9CA8

Cryo-EM structure of human SRCAP-nucleosome complex in the partially-engaged state (composite structure)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000786	cellular_component	nucleosome
A	0000812	cellular_component	Swr1 complex
A	0003677	molecular_function	DNA binding
A	0003713	molecular_function	transcription coactivator activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005794	cellular_component	Golgi apparatus
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010468	biological_process	regulation of gene expression
A	0010557	biological_process	positive regulation of macromolecule biosynthetic process
A	0016604	cellular_component	nuclear body
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0032991	cellular_component	protein-containing complex
A	0042393	molecular_function	histone binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0140096	molecular_function	catalytic activity, acting on a protein
A	0140658	molecular_function	ATP-dependent chromatin remodeler activity
A	0141156	biological_process	cAMP/PKA signal transduction
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016607	cellular_component	nuclear speck
B	0032991	cellular_component	protein-containing complex
B	0035019	biological_process	somatic stem cell population maintenance
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0042393	molecular_function	histone binding
B	0042981	biological_process	regulation of apoptotic process
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051726	biological_process	regulation of cell cycle
B	0140713	molecular_function	histone chaperone activity
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2000779	biological_process	regulation of double-strand break repair
C	0000786	cellular_component	nucleosome
C	0000812	cellular_component	Swr1 complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005856	cellular_component	cytoskeleton
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007000	biological_process	nucleolus organization
C	0016479	biological_process	negative regulation of transcription by RNA polymerase I
C	0031491	molecular_function	nucleosome binding
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000786	cellular_component	nucleosome
D	0000812	cellular_component	Swr1 complex
D	0003015	biological_process	heart process
D	0003682	molecular_function	chromatin binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0031491	molecular_function	nucleosome binding
D	0036335	biological_process	intestinal stem cell homeostasis
D	0042129	biological_process	regulation of T cell proliferation
D	0042393	molecular_function	histone binding
D	0042692	biological_process	muscle cell differentiation
D	0042826	molecular_function	histone deacetylase binding
D	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
D	0045815	biological_process	transcription initiation-coupled chromatin remodeling
D	0046872	molecular_function	metal ion binding
D	0055074	biological_process	calcium ion homeostasis
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0061484	biological_process	hematopoietic stem cell homeostasis
D	0070317	biological_process	negative regulation of G0 to G1 transition
D	1905458	biological_process	positive regulation of lymphoid progenitor cell differentiation
E	0000166	molecular_function	nucleotide binding
E	0000492	biological_process	box C/D snoRNP assembly
E	0000723	biological_process	telomere maintenance
E	0000786	cellular_component	nucleosome
E	0000812	cellular_component	Swr1 complex
E	0001094	molecular_function	TFIID-class transcription factor complex binding
E	0003678	molecular_function	DNA helicase activity
E	0003713	molecular_function	transcription coactivator activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006282	biological_process	regulation of DNA repair
E	0006310	biological_process	DNA recombination
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006974	biological_process	DNA damage response
E	0007283	biological_process	spermatogenesis
E	0016020	cellular_component	membrane
E	0016363	cellular_component	nuclear matrix
E	0016607	cellular_component	nuclear speck
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017025	molecular_function	TBP-class protein binding
E	0031011	cellular_component	Ino80 complex
E	0033044	biological_process	regulation of chromosome organization
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0036064	cellular_component	ciliary basal body
E	0042981	biological_process	regulation of apoptotic process
E	0043531	molecular_function	ADP binding
E	0045296	molecular_function	cadherin binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045995	biological_process	regulation of embryonic development
E	0050821	biological_process	protein stabilization
E	0051117	molecular_function	ATPase binding
E	0051301	biological_process	cell division
E	0051726	biological_process	regulation of cell cycle
E	0060382	biological_process	regulation of DNA strand elongation
E	0070062	cellular_component	extracellular exosome
E	0071339	cellular_component	MLL1 complex
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0090671	biological_process	telomerase RNA localization to Cajal body
E	0097255	cellular_component	R2TP complex
E	0101031	cellular_component	protein folding chaperone complex
E	0120293	cellular_component	dynein axonemal particle
E	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
E	1990904	cellular_component	ribonucleoprotein complex
E	2000779	biological_process	regulation of double-strand break repair
F	0000166	molecular_function	nucleotide binding
