9DDW

Cryo-EM structure of the human P2X2 receptor in conformation I of the ATP-bound desensitized state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001614	molecular_function	purinergic nucleotide receptor activity
A	0002931	biological_process	response to ischemia
A	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0007605	biological_process	sensory perception of sound
A	0010524	biological_process	positive regulation of calcium ion transport into cytosol
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016324	cellular_component	apical plasma membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043235	cellular_component	receptor complex
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0060079	biological_process	excitatory postsynaptic potential
A	0070588	biological_process	calcium ion transmembrane transport
A	0098794	cellular_component	postsynapse
A	0098992	cellular_component	neuronal dense core vesicle
B	0000166	molecular_function	nucleotide binding
B	0001614	molecular_function	purinergic nucleotide receptor activity
B	0002931	biological_process	response to ischemia
B	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0007605	biological_process	sensory perception of sound
B	0010524	biological_process	positive regulation of calcium ion transport into cytosol
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016324	cellular_component	apical plasma membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035590	biological_process	purinergic nucleotide receptor signaling pathway
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043235	cellular_component	receptor complex
B	0050850	biological_process	positive regulation of calcium-mediated signaling
B	0060079	biological_process	excitatory postsynaptic potential
B	0070588	biological_process	calcium ion transmembrane transport
B	0098794	cellular_component	postsynapse
B	0098992	cellular_component	neuronal dense core vesicle
C	0000166	molecular_function	nucleotide binding
C	0001614	molecular_function	purinergic nucleotide receptor activity
C	0002931	biological_process	response to ischemia
C	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0007605	biological_process	sensory perception of sound
C	0010524	biological_process	positive regulation of calcium ion transport into cytosol
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016324	cellular_component	apical plasma membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035590	biological_process	purinergic nucleotide receptor signaling pathway
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043235	cellular_component	receptor complex
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0060079	biological_process	excitatory postsynaptic potential
C	0070588	biological_process	calcium ion transmembrane transport
C	0098794	cellular_component	postsynapse
C	0098992	cellular_component	neuronal dense core vesicle

Functional Information from PROSITE/UniProt

site_id	PS01212
Number of Residues	27
Details	P2X_RECEPTOR ATP P2X receptors signature. GGvIGViInWdCDLDlpaseCnPkYsF

Chain	Residue	Details
A	GLY259-PHE285

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	819
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Region: {"description":"Pore-forming motif","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---