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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CXD

Native human GABAA receptor of beta2-alpha1-beta1-beta1-gamma2 assembly

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007268biological_processchemical synaptic transmission
A0016020cellular_componentmembrane
A0016917molecular_functionGABA receptor activity
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032229biological_processnegative regulation of synaptic transmission, GABAergic
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0043197cellular_componentdendritic spine
A0045211cellular_componentpostsynaptic membrane
A0048666biological_processneuron development
A0051932biological_processsynaptic transmission, GABAergic
A0060078biological_processregulation of postsynaptic membrane potential
A0060119biological_processinner ear receptor cell development
A0060384biological_processinnervation
A0070062cellular_componentextracellular exosome
A0071420biological_processcellular response to histamine
A0090102biological_processcochlea development
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A0160001biological_processextrasynaptic signaling via GABA
A1902476biological_processchloride transmembrane transport
A1902711cellular_componentGABA-A receptor complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904862biological_processinhibitory synapse assembly
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0008503molecular_functionbenzodiazepine receptor activity
B0016020cellular_componentmembrane
B0016917molecular_functionGABA receptor activity
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032590cellular_componentdendrite membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0038023molecular_functionsignaling receptor activity
B0043197cellular_componentdendritic spine
B0045211cellular_componentpostsynaptic membrane
B0051932biological_processsynaptic transmission, GABAergic
B0060078biological_processregulation of postsynaptic membrane potential
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B0160001biological_processextrasynaptic signaling via GABA
B1902476biological_processchloride transmembrane transport
B1902710cellular_componentGABA receptor complex
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005253molecular_functionmonoatomic anion channel activity
C0005254molecular_functionchloride channel activity
C0005635cellular_componentnuclear envelope
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007165biological_processsignal transduction
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0009636biological_processresponse to toxic substance
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0021954biological_processcentral nervous system neuron development
C0022851molecular_functionGABA-gated chloride ion channel activity
C0030425cellular_componentdendrite
C0030594molecular_functionneurotransmitter receptor activity
C0032229biological_processnegative regulation of synaptic transmission, GABAergic
C0032570biological_processresponse to progesterone
C0034220biological_processmonoatomic ion transmembrane transport
C0034707cellular_componentchloride channel complex
C0042391biological_processregulation of membrane potential
C0042698biological_processovulation cycle
C0043235cellular_componentreceptor complex
C0045211cellular_componentpostsynaptic membrane
C0048787cellular_componentpresynaptic active zone membrane
C0050811molecular_functionGABA receptor binding
C0051932biological_processsynaptic transmission, GABAergic
C0060078biological_processregulation of postsynaptic membrane potential
C0071420biological_processcellular response to histamine
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098982cellular_componentGABA-ergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0099634cellular_componentpostsynaptic specialization membrane
C0150047molecular_functionG protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
C0160001biological_processextrasynaptic signaling via GABA
C1902476biological_processchloride transmembrane transport
C1902711cellular_componentGABA-A receptor complex
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005253molecular_functionmonoatomic anion channel activity
D0005254molecular_functionchloride channel activity
D0005635cellular_componentnuclear envelope
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007165biological_processsignal transduction
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0009636biological_processresponse to toxic substance
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0021954biological_processcentral nervous system neuron development
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030425cellular_componentdendrite
D0030594molecular_functionneurotransmitter receptor activity
D0032229biological_processnegative regulation of synaptic transmission, GABAergic
D0032570biological_processresponse to progesterone
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0042391biological_processregulation of membrane potential
D0042698biological_processovulation cycle
D0043235cellular_componentreceptor complex
D0045211cellular_componentpostsynaptic membrane
D0048787cellular_componentpresynaptic active zone membrane
D0050811molecular_functionGABA receptor binding
D0051932biological_processsynaptic transmission, GABAergic
D0060078biological_processregulation of postsynaptic membrane potential
D0071420biological_processcellular response to histamine
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098982cellular_componentGABA-ergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D0099634cellular_componentpostsynaptic specialization membrane
D0150047molecular_functionG protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
D0160001biological_processextrasynaptic signaling via GABA
D1902476biological_processchloride transmembrane transport
D1902711cellular_componentGABA-A receptor complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0008503molecular_functionbenzodiazepine receptor activity
E0016020cellular_componentmembrane
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032229biological_processnegative regulation of synaptic transmission, GABAergic
E0032590cellular_componentdendrite membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0045211cellular_componentpostsynaptic membrane
E0051932biological_processsynaptic transmission, GABAergic
E0060078biological_processregulation of postsynaptic membrane potential
E0071420biological_processcellular response to histamine
E0098794cellular_componentpostsynapse
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E0160001biological_processextrasynaptic signaling via GABA
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCNVRH
ChainResidueDetails
JPHE430-HIS436
ITYR191-HIS197
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
CCYS136-CYS150
BCYS139-CYS153
ECYS151-CYS165
ACYS136-CYS150
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues79
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues37
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues9
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"P28472","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues7
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues81
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30266951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues151
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"UniProtKB","id":"P15431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues83
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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