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9CRS

Native human GABAA receptor of beta2-alpha1-beta2-alpha1-gamma2 assembly

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007214biological_processgamma-aminobutyric acid signaling pathway
B0008503molecular_functionbenzodiazepine receptor activity
B0016020cellular_componentmembrane
B0016917molecular_functionGABA receptor activity
B0022851molecular_functionGABA-gated chloride ion channel activity
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032590cellular_componentdendrite membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0038023molecular_functionsignaling receptor activity
B0043197cellular_componentdendritic spine
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051932biological_processsynaptic transmission, GABAergic
B0060078biological_processregulation of postsynaptic membrane potential
B0098794cellular_componentpostsynapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1902476biological_processchloride transmembrane transport
B1902710cellular_componentGABA receptor complex
B1902711cellular_componentGABA-A receptor complex
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1904862biological_processinhibitory synapse assembly
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0007214biological_processgamma-aminobutyric acid signaling pathway
D0008503molecular_functionbenzodiazepine receptor activity
D0016020cellular_componentmembrane
D0016917molecular_functionGABA receptor activity
D0022851molecular_functionGABA-gated chloride ion channel activity
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032590cellular_componentdendrite membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0038023molecular_functionsignaling receptor activity
D0043197cellular_componentdendritic spine
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051932biological_processsynaptic transmission, GABAergic
D0060078biological_processregulation of postsynaptic membrane potential
D0098794cellular_componentpostsynapse
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1902476biological_processchloride transmembrane transport
D1902710cellular_componentGABA receptor complex
D1902711cellular_componentGABA-A receptor complex
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1904862biological_processinhibitory synapse assembly
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0007268biological_processchemical synaptic transmission
E0008503molecular_functionbenzodiazepine receptor activity
E0009791biological_processpost-embryonic development
E0016020cellular_componentmembrane
E0022851molecular_functionGABA-gated chloride ion channel activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030534biological_processadult behavior
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032590cellular_componentdendrite membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034707cellular_componentchloride channel complex
E0042995cellular_componentcell projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051932biological_processsynaptic transmission, GABAergic
E0060078biological_processregulation of postsynaptic membrane potential
E0071420biological_processcellular response to histamine
E0098794cellular_componentpostsynapse
E0098982cellular_componentGABA-ergic synapse
E0099634cellular_componentpostsynaptic specialization membrane
E1902476biological_processchloride transmembrane transport
E1902711cellular_componentGABA-A receptor complex
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E1904862biological_processinhibitory synapse assembly
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMhLedFPmDahaC
ChainResidueDetails
BCYS139-CYS153
ECYS151-CYS165
ACYS136-CYS150

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
ITYR191-HIS197
JPHE430-HIS436

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues248
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
EGLN1-PHE236
EARG284-ALA295
ELEU434-LEU436
DGLN1-PHE226
DASN275-THR284
DTYR415-GLN429

site_idSWS_FT_FI2
Number of Residues83
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53
ChainResidueDetails
ETHR237-ILE257
EALA264-ALA283
EMET296-PHE320
ETYR413-TYR433
DVAL227-LEU247
DPRO253-ARG274
DALA285-THR306
DLEU395-THR414

site_idSWS_FT_FI3
Number of Residues96
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
EASN258-PRO263
EVAL321-SER412
DASN248-VAL252
DVAL307-ARG394

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN13
EASN90
ATHR202
CTYR97
CSER156
CTHR202

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53
ChainResidueDetails
EASN208
DTHR130

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30266951
ChainResidueDetails
BTRP246
DTRP246

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN11
DASN11

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U, ECO:0007744|PDB:6I53
ChainResidueDetails
BASN111
DASN111
CASN80
CASN149

237735

PDB entries from 2025-06-18

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