Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9D49

Atomic model of triple mutant S. cerevisiae Fatty Acid Synthase (FAS) in complex with Palmitoyl-CoA (in vitro binding)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004312	molecular_function	fatty acid synthase activity
A	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
A	0016409	molecular_function	palmitoyltransferase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0003824	molecular_function	catalytic activity
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0004312	molecular_function	fatty acid synthase activity
E	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
E	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
E	0016409	molecular_function	palmitoyltransferase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0003824	molecular_function	catalytic activity
F	0004312	molecular_function	fatty acid synthase activity
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0004321	molecular_function	fatty-acyl-CoA synthase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005835	cellular_component	fatty acid synthase complex
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0046872	molecular_function	metal ion binding
I	0003824	molecular_function	catalytic activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0016787	molecular_function	hydrolase activity
I	0016829	molecular_function	lyase activity
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0003824	molecular_function	catalytic activity
J	0004312	molecular_function	fatty acid synthase activity
J	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
J	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0004321	molecular_function	fatty-acyl-CoA synthase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005835	cellular_component	fatty acid synthase complex
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
J	0016491	molecular_function	oxidoreductase activity
J	0016740	molecular_function	transferase activity
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0046872	molecular_function	metal ion binding
M	0003824	molecular_function	catalytic activity
M	0004312	molecular_function	fatty acid synthase activity
M	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
M	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
M	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M	0004321	molecular_function	fatty-acyl-CoA synthase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005811	cellular_component	lipid droplet
M	0005829	cellular_component	cytosol
M	0005835	cellular_component	fatty acid synthase complex
M	0006629	biological_process	lipid metabolic process
M	0006631	biological_process	fatty acid metabolic process
M	0006633	biological_process	fatty acid biosynthetic process
M	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
M	0016409	molecular_function	palmitoyltransferase activity
M	0016491	molecular_function	oxidoreductase activity
M	0016740	molecular_function	transferase activity
M	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
M	0016787	molecular_function	hydrolase activity
M	0016829	molecular_function	lyase activity
M	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
M	0042759	biological_process	long-chain fatty acid biosynthetic process
M	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
N	0003824	molecular_function	catalytic activity
N	0004312	molecular_function	fatty acid synthase activity
N	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
N	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
N	0004321	molecular_function	fatty-acyl-CoA synthase activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005835	cellular_component	fatty acid synthase complex
N	0006629	biological_process	lipid metabolic process
N	0006631	biological_process	fatty acid metabolic process
N	0006633	biological_process	fatty acid biosynthetic process
N	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
N	0016491	molecular_function	oxidoreductase activity
N	0016740	molecular_function	transferase activity
N	0042759	biological_process	long-chain fatty acid biosynthetic process
N	0046872	molecular_function	metal ion binding
Q	0003824	molecular_function	catalytic activity
Q	0004312	molecular_function	fatty acid synthase activity
Q	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
Q	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
Q	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Q	0004321	molecular_function	fatty-acyl-CoA synthase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005811	cellular_component	lipid droplet
Q	0005829	cellular_component	cytosol
Q	0005835	cellular_component	fatty acid synthase complex
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
Q	0016409	molecular_function	palmitoyltransferase activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016740	molecular_function	transferase activity
Q	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
Q	0016787	molecular_function	hydrolase activity
Q	0016829	molecular_function	lyase activity
Q	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Q	0042759	biological_process	long-chain fatty acid biosynthetic process
Q	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
R	0003824	molecular_function	catalytic activity
R	0004312	molecular_function	fatty acid synthase activity
R	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
R	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
R	0004321	molecular_function	fatty-acyl-CoA synthase activity
R	0005515	molecular_function	protein binding
R	0005739	cellular_component	mitochondrion
R	0005829	cellular_component	cytosol
R	0005835	cellular_component	fatty acid synthase complex
R	0006629	biological_process	lipid metabolic process
R	0006631	biological_process	fatty acid metabolic process
R	0006633	biological_process	fatty acid biosynthetic process
R	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
R	0016491	molecular_function	oxidoreductase activity
R	0016740	molecular_function	transferase activity
R	0042759	biological_process	long-chain fatty acid biosynthetic process
R	0046872	molecular_function	metal ion binding
U	0003824	molecular_function	catalytic activity
U	0004312	molecular_function	fatty acid synthase activity
U	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
U	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
U	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U	0004321	molecular_function	fatty-acyl-CoA synthase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005739	cellular_component	mitochondrion
U	0005811	cellular_component	lipid droplet
U	0005829	cellular_component	cytosol
U	0005835	cellular_component	fatty acid synthase complex
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
U	0016409	molecular_function	palmitoyltransferase activity
U	0016491	molecular_function	oxidoreductase activity
U	0016740	molecular_function	transferase activity
U	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
U	0016787	molecular_function	hydrolase activity
U	0016829	molecular_function	lyase activity
U	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
U	0042759	biological_process	long-chain fatty acid biosynthetic process
U	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
V	0003824	molecular_function	catalytic activity
V	0004312	molecular_function	fatty acid synthase activity
V	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
V	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
V	0004321	molecular_function	fatty-acyl-CoA synthase activity
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005829	cellular_component	cytosol
V	0005835	cellular_component	fatty acid synthase complex
V	0006629	biological_process	lipid metabolic process
V	0006631	biological_process	fatty acid metabolic process
V	0006633	biological_process	fatty acid biosynthetic process
V	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
V	0016491	molecular_function	oxidoreductase activity
V	0016740	molecular_function	transferase activity
V	0042759	biological_process	long-chain fatty acid biosynthetic process
V	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
B	LEU175-LEU190

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
B	GLY1296-VAL1312

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	750
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2328
Details	Region: {"description":"Enoyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2892
Details	Region: {"description":"Dehydratase"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1308
Details	Region: {"description":"Malonyl/palmitoyl transferase"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3204
Details	Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1194
Details	Region: {"description":"Beta-ketoacyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)