9C8U
Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 24 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H |
| Chain | Residue | Details |
| F | CYS55-HIS78 | |
| F | CYS122-HIS144 | |
| B | CYS450-HIS471 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| C | LEU206-ILE220 | |
| D | LEU193-ILE207 | |
| D | LEU289-LEU303 | |
| D | LEU333-LEU347 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| F | TYR53-HIS78 | |
| C | LYS268 | |
| C | LYS284 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 2; degenerate => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| F | LYS92-HIS114 | |
| A | LEU363 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| F | PHE120-HIS144 | |
| B | SER541 | |
| B | SER726 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| F | SER2 | |
| F | SER3 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| F | SER182 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER367 | |
| B | LYS73 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ALA487 | |
| D | LYS160 | |
| B | LYS390 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:24474760 |
| Chain | Residue | Details |
| A | SER75 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS634 |
