9C9T

S.c INO80 in complex with S.c 0/40 nucleosome, Class 2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000500	cellular_component	RNA polymerase I upstream activating factor complex
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006878	biological_process	intracellular copper ion homeostasis
A	0008823	molecular_function	cupric reductase (NADH) activity
A	0009060	biological_process	aerobic respiration
A	0009303	biological_process	rRNA transcription
A	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
A	0043505	cellular_component	CENP-A containing nucleosome
A	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
A	0045943	biological_process	positive regulation of transcription by RNA polymerase I
A	0070911	biological_process	global genome nucleotide-excision repair
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0006974	biological_process	DNA damage response
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006301	biological_process	DNA damage tolerance
D	0006325	biological_process	chromatin organization
D	0006355	biological_process	regulation of DNA-templated transcription
E	0000500	cellular_component	RNA polymerase I upstream activating factor complex
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006878	biological_process	intracellular copper ion homeostasis
E	0008823	molecular_function	cupric reductase (NADH) activity
E	0009060	biological_process	aerobic respiration
E	0009303	biological_process	rRNA transcription
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0043505	cellular_component	CENP-A containing nucleosome
E	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
E	0045943	biological_process	positive regulation of transcription by RNA polymerase I
E	0070911	biological_process	global genome nucleotide-excision repair
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006281	biological_process	DNA repair
G	0006325	biological_process	chromatin organization
G	0006974	biological_process	DNA damage response
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006301	biological_process	DNA damage tolerance
H	0006325	biological_process	chromatin organization
H	0006355	biological_process	regulation of DNA-templated transcription
Q	0000166	molecular_function	nucleotide binding
Q	0000722	biological_process	telomere maintenance via recombination
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000781	cellular_component	chromosome, telomeric region
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0006281	biological_process	DNA repair
Q	0006338	biological_process	chromatin remodeling
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0006974	biological_process	DNA damage response
Q	0010557	biological_process	positive regulation of macromolecule biosynthetic process
Q	0016787	molecular_function	hydrolase activity
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0031011	cellular_component	Ino80 complex
Q	0031509	biological_process	subtelomeric heterochromatin formation
Q	0032006	biological_process	regulation of TOR signaling
Q	0033554	biological_process	cellular response to stress
Q	0040029	biological_process	epigenetic regulation of gene expression
Q	0042393	molecular_function	histone binding
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0051276	biological_process	chromosome organization
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0006281	biological_process	DNA repair
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0030234	molecular_function	enzyme regulator activity
R	0031011	cellular_component	Ino80 complex
S	0003674	molecular_function	molecular_function
S	0005634	cellular_component	nucleus
S	0006281	biological_process	DNA repair
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0008150	biological_process	biological_process
S	0031011	cellular_component	Ino80 complex
T	0000166	molecular_function	nucleotide binding
T	0000492	biological_process	box C/D snoRNP assembly
T	0000785	cellular_component	chromatin
T	0000812	cellular_component	Swr1 complex
T	0003678	molecular_function	DNA helicase activity
T	0004386	molecular_function	helicase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0006281	biological_process	DNA repair
T	0006325	biological_process	chromatin organization
T	0006338	biological_process	chromatin remodeling
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006974	biological_process	DNA damage response
T	0016787	molecular_function	hydrolase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0031011	cellular_component	Ino80 complex
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
T	0043138	molecular_function	3'-5' DNA helicase activity
T	0043139	molecular_function	5'-3' DNA helicase activity
T	0050821	biological_process	protein stabilization
T	0097255	cellular_component	R2TP complex
T	0110078	cellular_component	TTT Hsp90 cochaperone complex
U	0000166	molecular_function	nucleotide binding
U	0000492	biological_process	box C/D snoRNP assembly
U	0000785	cellular_component	chromatin
U	0000812	cellular_component	Swr1 complex
U	0003678	molecular_function	DNA helicase activity
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006281	biological_process	DNA repair
U	0006325	biological_process	chromatin organization
U	0006338	biological_process	chromatin remodeling
U	0006355	biological_process	regulation of DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0006364	biological_process	rRNA processing
U	0006974	biological_process	DNA damage response
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0031011	cellular_component	Ino80 complex
