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9CSK

Crystal structure of CDK4 cyclin D1 in complex with atirmociclib

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
B0000082biological_processG1/S transition of mitotic cell cycle
B0000166molecular_functionnucleotide binding
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000785cellular_componentchromatin
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005923cellular_componentbicellular tight junction
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0010468biological_processregulation of gene expression
B0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0016740molecular_functiontransferase activity
B0030332molecular_functioncyclin binding
B0031965cellular_componentnuclear membrane
B0048146biological_processpositive regulation of fibroblast proliferation
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060260biological_processregulation of transcription initiation by RNA polymerase II
B0061469biological_processregulation of type B pancreatic cell proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071353biological_processcellular response to interleukin-4
B0097128cellular_componentcyclin D1-CDK4 complex
B0097129cellular_componentcyclin D2-CDK4 complex
B0097130cellular_componentcyclin D3-CDK4 complex
B0106310molecular_functionprotein serine kinase activity
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B1904637biological_processcellular response to ionomycin
D0000082biological_processG1/S transition of mitotic cell cycle
D0000166molecular_functionnucleotide binding
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0000785cellular_componentchromatin
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005667cellular_componenttranscription regulator complex
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005923cellular_componentbicellular tight junction
D0007165biological_processsignal transduction
D0008284biological_processpositive regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0010389biological_processregulation of G2/M transition of mitotic cell cycle
D0010468biological_processregulation of gene expression
D0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
D0016740molecular_functiontransferase activity
D0030332molecular_functioncyclin binding
D0031965cellular_componentnuclear membrane
D0048146biological_processpositive regulation of fibroblast proliferation
D0051301biological_processcell division
D0051726biological_processregulation of cell cycle
D0060260biological_processregulation of transcription initiation by RNA polymerase II
D0061469biological_processregulation of type B pancreatic cell proliferation
D0071222biological_processcellular response to lipopolysaccharide
D0071353biological_processcellular response to interleukin-4
D0097128cellular_componentcyclin D1-CDK4 complex
D0097129cellular_componentcyclin D2-CDK4 complex
D0097130cellular_componentcyclin D3-CDK4 complex
D0106310molecular_functionprotein serine kinase activity
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D1904637biological_processcellular response to ionomycin
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK
ChainResidueDetails
BILE12-LYS35

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV
ChainResidueDetails
BILE136-VAL148

site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RkiVatWMlevceeqkCeeevFplAMnYLDRF
ChainResidueDetails
AARG57-PHE88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
BPRO143
DPRO143
CLYS269

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BILE12
BLYS35
DILE12
DLYS35

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BALA2
DALA2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:19237555, ECO:0000269|PubMed:19237565, ECO:0000269|PubMed:19487459, ECO:0007744|PubMed:19369195
ChainResidueDetails
BVAL175
DVAL175

237423

PDB entries from 2025-06-11

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