9CYY

Cryo-EM structure of MRV virion

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0019028	cellular_component	viral capsid
0	0039625	cellular_component	viral inner capsid
0	0044423	cellular_component	virion component
a	0000166	molecular_function	nucleotide binding
a	0003724	molecular_function	RNA helicase activity
a	0004386	molecular_function	helicase activity
a	0005524	molecular_function	ATP binding
a	0006370	biological_process	7-methylguanosine mRNA capping
a	0006397	biological_process	mRNA processing
a	0008270	molecular_function	zinc ion binding
a	0016787	molecular_function	hydrolase activity
a	0016887	molecular_function	ATP hydrolysis activity
a	0019028	cellular_component	viral capsid
a	0039616	cellular_component	T=2 icosahedral viral capsid
a	0039625	cellular_component	viral inner capsid
a	0044423	cellular_component	virion component
a	0046872	molecular_function	metal ion binding
A	0019028	cellular_component	viral capsid
A	0020002	cellular_component	host cell plasma membrane
A	0033650	cellular_component	host cell mitochondrion
A	0039624	cellular_component	viral outer capsid
A	0044165	cellular_component	host cell endoplasmic reticulum
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046812	molecular_function	host cell surface binding
A	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
b	0000166	molecular_function	nucleotide binding
b	0003724	molecular_function	RNA helicase activity
b	0004386	molecular_function	helicase activity
b	0005524	molecular_function	ATP binding
b	0006370	biological_process	7-methylguanosine mRNA capping
b	0006397	biological_process	mRNA processing
b	0008270	molecular_function	zinc ion binding
b	0016787	molecular_function	hydrolase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0019028	cellular_component	viral capsid
b	0039616	cellular_component	T=2 icosahedral viral capsid
b	0039625	cellular_component	viral inner capsid
b	0044423	cellular_component	virion component
b	0046872	molecular_function	metal ion binding
B	0019028	cellular_component	viral capsid
B	0020002	cellular_component	host cell plasma membrane
B	0033650	cellular_component	host cell mitochondrion
B	0039624	cellular_component	viral outer capsid
B	0044165	cellular_component	host cell endoplasmic reticulum
B	0044423	cellular_component	virion component
B	0046718	biological_process	symbiont entry into host cell
B	0046812	molecular_function	host cell surface binding
B	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
c	0000166	molecular_function	nucleotide binding
c	0003724	molecular_function	RNA helicase activity
c	0004386	molecular_function	helicase activity
c	0005524	molecular_function	ATP binding
c	0006370	biological_process	7-methylguanosine mRNA capping
c	0006397	biological_process	mRNA processing
c	0008270	molecular_function	zinc ion binding
c	0016787	molecular_function	hydrolase activity
c	0016887	molecular_function	ATP hydrolysis activity
c	0019028	cellular_component	viral capsid
c	0039616	cellular_component	T=2 icosahedral viral capsid
c	0039625	cellular_component	viral inner capsid
c	0044423	cellular_component	virion component
c	0046872	molecular_function	metal ion binding
C	0019028	cellular_component	viral capsid
C	0039625	cellular_component	viral inner capsid
C	0044423	cellular_component	virion component
d	0000166	molecular_function	nucleotide binding
d	0003724	molecular_function	RNA helicase activity
d	0004386	molecular_function	helicase activity
d	0005524	molecular_function	ATP binding
d	0006370	biological_process	7-methylguanosine mRNA capping
d	0006397	biological_process	mRNA processing
d	0008270	molecular_function	zinc ion binding
d	0016787	molecular_function	hydrolase activity
d	0016887	molecular_function	ATP hydrolysis activity
d	0019028	cellular_component	viral capsid
d	0039616	cellular_component	T=2 icosahedral viral capsid
d	0039625	cellular_component	viral inner capsid
d	0044423	cellular_component	virion component
d	0046872	molecular_function	metal ion binding
D	0019028	cellular_component	viral capsid
D	0020002	cellular_component	host cell plasma membrane
D	0033650	cellular_component	host cell mitochondrion
D	0039624	cellular_component	viral outer capsid
D	0044165	cellular_component	host cell endoplasmic reticulum
D	0044423	cellular_component	virion component
D	0046718	biological_process	symbiont entry into host cell
D	0046812	molecular_function	host cell surface binding
D	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
e	0000166	molecular_function	nucleotide binding
e	0003724	molecular_function	RNA helicase activity
e	0004386	molecular_function	helicase activity
e	0005524	molecular_function	ATP binding
e	0006370	biological_process	7-methylguanosine mRNA capping
e	0006397	biological_process	mRNA processing
e	0008270	molecular_function	zinc ion binding
e	0016787	molecular_function	hydrolase activity
