9DA8

Tau-Microtubule structure in the presence of ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0001764	biological_process	neuron migration
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0001764	biological_process	neuron migration
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0046872	molecular_function	metal ion binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0001774	biological_process	microglial cell activation
D	0003677	molecular_function	DNA binding
D	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003723	molecular_function	RNA binding
D	0003779	molecular_function	actin binding
D	0004857	molecular_function	enzyme inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005886	cellular_component	plasma membrane
D	0006974	biological_process	DNA damage response
D	0007267	biological_process	cell-cell signaling
D	0007613	biological_process	memory
D	0008017	molecular_function	microtubule binding
D	0010288	biological_process	response to lead ion
D	0010506	biological_process	regulation of autophagy
D	0010629	biological_process	negative regulation of gene expression
D	0010917	biological_process	negative regulation of mitochondrial membrane potential
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016072	biological_process	rRNA metabolic process
D	0017124	molecular_function	SH3 domain binding
D	0019896	biological_process	axonal transport of mitochondrion
D	0019899	molecular_function	enzyme binding
D	0019901	molecular_function	protein kinase binding
D	0021954	biological_process	central nervous system neuron development
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0030673	cellular_component	axolemma
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031110	biological_process	regulation of microtubule polymerization or depolymerization
D	0031113	biological_process	regulation of microtubule polymerization
D	0031116	biological_process	positive regulation of microtubule polymerization
D	0031122	biological_process	cytoplasmic microtubule organization
D	0031175	biological_process	neuron projection development
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0033044	biological_process	regulation of chromosome organization
D	0034063	biological_process	stress granule assembly
D	0034185	molecular_function	apolipoprotein binding
D	0034399	cellular_component	nuclear periphery
D	0034452	molecular_function	dynactin binding
D	0034605	biological_process	cellular response to heat
D	0034614	biological_process	cellular response to reactive oxygen species
D	0035091	molecular_function	phosphatidylinositol binding
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0036477	cellular_component	somatodendritic compartment
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0043565	molecular_function	sequence-specific DNA binding
D	0044297	cellular_component	cell body
D	0044304	cellular_component	main axon
D	0045121	cellular_component	membrane raft
D	0045298	cellular_component	tubulin complex
D	0045773	biological_process	positive regulation of axon extension
D	0046785	biological_process	microtubule polymerization
D	0048143	biological_process	astrocyte activation
D	0048167	biological_process	regulation of synaptic plasticity
D	0048312	biological_process	intracellular distribution of mitochondria
D	0048699	biological_process	generation of neurons
D	0050808	biological_process	synapse organization
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0051087	molecular_function	protein-folding chaperone binding
D	0051258	biological_process	protein polymerization
D	0051721	molecular_function	protein phosphatase 2A binding
D	0051879	molecular_function	Hsp90 protein binding
D	0060632	biological_process	regulation of microtubule-based movement
D	0061564	biological_process	axon development
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0071813	molecular_function	lipoprotein particle binding
D	0072386	biological_process	plus-end-directed organelle transport along microtubule
D	0090140	biological_process	regulation of mitochondrial fission
D	0090258	biological_process	negative regulation of mitochondrial fission
D	0097386	cellular_component	glial cell projection
D	0097418	cellular_component	neurofibrillary tangle
D	0097435	biological_process	supramolecular fiber organization
D	0098930	biological_process	axonal transport
D	0099077	molecular_function	histone-dependent DNA binding
D	0099609	molecular_function	microtubule lateral binding
D	1900034	biological_process	regulation of cellular response to heat
D	1900452	biological_process	regulation of long-term synaptic depression
D	1902474	biological_process	positive regulation of protein localization to synapse
D	1902936	molecular_function	phosphatidylinositol bisphosphate binding
D	1902988	biological_process	neurofibrillary tangle assembly
D	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
D	1903829	biological_process	positive regulation of protein localization
D	1904115	cellular_component	axon cytoplasm
D	1990000	biological_process	amyloid fibril formation
D	1990090	biological_process	cellular response to nerve growth factor stimulus
D	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0001764	biological_process	neuron migration
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0015630	cellular_component	microtubule cytoskeleton
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0001764	biological_process	neuron migration
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0046872	molecular_function	metal ion binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0001774	biological_process	microglial cell activation