F	0000492	biological_process	box C/D snoRNP assembly
F	0000723	biological_process	telomere maintenance
F	0000786	cellular_component	nucleosome
F	0000791	cellular_component	euchromatin
F	0000812	cellular_component	Swr1 complex
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003678	molecular_function	DNA helicase activity
F	0003714	molecular_function	transcription corepressor activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006282	biological_process	regulation of DNA repair
F	0006310	biological_process	DNA recombination
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006457	biological_process	protein folding
F	0006974	biological_process	DNA damage response
F	0008013	molecular_function	beta-catenin binding
F	0016020	cellular_component	membrane
F	0016363	cellular_component	nuclear matrix
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017025	molecular_function	TBP-class protein binding
F	0031011	cellular_component	Ino80 complex
F	0031490	molecular_function	chromatin DNA binding
F	0033044	biological_process	regulation of chromosome organization
F	0034644	biological_process	cellular response to UV
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0036064	cellular_component	ciliary basal body
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042981	biological_process	regulation of apoptotic process
F	0043531	molecular_function	ADP binding
F	0045739	biological_process	positive regulation of DNA repair
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0045995	biological_process	regulation of embryonic development
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
F	0051117	molecular_function	ATPase binding
F	0051726	biological_process	regulation of cell cycle
F	0060382	biological_process	regulation of DNA strand elongation
F	0070062	cellular_component	extracellular exosome
F	0071169	biological_process	establishment of protein localization to chromatin
F	0071339	cellular_component	MLL1 complex
F	0071392	biological_process	cellular response to estradiol stimulus
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0090671	biological_process	telomerase RNA localization to Cajal body
F	0097255	cellular_component	R2TP complex
F	0101031	cellular_component	protein folding chaperone complex
F	0120293	cellular_component	dynein axonemal particle
F	0140585	molecular_function	promoter-enhancer loop anchoring activity
F	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	1990904	cellular_component	ribonucleoprotein complex
F	2000779	biological_process	regulation of double-strand break repair
G	0000166	molecular_function	nucleotide binding
G	0000492	biological_process	box C/D snoRNP assembly
G	0000723	biological_process	telomere maintenance
G	0000786	cellular_component	nucleosome
G	0000812	cellular_component	Swr1 complex
G	0001094	molecular_function	TFIID-class transcription factor complex binding
G	0003678	molecular_function	DNA helicase activity
G	0003713	molecular_function	transcription coactivator activity
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006275	biological_process	regulation of DNA replication
G	0006281	biological_process	DNA repair
G	0006282	biological_process	regulation of DNA repair
G	0006310	biological_process	DNA recombination
G	0006325	biological_process	chromatin organization
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0016020	cellular_component	membrane
G	0016363	cellular_component	nuclear matrix
G	0016607	cellular_component	nuclear speck
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0017025	molecular_function	TBP-class protein binding
G	0031011	cellular_component	Ino80 complex
G	0033044	biological_process	regulation of chromosome organization
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
G	0036064	cellular_component	ciliary basal body
G	0042981	biological_process	regulation of apoptotic process
G	0043531	molecular_function	ADP binding
G	0045296	molecular_function	cadherin binding
G	0045739	biological_process	positive regulation of DNA repair
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0045995	biological_process	regulation of embryonic development
G	0050821	biological_process	protein stabilization
G	0051117	molecular_function	ATPase binding
G	0051301	biological_process	cell division
G	0051726	biological_process	regulation of cell cycle
G	0060382	biological_process	regulation of DNA strand elongation
G	0070062	cellular_component	extracellular exosome
G	0071339	cellular_component	MLL1 complex
G	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
G	0090671	biological_process	telomerase RNA localization to Cajal body
G	0097255	cellular_component	R2TP complex
G	0101031	cellular_component	protein folding chaperone complex
G	0120293	cellular_component	dynein axonemal particle
G	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
G	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
G	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
G	1990904	cellular_component	ribonucleoprotein complex
G	2000779	biological_process	regulation of double-strand break repair
H	0000166	molecular_function	nucleotide binding
H	0000492	biological_process	box C/D snoRNP assembly
H	0000723	biological_process	telomere maintenance
H	0000786	cellular_component	nucleosome
H	0000791	cellular_component	euchromatin
H	0000812	cellular_component	Swr1 complex
H	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
H	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
H	0001094	molecular_function	TFIID-class transcription factor complex binding
