9CBT
Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531 |
| Chain | Residue | Details |
| A | HIS248 | |
| B | HIS248 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23897466 |
| Chain | Residue | Details |
| A | GLY145 | |
| A | GLN228 | |
| A | GLY319 | |
| A | ASN344 | |
| B | GLY145 | |
| B | GLN228 | |
| B | GLY319 | |
| B | ASN344 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466 |
| Chain | Residue | Details |
| A | CYS256 | |
| A | CYS259 | |
| A | CYS280 | |
| A | CYS283 | |
| B | CYS256 | |
| B | CYS259 | |
| B | CYS280 | |
| B | CYS283 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104 |
| Chain | Residue | Details |
| A | LYS122 | |
| B | LYS122 |
