9CKV
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CrCneGrvGRhC |
| Chain | Residue | Details |
| B | CYS469-CYS480 | |
| B | CYS559-CYS570 |
| site_id | PS00243 |
| Number of Residues | 14 |
| Details | INTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsNn..GeCvCgqCvC |
| Chain | Residue | Details |
| B | CYS505-CYS518 | |
| B | CYS548-CYS561 | |
| B | CYS587-CYS600 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 707 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | GLN1-ASP708 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | SER132 | |
| B | GLU229 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4 |
| Chain | Residue | Details |
| B | SER134 | |
| A | ASP301 | |
| A | ASP360 | |
| A | ASP362 | |
| A | ASP364 | |
| A | TYR366 | |
| A | ASP368 | |
| A | ASP424 | |
| A | ASP426 | |
| A | ASN428 | |
| A | TYR430 | |
| A | SER241 | |
| A | ASP432 | |
| A | ASP243 | |
| A | THR245 | |
| A | ASP247 | |
| A | ASP293 | |
| A | ASN295 | |
| A | ASP297 | |
| A | LEU299 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASP137 | |
| B | ASP138 | |
| B | ALA342 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4 |
| Chain | Residue | Details |
| B | GLU169 | |
| A | ASN141 | |
| A | ASN275 | |
| A | ASN568 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN224 | |
| B | ASP226 | |
| B | PRO228 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN30 | |
| B | ASN74 | |
| B | ASN77 | |
| B | ASN500 | |
| B | ASN564 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| B | ASN192 | |
| A | ASN552 | |
| A | ASN671 | |
| A | ASN683 | |
| A | ASN827 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN249 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN343 | |
| B | ASN397 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN386 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN461 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD |
| Chain | Residue | Details |
| B | ASN649 |