N	0003677	molecular_function	DNA binding
N	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
N	0003690	molecular_function	double-stranded DNA binding
N	0003697	molecular_function	single-stranded DNA binding
N	0003723	molecular_function	RNA binding
N	0003779	molecular_function	actin binding
N	0004857	molecular_function	enzyme inhibitor activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0005886	cellular_component	plasma membrane
N	0006974	biological_process	DNA damage response
N	0007267	biological_process	cell-cell signaling
N	0007613	biological_process	memory
N	0008017	molecular_function	microtubule binding
N	0010288	biological_process	response to lead ion
N	0010506	biological_process	regulation of autophagy
N	0010629	biological_process	negative regulation of gene expression
N	0010917	biological_process	negative regulation of mitochondrial membrane potential
N	0015630	cellular_component	microtubule cytoskeleton
N	0016020	cellular_component	membrane
N	0016072	biological_process	rRNA metabolic process
N	0017124	molecular_function	SH3 domain binding
N	0019896	biological_process	axonal transport of mitochondrion
N	0019899	molecular_function	enzyme binding
N	0019901	molecular_function	protein kinase binding
N	0021954	biological_process	central nervous system neuron development
N	0030424	cellular_component	axon
N	0030425	cellular_component	dendrite
N	0030426	cellular_component	growth cone
N	0030673	cellular_component	axolemma
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0031110	biological_process	regulation of microtubule polymerization or depolymerization
N	0031113	biological_process	regulation of microtubule polymerization
N	0031116	biological_process	positive regulation of microtubule polymerization
N	0031122	biological_process	cytoplasmic microtubule organization
N	0031175	biological_process	neuron projection development
N	0032930	biological_process	positive regulation of superoxide anion generation
N	0033044	biological_process	regulation of chromosome organization
N	0034063	biological_process	stress granule assembly
N	0034185	molecular_function	apolipoprotein binding
N	0034399	cellular_component	nuclear periphery
N	0034452	molecular_function	dynactin binding
N	0034605	biological_process	cellular response to heat
N	0034614	biological_process	cellular response to reactive oxygen species
N	0035091	molecular_function	phosphatidylinositol binding
N	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
N	0036477	cellular_component	somatodendritic compartment
N	0042802	molecular_function	identical protein binding
N	0043005	cellular_component	neuron projection
N	0043025	cellular_component	neuronal cell body
N	0043197	cellular_component	dendritic spine
N	0043565	molecular_function	sequence-specific DNA binding
N	0044297	cellular_component	cell body
N	0044304	cellular_component	main axon
N	0045121	cellular_component	membrane raft
N	0045298	cellular_component	tubulin complex
N	0045773	biological_process	positive regulation of axon extension
N	0046785	biological_process	microtubule polymerization
N	0048143	biological_process	astrocyte activation
N	0048167	biological_process	regulation of synaptic plasticity
N	0048312	biological_process	intracellular distribution of mitochondria
N	0048699	biological_process	generation of neurons
N	0050808	biological_process	synapse organization
N	0050848	biological_process	regulation of calcium-mediated signaling
N	0051087	molecular_function	protein-folding chaperone binding
N	0051258	biological_process	protein polymerization
N	0051721	molecular_function	protein phosphatase 2A binding
N	0051879	molecular_function	Hsp90 protein binding
N	0060632	biological_process	regulation of microtubule-based movement
N	0061564	biological_process	axon development
N	0070507	biological_process	regulation of microtubule cytoskeleton organization
N	0071813	molecular_function	lipoprotein particle binding
N	0072386	biological_process	plus-end-directed organelle transport along microtubule
N	0090140	biological_process	regulation of mitochondrial fission
N	0090258	biological_process	negative regulation of mitochondrial fission
N	0097386	cellular_component	glial cell projection
N	0097418	cellular_component	neurofibrillary tangle
N	0097435	biological_process	supramolecular fiber organization
N	0098930	biological_process	axonal transport
N	0099077	molecular_function	histone-dependent DNA binding
N	0099609	molecular_function	microtubule lateral binding
N	1900034	biological_process	regulation of cellular response to heat
N	1900452	biological_process	regulation of long-term synaptic depression
N	1902474	biological_process	positive regulation of protein localization to synapse
N	1902936	molecular_function	phosphatidylinositol bisphosphate binding
N	1902988	biological_process	neurofibrillary tangle assembly
N	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
N	1903829	biological_process	positive regulation of protein localization
N	1904115	cellular_component	axon cytoplasm
N	1990000	biological_process	amyloid fibril formation
N	1990090	biological_process	cellular response to nerve growth factor stimulus
N	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY140-GLY146

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
A	MET1-ILE4

---

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
D	GLY261-GLY273
D	GLY292-GLY304
D	GLY323-GLY335
D	GLY355-GLY367

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Deamidated asparagine; in tau and PHF-tau; partial","evidences":[{"source":"PubMed","id":"1512244","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---