Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9CKV

Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCneGrvGRhC

Chain	Residue	Details
B	CYS469-CYS480
B	CYS559-CYS570

site_id	PS00243
Number of Residues	14
Details	I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsNn..GeCvCgqCvC

Chain	Residue	Details
B	CYS505-CYS518
B	CYS548-CYS561
B	CYS587-CYS600

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Repeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	53
Details	Repeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	52
Details	Repeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	65
Details	Repeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	59
Details	Repeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	238
Details	Domain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	6
Details	Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"23125415","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	19
Details	Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"24789099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	3
Details	Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	3
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)