e	0016887	molecular_function	ATP hydrolysis activity
e	0019028	cellular_component	viral capsid
e	0039616	cellular_component	T=2 icosahedral viral capsid
e	0039625	cellular_component	viral inner capsid
e	0044423	cellular_component	virion component
e	0046872	molecular_function	metal ion binding
E	0019028	cellular_component	viral capsid
E	0020002	cellular_component	host cell plasma membrane
E	0033650	cellular_component	host cell mitochondrion
E	0039624	cellular_component	viral outer capsid
E	0044165	cellular_component	host cell endoplasmic reticulum
E	0044423	cellular_component	virion component
E	0046718	biological_process	symbiont entry into host cell
E	0046812	molecular_function	host cell surface binding
E	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
f	0000166	molecular_function	nucleotide binding
f	0003724	molecular_function	RNA helicase activity
f	0004386	molecular_function	helicase activity
f	0005524	molecular_function	ATP binding
f	0006370	biological_process	7-methylguanosine mRNA capping
f	0006397	biological_process	mRNA processing
f	0008270	molecular_function	zinc ion binding
f	0016787	molecular_function	hydrolase activity
f	0016887	molecular_function	ATP hydrolysis activity
f	0019028	cellular_component	viral capsid
f	0039616	cellular_component	T=2 icosahedral viral capsid
f	0039625	cellular_component	viral inner capsid
f	0044423	cellular_component	virion component
f	0046872	molecular_function	metal ion binding
F	0019028	cellular_component	viral capsid
F	0020002	cellular_component	host cell plasma membrane
F	0033650	cellular_component	host cell mitochondrion
F	0039624	cellular_component	viral outer capsid
F	0044165	cellular_component	host cell endoplasmic reticulum
F	0044423	cellular_component	virion component
F	0046718	biological_process	symbiont entry into host cell
F	0046812	molecular_function	host cell surface binding
F	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
g	0000166	molecular_function	nucleotide binding
g	0003724	molecular_function	RNA helicase activity
g	0004386	molecular_function	helicase activity
g	0005524	molecular_function	ATP binding
g	0006370	biological_process	7-methylguanosine mRNA capping
g	0006397	biological_process	mRNA processing
g	0008270	molecular_function	zinc ion binding
g	0016787	molecular_function	hydrolase activity
g	0016887	molecular_function	ATP hydrolysis activity
g	0019028	cellular_component	viral capsid
g	0039616	cellular_component	T=2 icosahedral viral capsid
g	0039625	cellular_component	viral inner capsid
g	0044423	cellular_component	virion component
g	0046872	molecular_function	metal ion binding
G	0003723	molecular_function	RNA binding
G	0005198	molecular_function	structural molecule activity
G	0006351	biological_process	DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0019028	cellular_component	viral capsid
G	0019058	biological_process	viral life cycle
G	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
G	0030430	cellular_component	host cell cytoplasm
G	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
G	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
G	0039624	cellular_component	viral outer capsid
G	0042025	cellular_component	host cell nucleus
G	0044423	cellular_component	virion component
G	0046872	molecular_function	metal ion binding
G	0052031	biological_process	symbiont-mediated perturbation of host defense response
G	0052170	biological_process	symbiont-mediated suppression of host innate immune response
h	0000166	molecular_function	nucleotide binding
h	0003724	molecular_function	RNA helicase activity
h	0004386	molecular_function	helicase activity
h	0005524	molecular_function	ATP binding
h	0006370	biological_process	7-methylguanosine mRNA capping
h	0006397	biological_process	mRNA processing
h	0008270	molecular_function	zinc ion binding
h	0016787	molecular_function	hydrolase activity
h	0016887	molecular_function	ATP hydrolysis activity
h	0019028	cellular_component	viral capsid
h	0039616	cellular_component	T=2 icosahedral viral capsid
h	0039625	cellular_component	viral inner capsid
h	0044423	cellular_component	virion component
h	0046872	molecular_function	metal ion binding
H	0019028	cellular_component	viral capsid
H	0020002	cellular_component	host cell plasma membrane
H	0033650	cellular_component	host cell mitochondrion
H	0039624	cellular_component	viral outer capsid
H	0044165	cellular_component	host cell endoplasmic reticulum
H	0044423	cellular_component	virion component
H	0046718	biological_process	symbiont entry into host cell
H	0046812	molecular_function	host cell surface binding
H	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
i	0000166	molecular_function	nucleotide binding
i	0003724	molecular_function	RNA helicase activity
i	0004386	molecular_function	helicase activity
i	0005524	molecular_function	ATP binding
i	0006370	biological_process	7-methylguanosine mRNA capping
