9CHP
Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3716 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET241-CYS643 | |
| C | ASP712-SER735 | |
| C | ILE782-ILE787 | |
| D | MET241-CYS643 | |
| D | ASP712-SER735 | |
| D | ILE782-ILE787 | |
| A | ASP712-SER735 | |
| A | ILE782-ILE787 | |
| B | MET241-CYS643 | |
| B | ASP712-SER735 | |
| B | ILE782-ILE787 | |
| C | MET241-CYS643 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL644-GLN664 | |
| B | VAL644-GLN664 | |
| C | VAL644-GLN664 | |
| D | VAL644-GLN664 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 300 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG665-PRO690 | |
| C | LYS757-THR760 | |
| C | LEU809-HIS851 | |
| C | GLN873-PRO878 | |
| D | ARG665-PRO690 | |
| D | LYS757-THR760 | |
| D | LEU809-HIS851 | |
| D | GLN873-PRO878 | |
| A | LYS757-THR760 | |
| A | LEU809-HIS851 | |
| A | GLN873-PRO878 | |
| B | ARG665-PRO690 | |
| B | LYS757-THR760 | |
| B | LEU809-HIS851 | |
| B | GLN873-PRO878 | |
| C | ARG665-PRO690 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN691-ILE711 | |
| B | ASN691-ILE711 | |
| C | ASN691-ILE711 | |
| D | ASN691-ILE711 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU736-MET756 | |
| B | LEU736-MET756 | |
| C | LEU736-MET756 | |
| D | LEU736-MET756 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255 |
| Chain | Residue | Details |
| A | THR761-PHE781 | |
| B | THR761-PHE781 | |
| C | THR761-PHE781 | |
| D | THR761-PHE781 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU788-PRO808 | |
| B | GLU788-PRO808 | |
| C | GLU788-PRO808 | |
| D | GLU788-PRO808 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE852-ARG872 | |
| B | PHE852-ARG872 | |
| C | PHE852-ARG872 | |
| D | PHE852-ARG872 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG879-PRO899 | |
| B | ARG879-PRO899 | |
| C | ARG879-PRO899 | |
| D | ARG879-PRO899 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | CYS982 | |
| B | CYS982 | |
| C | CYS982 | |
| D | CYS982 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ASN479 | |
| D | ASN479 | |
| B | ASN479 | |
| C | ASN479 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35219 |
| Chain | Residue | Details |
| A | VAL483 | |
| C | LEU523 | |
| C | LEU524 | |
| D | VAL483 | |
| D | LEU523 | |
| D | LEU524 | |
| A | LEU523 | |
| A | LEU524 | |
| B | VAL483 | |
| B | LEU523 | |
| B | LEU524 | |
| C | VAL483 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ILE560 | |
| B | ILE560 | |
| C | ILE560 | |
| D | ILE560 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08962 |
| Chain | Residue | Details |
| A | ASP591 | |
| B | ASP591 | |
| C | ASP591 | |
| D | ASP591 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O35219 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12063277 |
| Chain | Residue | Details |
| A | LEU838 | |
| B | LEU838 | |
| C | LEU838 | |
| D | LEU838 |
