9D4B

Discovery of SMD-3236, a Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0030891	cellular_component	VCB complex
B	0070449	cellular_component	elongin complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0030891	cellular_component	VCB complex
E	0070449	cellular_component	elongin complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006338	biological_process	chromatin remodeling
G	0016586	cellular_component	RSC-type complex
H	0006338	biological_process	chromatin remodeling
H	0016586	cellular_component	RSC-type complex

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF

Chain	Residue	Details
G	SER1406-PHE1463

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	130
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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