i	0006397	biological_process	mRNA processing
i	0008270	molecular_function	zinc ion binding
i	0016787	molecular_function	hydrolase activity
i	0016887	molecular_function	ATP hydrolysis activity
i	0019028	cellular_component	viral capsid
i	0039616	cellular_component	T=2 icosahedral viral capsid
i	0039625	cellular_component	viral inner capsid
i	0044423	cellular_component	virion component
i	0046872	molecular_function	metal ion binding
I	0003723	molecular_function	RNA binding
I	0005198	molecular_function	structural molecule activity
I	0006351	biological_process	DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0019028	cellular_component	viral capsid
I	0019058	biological_process	viral life cycle
I	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
I	0030430	cellular_component	host cell cytoplasm
I	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
I	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
I	0039624	cellular_component	viral outer capsid
I	0042025	cellular_component	host cell nucleus
I	0044423	cellular_component	virion component
I	0046872	molecular_function	metal ion binding
I	0052031	biological_process	symbiont-mediated perturbation of host defense response
I	0052170	biological_process	symbiont-mediated suppression of host innate immune response
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
J	0004484	molecular_function	mRNA guanylyltransferase activity
J	0005524	molecular_function	ATP binding
J	0005525	molecular_function	GTP binding
J	0006370	biological_process	7-methylguanosine mRNA capping
J	0006397	biological_process	mRNA processing
J	0008168	molecular_function	methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0019028	cellular_component	viral capsid
J	0019030	cellular_component	icosahedral viral capsid
J	0032259	biological_process	methylation
J	0039624	cellular_component	viral outer capsid
J	0044423	cellular_component	virion component
J	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
k	0000166	molecular_function	nucleotide binding
k	0003724	molecular_function	RNA helicase activity
k	0004386	molecular_function	helicase activity
k	0005524	molecular_function	ATP binding
k	0006370	biological_process	7-methylguanosine mRNA capping
k	0006397	biological_process	mRNA processing
k	0008270	molecular_function	zinc ion binding
k	0016787	molecular_function	hydrolase activity
k	0016887	molecular_function	ATP hydrolysis activity
k	0019028	cellular_component	viral capsid
k	0039616	cellular_component	T=2 icosahedral viral capsid
k	0039625	cellular_component	viral inner capsid
k	0044423	cellular_component	virion component
k	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0003724	molecular_function	RNA helicase activity
K	0004386	molecular_function	helicase activity
K	0005524	molecular_function	ATP binding
K	0006370	biological_process	7-methylguanosine mRNA capping
K	0006397	biological_process	mRNA processing
K	0008270	molecular_function	zinc ion binding
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0019028	cellular_component	viral capsid
K	0039616	cellular_component	T=2 icosahedral viral capsid
K	0039625	cellular_component	viral inner capsid
K	0044423	cellular_component	virion component
K	0046872	molecular_function	metal ion binding
L	0003723	molecular_function	RNA binding
L	0005198	molecular_function	structural molecule activity
L	0006351	biological_process	DNA-templated transcription
L	0008270	molecular_function	zinc ion binding
L	0019028	cellular_component	viral capsid
L	0019058	biological_process	viral life cycle
L	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
L	0030430	cellular_component	host cell cytoplasm
L	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
L	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
L	0039624	cellular_component	viral outer capsid
L	0042025	cellular_component	host cell nucleus
L	0044423	cellular_component	virion component
L	0046872	molecular_function	metal ion binding
L	0052031	biological_process	symbiont-mediated perturbation of host defense response
L	0052170	biological_process	symbiont-mediated suppression of host innate immune response
m	0000166	molecular_function	nucleotide binding
m	0003724	molecular_function	RNA helicase activity
m	0004386	molecular_function	helicase activity
m	0005524	molecular_function	ATP binding
m	0006370	biological_process	7-methylguanosine mRNA capping
m	0006397	biological_process	mRNA processing
m	0008270	molecular_function	zinc ion binding
m	0016787	molecular_function	hydrolase activity
m	0016887	molecular_function	ATP hydrolysis activity
m	0019028	cellular_component	viral capsid
m	0039616	cellular_component	T=2 icosahedral viral capsid
m	0039625	cellular_component	viral inner capsid
m	0044423	cellular_component	virion component
m	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0003724	molecular_function	RNA helicase activity
