Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CT0

Native human GABAA receptor of beta2-alpha1-beta2-alpha2-gamma2 assembly

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0008503molecular_functionbenzodiazepine receptor activity
B0016020cellular_componentmembrane
B0016917molecular_functionGABA receptor activity
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032590cellular_componentdendrite membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0038023molecular_functionsignaling receptor activity
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051932biological_processsynaptic transmission, GABAergic
B0060078biological_processregulation of postsynaptic membrane potential
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1902476biological_processchloride transmembrane transport
B1902710cellular_componentGABA receptor complex
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0008503molecular_functionbenzodiazepine receptor activity
D0016020cellular_componentmembrane
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030659cellular_componentcytoplasmic vesicle membrane
D0030672cellular_componentsynaptic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032590cellular_componentdendrite membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0038023molecular_functionsignaling receptor activity
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051932biological_processsynaptic transmission, GABAergic
D0060077cellular_componentinhibitory synapse
D0060078biological_processregulation of postsynaptic membrane potential
D0098794cellular_componentpostsynapse
D0098982cellular_componentGABA-ergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D0099634cellular_componentpostsynaptic specialization membrane
D1902476biological_processchloride transmembrane transport
D1902711cellular_componentGABA-A receptor complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1904862biological_processinhibitory synapse assembly
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0007268biological_processchemical synaptic transmission
E0008503molecular_functionbenzodiazepine receptor activity
E0009791biological_processpost-embryonic development
E0016020cellular_componentmembrane
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030534biological_processadult behavior
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032590cellular_componentdendrite membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0042995cellular_componentcell projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051932biological_processsynaptic transmission, GABAergic
E0060078biological_processregulation of postsynaptic membrane potential
E0071420biological_processcellular response to histamine
E0098794cellular_componentpostsynapse
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC
ChainResidueDetails
ACYS136-CYS150
DCYS138-CYS152
ECYS151-CYS165
BCYS139-CYS153
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
ITYR191-HIS197
JPHE430-HIS436
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues237
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues31
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues53
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"P28472","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15431","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues81
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30266951","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D6U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P14867","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29950725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon