9D8P

Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0016567	biological_process	protein ubiquitination
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0032874	biological_process	positive regulation of stress-activated MAPK cascade
A	0072344	biological_process	rescue of stalled ribosome
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0000151	cellular_component	ubiquitin ligase complex
B	0001222	molecular_function	transcription corepressor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0016567	biological_process	protein ubiquitination
B	0030891	cellular_component	VCB complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0070449	cellular_component	elongin complex
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0140958	biological_process	target-directed miRNA degradation
C	0000151	cellular_component	ubiquitin ligase complex
C	0001222	molecular_function	transcription corepressor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0070449	cellular_component	elongin complex
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0140958	biological_process	target-directed miRNA degradation

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGcqleD

Chain	Residue	Details
D	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	67
Details	Repeat: {"description":"Kelch 1","evidences":[{"source":"PubMed","id":"39548056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	43
Details	Repeat: {"description":"Kelch 2","evidences":[{"source":"PubMed","id":"39548056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	58
Details	Repeat: {"description":"Kelch 4","evidences":[{"source":"PubMed","id":"39548056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	44
Details	Repeat: {"description":"Kelch 5","evidences":[{"source":"PubMed","id":"39548056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	38
Details	Repeat: {"description":"Kelch 6","evidences":[{"source":"PubMed","id":"39548056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9D8P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	41
Details	Region: {"description":"Interaction with CUL2","evidences":[{"source":"PubMed","id":"23102700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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