M	0004386	molecular_function	helicase activity
M	0005524	molecular_function	ATP binding
M	0006370	biological_process	7-methylguanosine mRNA capping
M	0006397	biological_process	mRNA processing
M	0008270	molecular_function	zinc ion binding
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0019028	cellular_component	viral capsid
M	0039616	cellular_component	T=2 icosahedral viral capsid
M	0039625	cellular_component	viral inner capsid
M	0044423	cellular_component	virion component
M	0046872	molecular_function	metal ion binding
V	0005198	molecular_function	structural molecule activity
V	0019028	cellular_component	viral capsid
V	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
V	0039560	biological_process	symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity
V	0044163	cellular_component	host cytoskeleton
V	0044423	cellular_component	virion component
V	0052031	biological_process	symbiont-mediated perturbation of host defense response
V	0052170	biological_process	symbiont-mediated suppression of host innate immune response
W	0000166	molecular_function	nucleotide binding
W	0001172	biological_process	RNA-templated transcription
W	0003723	molecular_function	RNA binding
W	0003968	molecular_function	RNA-directed RNA polymerase activity
W	0016740	molecular_function	transferase activity
W	0016779	molecular_function	nucleotidyltransferase activity
W	0016787	molecular_function	hydrolase activity
W	0019013	cellular_component	viral nucleocapsid
W	0019028	cellular_component	viral capsid
W	0019079	biological_process	viral genome replication
W	0032774	biological_process	RNA biosynthetic process
W	0034062	molecular_function	5'-3' RNA polymerase activity
W	0044423	cellular_component	virion component
W	0046872	molecular_function	metal ion binding
Y	0000166	molecular_function	nucleotide binding
Y	0003724	molecular_function	RNA helicase activity
Y	0004386	molecular_function	helicase activity
Y	0005524	molecular_function	ATP binding
Y	0006370	biological_process	7-methylguanosine mRNA capping
Y	0006397	biological_process	mRNA processing
Y	0008270	molecular_function	zinc ion binding
Y	0016787	molecular_function	hydrolase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0019028	cellular_component	viral capsid
Y	0039616	cellular_component	T=2 icosahedral viral capsid
Y	0039625	cellular_component	viral inner capsid
Y	0044423	cellular_component	virion component
Y	0046872	molecular_function	metal ion binding
Z	0000166	molecular_function	nucleotide binding
Z	0003724	molecular_function	RNA helicase activity
Z	0004386	molecular_function	helicase activity
Z	0005524	molecular_function	ATP binding
Z	0006370	biological_process	7-methylguanosine mRNA capping
Z	0006397	biological_process	mRNA processing
Z	0008270	molecular_function	zinc ion binding
Z	0016787	molecular_function	hydrolase activity
Z	0016887	molecular_function	ATP hydrolysis activity
Z	0019028	cellular_component	viral capsid
Z	0039616	cellular_component	T=2 icosahedral viral capsid
Z	0039625	cellular_component	viral inner capsid
Z	0044423	cellular_component	virion component
Z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cmh..ClgvVgslqrklkHlph..H

Chain	Residue	Details
G	CYS51-HIS71
i	CYS183-HIS203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Lipidation: {"description":"N-myristoyl glycine; by host","evidences":[{"source":"PubMed","id":"1548757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	66
Details	Zinc finger: {"description":"CCHC-type","evidences":[{"source":"PubMed","id":"11230122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P07939","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	257
Details	Region: {"description":"Probable N7-modifying activity","evidences":[{"source":"PubMed","id":"10801118","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	218
Details	Region: {"description":"Probable O-methyltransferase activity","evidences":[{"source":"PubMed","id":"10801118","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Contributes to the autoguanylylation","evidences":[{"source":"PubMed","id":"10644745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Involved in formation of the phosphoamide bond (autoguanylation)","evidences":[{"source":"PubMed","id":"10644745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	55
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	210
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	155
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	110
Details	Zinc finger: {"description":"C2H2-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	237
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12464184","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N38","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12464184","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N38","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---