9CLS
Cryo-EM model derived from localized reconstruction of human adenovirus 6 (Ad6)-hexon-FII complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| J | 0005198 | molecular_function | structural molecule activity |
| J | 0019028 | cellular_component | viral capsid |
| J | 0039623 | cellular_component | T=25 icosahedral viral capsid |
| J | 0042025 | cellular_component | host cell nucleus |
| J | 0043657 | cellular_component | host cell |
| J | 0044423 | cellular_component | virion component |
| J | 0046718 | biological_process | symbiont entry into host cell |
| J | 0075521 | biological_process | microtubule-dependent intracellular transport of viral material towards nucleus |
| J | 0075606 | biological_process | transport of viral material towards nucleus |
| K | 0005198 | molecular_function | structural molecule activity |
| K | 0019028 | cellular_component | viral capsid |
| K | 0039623 | cellular_component | T=25 icosahedral viral capsid |
| K | 0042025 | cellular_component | host cell nucleus |
| K | 0043657 | cellular_component | host cell |
| K | 0044423 | cellular_component | virion component |
| K | 0046718 | biological_process | symbiont entry into host cell |
| K | 0075521 | biological_process | microtubule-dependent intracellular transport of viral material towards nucleus |
| K | 0075606 | biological_process | transport of viral material towards nucleus |
| L | 0005198 | molecular_function | structural molecule activity |
| L | 0019028 | cellular_component | viral capsid |
| L | 0039623 | cellular_component | T=25 icosahedral viral capsid |
| L | 0042025 | cellular_component | host cell nucleus |
| L | 0043657 | cellular_component | host cell |
| L | 0044423 | cellular_component | virion component |
| L | 0046718 | biological_process | symbiont entry into host cell |
| L | 0075521 | biological_process | microtubule-dependent intracellular transport of viral material towards nucleus |
| L | 0075606 | biological_process | transport of viral material towards nucleus |
| Z | 0004252 | molecular_function | serine-type endopeptidase activity |
| Z | 0005509 | molecular_function | calcium ion binding |
| Z | 0005576 | cellular_component | extracellular region |
| Z | 0006508 | biological_process | proteolysis |
| Z | 0007596 | biological_process | blood coagulation |
Functional Information from PROSITE/UniProt
| site_id | PS00011 |
| Number of Residues | 26 |
| Details | GLA_1 Vitamin K-dependent carboxylation domain. EcvEEtCsyeeafEalesstatdv.FW |
| Chain | Residue | Details |
| Z | CGU16-TRP41 |
| site_id | PS00021 |
| Number of Residues | 14 |
| Details | KRINGLE_1 Kringle domain signature. FCRNpdssttgpWC |
| Chain | Residue | Details |
| Z | PHE113-CYS126 | |
| Z | PHE218-CYS231 |
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| Z | LEU359-CYS364 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| Z | ASP519-VAL530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI6 |
| Number of Residues | 128 |
| Details | Peptide: {"description":"Activation peptide fragment 2","featureId":"PRO_0000028162"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 78 |
| Details | Domain: {"description":"Kringle 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 78 |
| Details | Domain: {"description":"Kringle 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by thrombin"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by factor Xa","evidences":[{"source":"PubMed","id":"34265300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3759958","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6305407","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"6305407","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
