9D47

Atomic model of Candida albicans Fatty Acid Synthase (FAS) in complex with Palmitoyl-CoA (in vitro binding)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004312	molecular_function	fatty acid synthase activity
A	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
A	0016409	molecular_function	palmitoyltransferase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0003824	molecular_function	catalytic activity
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005829	cellular_component	cytosol
C	0005835	cellular_component	fatty acid synthase complex
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0101026	biological_process	mitotic nuclear membrane biogenesis
C	1900535	biological_process	palmitic acid biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0004312	molecular_function	fatty acid synthase activity
E	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
E	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
E	0016409	molecular_function	palmitoyltransferase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
G	0003824	molecular_function	catalytic activity
G	0004312	molecular_function	fatty acid synthase activity
G	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
G	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0101026	biological_process	mitotic nuclear membrane biogenesis
G	1900535	biological_process	palmitic acid biosynthetic process
I	0003824	molecular_function	catalytic activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0016787	molecular_function	hydrolase activity
I	0016829	molecular_function	lyase activity
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0003824	molecular_function	catalytic activity
K	0004312	molecular_function	fatty acid synthase activity
K	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
K	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0004321	molecular_function	fatty-acyl-CoA synthase activity
K	0005829	cellular_component	cytosol
K	0005835	cellular_component	fatty acid synthase complex
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0006633	biological_process	fatty acid biosynthetic process
K	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
K	0016491	molecular_function	oxidoreductase activity
K	0016740	molecular_function	transferase activity
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0046872	molecular_function	metal ion binding
K	0101026	biological_process	mitotic nuclear membrane biogenesis
K	1900535	biological_process	palmitic acid biosynthetic process
M	0003824	molecular_function	catalytic activity
M	0004312	molecular_function	fatty acid synthase activity
M	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
M	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
M	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M	0004321	molecular_function	fatty-acyl-CoA synthase activity
M	0005811	cellular_component	lipid droplet
M	0005829	cellular_component	cytosol
M	0005835	cellular_component	fatty acid synthase complex
M	0006629	biological_process	lipid metabolic process
M	0006631	biological_process	fatty acid metabolic process
M	0006633	biological_process	fatty acid biosynthetic process
M	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
M	0016409	molecular_function	palmitoyltransferase activity
M	0016491	molecular_function	oxidoreductase activity
M	0016740	molecular_function	transferase activity
M	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
M	0016787	molecular_function	hydrolase activity
M	0016829	molecular_function	lyase activity
M	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
M	0042759	biological_process	long-chain fatty acid biosynthetic process
M	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
O	0003824	molecular_function	catalytic activity
O	0004312	molecular_function	fatty acid synthase activity
O	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
O	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
O	0004321	molecular_function	fatty-acyl-CoA synthase activity
O	0005829	cellular_component	cytosol
O	0005835	cellular_component	fatty acid synthase complex
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0006633	biological_process	fatty acid biosynthetic process
O	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
O	0016491	molecular_function	oxidoreductase activity
O	0016740	molecular_function	transferase activity
O	0042759	biological_process	long-chain fatty acid biosynthetic process
O	0046872	molecular_function	metal ion binding
O	0101026	biological_process	mitotic nuclear membrane biogenesis
O	1900535	biological_process	palmitic acid biosynthetic process
Q	0003824	molecular_function	catalytic activity
Q	0004312	molecular_function	fatty acid synthase activity
Q	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
Q	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
Q	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Q	0004321	molecular_function	fatty-acyl-CoA synthase activity
Q	0005811	cellular_component	lipid droplet
Q	0005829	cellular_component	cytosol
Q	0005835	cellular_component	fatty acid synthase complex
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
Q	0016409	molecular_function	palmitoyltransferase activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016740	molecular_function	transferase activity
Q	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
Q	0016787	molecular_function	hydrolase activity
Q	0016829	molecular_function	lyase activity
Q	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Q	0042759	biological_process	long-chain fatty acid biosynthetic process
Q	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
S	0003824	molecular_function	catalytic activity
S	0004312	molecular_function	fatty acid synthase activity
S	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
S	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
S	0004321	molecular_function	fatty-acyl-CoA synthase activity
S	0005829	cellular_component	cytosol
S	0005835	cellular_component	fatty acid synthase complex
S	0006629	biological_process	lipid metabolic process
S	0006631	biological_process	fatty acid metabolic process
S	0006633	biological_process	fatty acid biosynthetic process
S	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
S	0016491	molecular_function	oxidoreductase activity
S	0016740	molecular_function	transferase activity
S	0042759	biological_process	long-chain fatty acid biosynthetic process
S	0046872	molecular_function	metal ion binding
S	0101026	biological_process	mitotic nuclear membrane biogenesis
S	1900535	biological_process	palmitic acid biosynthetic process
U	0003824	molecular_function	catalytic activity
U	0004312	molecular_function	fatty acid synthase activity
U	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
U	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
U	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U	0004321	molecular_function	fatty-acyl-CoA synthase activity
U	0005811	cellular_component	lipid droplet
U	0005829	cellular_component	cytosol
U	0005835	cellular_component	fatty acid synthase complex
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
U	0016409	molecular_function	palmitoyltransferase activity
U	0016491	molecular_function	oxidoreductase activity
U	0016740	molecular_function	transferase activity
U	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
U	0016787	molecular_function	hydrolase activity
U	0016829	molecular_function	lyase activity
U	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
U	0042759	biological_process	long-chain fatty acid biosynthetic process
U	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
X	0003824	molecular_function	catalytic activity
X	0004312	molecular_function	fatty acid synthase activity
X	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
X	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
X	0004321	molecular_function	fatty-acyl-CoA synthase activity
X	0005829	cellular_component	cytosol
X	0005835	cellular_component	fatty acid synthase complex
X	0006629	biological_process	lipid metabolic process
X	0006631	biological_process	fatty acid metabolic process
X	0006633	biological_process	fatty acid biosynthetic process
X	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
X	0016491	molecular_function	oxidoreductase activity
X	0016740	molecular_function	transferase activity
X	0042759	biological_process	long-chain fatty acid biosynthetic process
X	0046872	molecular_function	metal ion binding
X	0101026	biological_process	mitotic nuclear membrane biogenesis
X	1900535	biological_process	palmitic acid biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVNGKSTVQNEILGDL

Chain	Residue	Details
C	LEU176-LEU191

---

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSV

Chain	Residue	Details
C	GLY1295-VAL1311

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	768
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1998
Details	Region: {"description":"Enoyl reductase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---