homeostasis
A0072320molecular_functionvolume-sensitive chloride channel activity
A0097401biological_processsynaptic vesicle lumen acidification
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A1902476biological_processchloride transmembrane transport
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0005247molecular_functionvoltage-gated chloride channel activity
C0005254molecular_functionchloride channel activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005770cellular_componentlate endosome
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006885biological_processregulation of pH
C0006911biological_processphagocytosis, engulfment
C0008021cellular_componentsynaptic vesicle
C0008344biological_processadult locomotory behavior
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010008cellular_componentendosome membrane
C0012506cellular_componentvesicle membrane
C0015297molecular_functionantiporter activity
C0016020cellular_componentmembrane
C0030141cellular_componentsecretory granule
C0030165molecular_functionPDZ domain binding
C0030672cellular_componentsynaptic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031901cellular_componentearly endosome membrane
C0031902cellular_componentlate endosome membrane
C0032587cellular_componentruffle membrane
C0035249biological_processsynaptic transmission, glutamatergic
C0042581cellular_componentspecific granule
C0042995cellular_componentcell projection
C0043679cellular_componentaxon terminus
C0045335cellular_componentphagocytic vesicle
C0045494biological_processphotoreceptor cell maintenance
C0045794biological_processnegative regulation of cell volume
C0048388biological_processendosomal lumen acidification
C0051932biological_processsynaptic transmission, GABAergic
C0055037cellular_componentrecycling endosome
C0070050biological_processneuron cellular homeostasis
C0072320molecular_functionvolume-sensitive chloride channel activity
C0097401biological_processsynaptic vesicle lumen acidification
C0098978cellular_componentglutamatergic synapse
C0098982cellular_componentGABA-ergic synapse
C1902476biological_processchloride transmembrane transport
C1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues136
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
DASN21-LYS89
BASN21-LYS89
CMET1-ALA125
CGLY625-ASN818

site_idSWS_FT_FI2
Number of Residues40
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
DVAL90-MET110
ATYR606-PHE624
CTRP126-SER163
CMET209-PHE232
CGLY258-GLY276
CGLU282-PRO301
CLEU349-ASN367
CPHE391-ARG416
CPHE423-PHE443
CILE500-ILE520
CGLY525-ALA544
BVAL90-MET110
CTYR606-PHE624
AGLY258-GLY276
AGLU282-PRO301
ALEU349-ASN367
APHE391-ARG416
APHE423-PHE443
AILE500-ILE520
AGLY525-ALA544

site_idSWS_FT_FI3
Number of Residues144
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
DLEU111-SER183
CTHR590-THR601
BLEU111-SER183
APRO329-LEU337
AGLY572-VAL586
ATHR590-THR601
CILE241-LEU248
CVAL313-ALA325
CPRO329-LEU337
CGLY572-VAL586

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER137
BSER137

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER144
CTHR796
BSER144
ATYR630
ATYR689
ATHR796
CSER239
CPHE527
CTYR630
CTYR689

site_idSWS_FT_FI6
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN21
DASN38
DASN47
BASN21
BASN38
BASN47

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Mediates proton transfer from the protein to the inner aqueous phase => ECO:0000250
ChainResidueDetails
AGLU339
CGLU339

site_idSWS_FT_FI8
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN177
AASN451
AASN479
CASN177
CASN451
CASN479

237735

PDB entries from 2025-06-18

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