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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CXC

Native human GABAA receptor of beta3-alpha1-gamma2-beta2-alpha2 assembly

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007165biological_processsignal transduction
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007268biological_processchemical synaptic transmission
A0007399biological_processnervous system development
A0007420biological_processbrain development
A0007612biological_processlearning
A0007613biological_processmemory
A0009410biological_processresponse to xenobiotic stimulus
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0019098biological_processreproductive behavior
A0021549biological_processcerebellum development
A0022851molecular_functionGABA-gated chloride ion channel activity
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0035176biological_processsocial behavior
A0035640biological_processexploration behavior
A0042747biological_processcircadian sleep/wake cycle, REM sleep
A0042802molecular_functionidentical protein binding
A0043197cellular_componentdendritic spine
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048666biological_processneuron development
A0051932biological_processsynaptic transmission, GABAergic
A0060021biological_processroof of mouth development
A0060022biological_processhard palate development
A0060080biological_processinhibitory postsynaptic potential
A0060119biological_processinner ear receptor cell development
A0060384biological_processinnervation
A0061744biological_processmotor behavior
A0071294biological_processcellular response to zinc ion
A0071420biological_processcellular response to histamine
A0072347biological_processresponse to anesthetic
A0090102biological_processcochlea development
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1902476biological_processchloride transmembrane transport
A1902711cellular_componentGABA-A receptor complex
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1904862biological_processinhibitory synapse assembly
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0008503molecular_functionbenzodiazepine receptor activity
B0016020cellular_componentmembrane
B0016917molecular_functionGABA receptor activity
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032590cellular_componentdendrite membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0038023molecular_functionsignaling receptor activity
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051932biological_processsynaptic transmission, GABAergic
B0060078biological_processregulation of postsynaptic membrane potential
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1902476biological_processchloride transmembrane transport
B1902710cellular_componentGABA receptor complex
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005254molecular_functionchloride channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0007214biological_processgamma-aminobutyric acid signaling pathway
C0007268biological_processchemical synaptic transmission
C0008503molecular_functionbenzodiazepine receptor activity
C0009791biological_processpost-embryonic development
C0016020cellular_componentmembrane
C0022851molecular_functionGABA-gated chloride ion channel activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030534biological_processadult behavior
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0032590cellular_componentdendrite membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034707cellular_componentchloride channel complex
C0042995cellular_componentcell projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0051932biological_processsynaptic transmission, GABAergic
C0060078biological_processregulation of postsynaptic membrane potential
C0071420biological_processcellular response to histamine
C0098794cellular_componentpostsynapse
C0098982cellular_componentGABA-ergic synapse
C0099634cellular_componentpostsynaptic specialization membrane
C1902476biological_processchloride transmembrane transport
C1902711cellular_componentGABA-A receptor complex
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1904862biological_processinhibitory synapse assembly
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0008503molecular_functionbenzodiazepine receptor activity
E0016020cellular_componentmembrane
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030659cellular_componentcytoplasmic vesicle membrane
E0030672cellular_componentsynaptic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032590cellular_componentdendrite membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0038023molecular_functionsignaling receptor activity
E0042995cellular_componentcell projection
E0043025cellular_componentneuronal cell body
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051932biological_processsynaptic transmission, GABAergic
E0060077cellular_componentinhibitory synapse
E0060078biological_processregulation of postsynaptic membrane potential
E0098794cellular_componentpostsynapse
E0098982cellular_componentGABA-ergic synapse
E0099505biological_processregulation of presynaptic membrane potential
E0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E0099634cellular_componentpostsynaptic specialization membrane
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
DCYS136-CYS150
BCYS139-CYS153
ACYS136-CYS150
CCYS151-CYS165
ECYS138-CYS152
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCNVRH
ChainResidueDetails
KPHE430-HIS436
LTYR191-HIS197
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues85
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues11
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues81
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues22
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues36
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30266951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues5
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues158
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"P28472","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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