U	0035267	cellular_component	NuA4 histone acetyltransferase complex
U	0043138	molecular_function	3'-5' DNA helicase activity
U	0043139	molecular_function	5'-3' DNA helicase activity
U	0050821	biological_process	protein stabilization
U	0097255	cellular_component	R2TP complex
U	0110078	cellular_component	TTT Hsp90 cochaperone complex
V	0000166	molecular_function	nucleotide binding
V	0000492	biological_process	box C/D snoRNP assembly
V	0000785	cellular_component	chromatin
V	0000812	cellular_component	Swr1 complex
V	0003678	molecular_function	DNA helicase activity
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0006281	biological_process	DNA repair
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0006974	biological_process	DNA damage response
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0031011	cellular_component	Ino80 complex
V	0035267	cellular_component	NuA4 histone acetyltransferase complex
V	0043138	molecular_function	3'-5' DNA helicase activity
V	0043139	molecular_function	5'-3' DNA helicase activity
V	0050821	biological_process	protein stabilization
V	0097255	cellular_component	R2TP complex
V	0110078	cellular_component	TTT Hsp90 cochaperone complex
W	0000166	molecular_function	nucleotide binding
W	0000492	biological_process	box C/D snoRNP assembly
W	0000785	cellular_component	chromatin
W	0000812	cellular_component	Swr1 complex
W	0003678	molecular_function	DNA helicase activity
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0006281	biological_process	DNA repair
W	0006325	biological_process	chromatin organization
W	0006338	biological_process	chromatin remodeling
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006364	biological_process	rRNA processing
W	0006974	biological_process	DNA damage response
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0031011	cellular_component	Ino80 complex
W	0035267	cellular_component	NuA4 histone acetyltransferase complex
W	0043138	molecular_function	3'-5' DNA helicase activity
W	0043139	molecular_function	5'-3' DNA helicase activity
W	0050821	biological_process	protein stabilization
W	0097255	cellular_component	R2TP complex
W	0110078	cellular_component	TTT Hsp90 cochaperone complex
X	0000166	molecular_function	nucleotide binding
X	0000492	biological_process	box C/D snoRNP assembly
X	0000785	cellular_component	chromatin
X	0000812	cellular_component	Swr1 complex
X	0003678	molecular_function	DNA helicase activity
X	0004386	molecular_function	helicase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0006281	biological_process	DNA repair
X	0006325	biological_process	chromatin organization
X	0006338	biological_process	chromatin remodeling
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006974	biological_process	DNA damage response
X	0016787	molecular_function	hydrolase activity
X	0016887	molecular_function	ATP hydrolysis activity
X	0031011	cellular_component	Ino80 complex
X	0035267	cellular_component	NuA4 histone acetyltransferase complex
X	0043138	molecular_function	3'-5' DNA helicase activity
X	0043139	molecular_function	5'-3' DNA helicase activity
X	0050821	biological_process	protein stabilization
X	0097255	cellular_component	R2TP complex
X	0110078	cellular_component	TTT Hsp90 cochaperone complex
Y	0000166	molecular_function	nucleotide binding
Y	0000492	biological_process	box C/D snoRNP assembly
Y	0000785	cellular_component	chromatin
Y	0000812	cellular_component	Swr1 complex
Y	0003678	molecular_function	DNA helicase activity
Y	0004386	molecular_function	helicase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006281	biological_process	DNA repair
Y	0006325	biological_process	chromatin organization
Y	0006338	biological_process	chromatin remodeling
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0006364	biological_process	rRNA processing
Y	0006974	biological_process	DNA damage response
Y	0016787	molecular_function	hydrolase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0031011	cellular_component	Ino80 complex
Y	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	0043138	molecular_function	3'-5' DNA helicase activity
Y	0043139	molecular_function	5'-3' DNA helicase activity
Y	0050821	biological_process	protein stabilization
Y	0097255	cellular_component	R2TP complex
Y	0110078	cellular_component	TTT Hsp90 cochaperone complex
Z	0003674	molecular_function	molecular_function
Z	0003677	molecular_function	DNA binding
Z	0005634	cellular_component	nucleus
Z	0006281	biological_process	DNA repair
Z	0006325	biological_process	chromatin organization
Z	0006338	biological_process	chromatin remodeling
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0006974	biological_process	DNA damage response
Z	0008150	biological_process	biological_process
Z	0031011	cellular_component	Ino80 complex

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. SQEL

Chain	Residue	Details
C	SER128-LEU131

---

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLtFPV

Chain	Residue	Details
C	ALA22-VAL28

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY15-HIS19

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
D	ARG95-GLY117

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Not ubiquitinated","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2201907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	5
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-malonyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16432255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	172
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	Motif: {"description":"DEAQ box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---