H	0003678	molecular_function	DNA helicase activity
H	0003714	molecular_function	transcription corepressor activity
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0006275	biological_process	regulation of DNA replication
H	0006281	biological_process	DNA repair
H	0006282	biological_process	regulation of DNA repair
H	0006310	biological_process	DNA recombination
H	0006325	biological_process	chromatin organization
H	0006338	biological_process	chromatin remodeling
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006457	biological_process	protein folding
H	0006974	biological_process	DNA damage response
H	0008013	molecular_function	beta-catenin binding
H	0016020	cellular_component	membrane
H	0016363	cellular_component	nuclear matrix
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0017025	molecular_function	TBP-class protein binding
H	0031011	cellular_component	Ino80 complex
H	0031490	molecular_function	chromatin DNA binding
H	0033044	biological_process	regulation of chromosome organization
H	0034644	biological_process	cellular response to UV
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036064	cellular_component	ciliary basal body
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042981	biological_process	regulation of apoptotic process
H	0043531	molecular_function	ADP binding
H	0045739	biological_process	positive regulation of DNA repair
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0045995	biological_process	regulation of embryonic development
H	0050821	biological_process	protein stabilization
H	0051082	molecular_function	unfolded protein binding
H	0051117	molecular_function	ATPase binding
H	0051726	biological_process	regulation of cell cycle
H	0060382	biological_process	regulation of DNA strand elongation
H	0070062	cellular_component	extracellular exosome
H	0071169	biological_process	establishment of protein localization to chromatin
H	0071339	cellular_component	MLL1 complex
H	0071392	biological_process	cellular response to estradiol stimulus
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090671	biological_process	telomerase RNA localization to Cajal body
H	0097255	cellular_component	R2TP complex
H	0101031	cellular_component	protein folding chaperone complex
H	0120293	cellular_component	dynein axonemal particle
H	0140585	molecular_function	promoter-enhancer loop anchoring activity
H	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
H	1990904	cellular_component	ribonucleoprotein complex
H	2000779	biological_process	regulation of double-strand break repair
I	0000166	molecular_function	nucleotide binding
I	0000492	biological_process	box C/D snoRNP assembly
I	0000723	biological_process	telomere maintenance
I	0000786	cellular_component	nucleosome
I	0000812	cellular_component	Swr1 complex
I	0001094	molecular_function	TFIID-class transcription factor complex binding
I	0003678	molecular_function	DNA helicase activity
I	0003713	molecular_function	transcription coactivator activity
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0006275	biological_process	regulation of DNA replication
I	0006281	biological_process	DNA repair
I	0006282	biological_process	regulation of DNA repair
I	0006310	biological_process	DNA recombination
I	0006325	biological_process	chromatin organization
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006974	biological_process	DNA damage response
I	0007283	biological_process	spermatogenesis
I	0016020	cellular_component	membrane
I	0016363	cellular_component	nuclear matrix
I	0016607	cellular_component	nuclear speck
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0017025	molecular_function	TBP-class protein binding
I	0031011	cellular_component	Ino80 complex
I	0033044	biological_process	regulation of chromosome organization
I	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0036064	cellular_component	ciliary basal body
I	0042981	biological_process	regulation of apoptotic process
I	0043531	molecular_function	ADP binding
I	0045296	molecular_function	cadherin binding
I	0045739	biological_process	positive regulation of DNA repair
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045995	biological_process	regulation of embryonic development
I	0050821	biological_process	protein stabilization
I	0051117	molecular_function	ATPase binding
I	0051301	biological_process	cell division
I	0051726	biological_process	regulation of cell cycle
I	0060382	biological_process	regulation of DNA strand elongation
I	0070062	cellular_component	extracellular exosome
I	0071339	cellular_component	MLL1 complex
I	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
I	0090671	biological_process	telomerase RNA localization to Cajal body
I	0097255	cellular_component	R2TP complex
I	0101031	cellular_component	protein folding chaperone complex
I	0120293	cellular_component	dynein axonemal particle
I	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
I	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
I	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
I	1990904	cellular_component	ribonucleoprotein complex
I	2000779	biological_process	regulation of double-strand break repair
J	0000166	molecular_function	nucleotide binding
J	0000492	biological_process	box C/D snoRNP assembly
J	0000723	biological_process	telomere maintenance
J	0000786	cellular_component	nucleosome
J	0000791	cellular_component	euchromatin
J	0000812	cellular_component	Swr1 complex
J	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
J	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
