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9COO

Nanobody 4 bound to Apolipoprotein B 100

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005319molecular_functionlipid transporter activity
A0006869biological_processlipid transport
B0005515molecular_functionprotein binding
B0005618cellular_componentcell wall
B0006974biological_processDNA damage response
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0019865molecular_functionimmunoglobulin binding
B0030288cellular_componentouter membrane-bounded periplasmic space
B0034219biological_processcarbohydrate transmembrane transport
B0034289biological_processdetection of maltose stimulus
B0042597cellular_componentperiplasmic space
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0060326biological_processcell chemotaxis
B1901982molecular_functionmaltose binding
R0001523biological_processretinoid metabolic process
R0001540molecular_functionamyloid-beta binding
R0001618molecular_functionvirus receptor activity
R0001920biological_processnegative regulation of receptor recycling
R0002020molecular_functionprotease binding
R0005041molecular_functionlow-density lipoprotein particle receptor activity
R0005509molecular_functioncalcium ion binding
R0005515molecular_functionprotein binding
R0005764cellular_componentlysosome
R0005768cellular_componentendosome
R0005769cellular_componentearly endosome
R0005770cellular_componentlate endosome
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0005905cellular_componentclathrin-coated pit
R0006629biological_processlipid metabolic process
R0006869biological_processlipid transport
R0006897biological_processendocytosis
R0006898biological_processreceptor-mediated endocytosis
R0006909biological_processphagocytosis
R0007616biological_processlong-term memory
R0008202biological_processsteroid metabolic process
R0008203biological_processcholesterol metabolic process
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0010008cellular_componentendosome membrane
R0010605biological_processnegative regulation of macromolecule metabolic process
R0010628biological_processpositive regulation of gene expression
R0010629biological_processnegative regulation of gene expression
R0010867biological_processpositive regulation of triglyceride biosynthetic process
R0010899biological_processregulation of phosphatidylcholine catabolic process
R0010989biological_processnegative regulation of low-density lipoprotein particle clearance
R0015914biological_processphospholipid transport
R0016020cellular_componentmembrane
R0016323cellular_componentbasolateral plasma membrane
R0030169molecular_functionlow-density lipoprotein particle binding
R0030229molecular_functionvery-low-density lipoprotein particle receptor activity
R0030299biological_processintestinal cholesterol absorption
R0030301biological_processcholesterol transport
R0030669cellular_componentclathrin-coated endocytic vesicle membrane
R0032050molecular_functionclathrin heavy chain binding
R0034362cellular_componentlow-density lipoprotein particle
R0034381biological_processplasma lipoprotein particle clearance
R0034383biological_processlow-density lipoprotein particle clearance
R0034384biological_processhigh-density lipoprotein particle clearance
R0036020cellular_componentendolysosome membrane
R0036477cellular_componentsomatodendritic compartment
R0042632biological_processcholesterol homeostasis
R0042802molecular_functionidentical protein binding
R0043235cellular_componentreceptor complex
R0045177cellular_componentapical part of cell
R0046718biological_processsymbiont entry into host cell
R0048844biological_processartery morphogenesis
R0050729biological_processpositive regulation of inflammatory response
R0051241biological_processnegative regulation of multicellular organismal process
R0051246biological_processregulation of protein metabolic process
R0051248biological_processnegative regulation of protein metabolic process
R0051649biological_processestablishment of localization in cell
R0060090molecular_functionmolecular adaptor activity
R0061771biological_processresponse to caloric restriction
R0061889biological_processnegative regulation of astrocyte activation
R0070508biological_processcholesterol import
R0071398biological_processcellular response to fatty acid
R0071404biological_processcellular response to low-density lipoprotein particle stimulus
R0071813molecular_functionlipoprotein particle binding
R0090118biological_processreceptor-mediated endocytosis involved in cholesterol transport
R0090181biological_processregulation of cholesterol metabolic process
R0097242biological_processamyloid-beta clearance
R0097443cellular_componentsorting endosome
R0150094biological_processamyloid-beta clearance by cellular catabolic process
R1903979biological_processnegative regulation of microglial cell activation
R1905167biological_processpositive regulation of lysosomal protein catabolic process
R1905907biological_processnegative regulation of amyloid fibril formation
R1990666cellular_componentPCSK9-LDLR complex
Functional Information from PROSITE/UniProt
site_idPS00010
Number of Residues12
DetailsASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CnDlkigYeClC
ChainResidueDetails
RCYS329-CYS340
RCYS368-CYS379

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR197-HIS203
HTYR204-HIS210

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
BPRO108-ASN125

site_idPS01186
Number of Residues15
DetailsEGF_2 EGF-like domain signature 2. ClCpdGFqlvaqrr.C
ChainResidueDetails
RCYS338-CYS352
RCYS377-CYS392

site_idPS01187
Number of Residues24
DetailsEGF_CA Calcium-binding EGF-like domain signature. DiDECqdpdt.........Csql....CvNleggYkC
ChainResidueDetails
RASP354-CYS377

site_idPS01209
Number of Residues23
DetailsLDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpqfwr.CDgqvDCdng.SDEqg...C
ChainResidueDetails
RCYS82-CYS104
RCYS121-CYS143
RCYS160-CYS184
RCYS209-CYS231
RCYS248-CYS270
RCYS289-CYS313

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsRegion: {"description":"LDL receptor binding"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsRegion: {"description":"Basic (possible receptor binding region)"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues40
DetailsDomain: {"description":"LDL-receptor class A 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19520913","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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