J	0001094	molecular_function	TFIID-class transcription factor complex binding
J	0003678	molecular_function	DNA helicase activity
J	0003714	molecular_function	transcription corepressor activity
J	0004386	molecular_function	helicase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0006275	biological_process	regulation of DNA replication
J	0006281	biological_process	DNA repair
J	0006282	biological_process	regulation of DNA repair
J	0006310	biological_process	DNA recombination
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006457	biological_process	protein folding
J	0006974	biological_process	DNA damage response
J	0008013	molecular_function	beta-catenin binding
J	0016020	cellular_component	membrane
J	0016363	cellular_component	nuclear matrix
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0017025	molecular_function	TBP-class protein binding
J	0031011	cellular_component	Ino80 complex
J	0031490	molecular_function	chromatin DNA binding
J	0033044	biological_process	regulation of chromosome organization
J	0034644	biological_process	cellular response to UV
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0036064	cellular_component	ciliary basal body
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0042981	biological_process	regulation of apoptotic process
J	0043531	molecular_function	ADP binding
J	0045739	biological_process	positive regulation of DNA repair
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0045995	biological_process	regulation of embryonic development
J	0050821	biological_process	protein stabilization
J	0051082	molecular_function	unfolded protein binding
J	0051117	molecular_function	ATPase binding
J	0051726	biological_process	regulation of cell cycle
J	0060382	biological_process	regulation of DNA strand elongation
J	0070062	cellular_component	extracellular exosome
J	0071169	biological_process	establishment of protein localization to chromatin
J	0071339	cellular_component	MLL1 complex
J	0071392	biological_process	cellular response to estradiol stimulus
J	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
J	0090671	biological_process	telomerase RNA localization to Cajal body
J	0097255	cellular_component	R2TP complex
J	0101031	cellular_component	protein folding chaperone complex
J	0120293	cellular_component	dynein axonemal particle
J	0140585	molecular_function	promoter-enhancer loop anchoring activity
J	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
J	1990904	cellular_component	ribonucleoprotein complex
J	2000779	biological_process	regulation of double-strand break repair
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0030527	molecular_function	structural constituent of chromatin
Q	0031507	biological_process	heterochromatin formation
R	0000786	cellular_component	nucleosome
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005694	cellular_component	chromosome
R	0030527	molecular_function	structural constituent of chromatin
S	0000786	cellular_component	nucleosome
S	0003677	molecular_function	DNA binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0030527	molecular_function	structural constituent of chromatin
S	0031507	biological_process	heterochromatin formation
T	0000786	cellular_component	nucleosome
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005694	cellular_component	chromosome
T	0030527	molecular_function	structural constituent of chromatin
U	0000786	cellular_component	nucleosome
U	0003677	molecular_function	DNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005694	cellular_component	chromosome
U	0030527	molecular_function	structural constituent of chromatin
V	0000786	cellular_component	nucleosome
V	0003677	molecular_function	DNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005694	cellular_component	chromosome
V	0006334	biological_process	nucleosome assembly
V	0030527	molecular_function	structural constituent of chromatin
W	0000786	cellular_component	nucleosome
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
W	0030527	molecular_function	structural constituent of chromatin
X	0000786	cellular_component	nucleosome
X	0003677	molecular_function	DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005694	cellular_component	chromosome
X	0006334	biological_process	nucleosome assembly
X	0030527	molecular_function	structural constituent of chromatin

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
Q	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
V	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
U	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
R	ARG92-GLY114

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
U	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	165
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	153
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	32
Details	Zinc finger: {"description":"HIT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00453","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	9
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"17892483","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00453","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAPK11 and MAPK14","evidences":[{"source":"PubMed","id":"17380123","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	21
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P0C0S8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P0C1H4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P84228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	4
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---