9C6S

18-mer blood cell-specific tubulin in complex with Cryptophycin-52

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0030182	biological_process	neuron differentiation
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
c	0000166	molecular_function	nucleotide binding
c	0000226	biological_process	microtubule cytoskeleton organization
c	0000278	biological_process	mitotic cell cycle
c	0005200	molecular_function	structural constituent of cytoskeleton
c	0005525	molecular_function	GTP binding
c	0005737	cellular_component	cytoplasm
c	0005856	cellular_component	cytoskeleton
c	0005874	cellular_component	microtubule
c	0007017	biological_process	microtubule-based process
c	0016787	molecular_function	hydrolase activity
c	0030182	biological_process	neuron differentiation
c	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0030182	biological_process	neuron differentiation
C	0046872	molecular_function	metal ion binding
d	0000166	molecular_function	nucleotide binding
d	0000226	biological_process	microtubule cytoskeleton organization
d	0000278	biological_process	mitotic cell cycle
d	0003924	molecular_function	GTPase activity
d	0005200	molecular_function	structural constituent of cytoskeleton
d	0005525	molecular_function	GTP binding
d	0005737	cellular_component	cytoplasm
d	0005856	cellular_component	cytoskeleton
d	0005874	cellular_component	microtubule
d	0007017	biological_process	microtubule-based process
d	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0046872	molecular_function	metal ion binding
g	0000166	molecular_function	nucleotide binding
g	0000226	biological_process	microtubule cytoskeleton organization
g	0000278	biological_process	mitotic cell cycle
g	0005200	molecular_function	structural constituent of cytoskeleton
g	0005525	molecular_function	GTP binding
g	0005737	cellular_component	cytoplasm
g	0005856	cellular_component	cytoskeleton
g	0005874	cellular_component	microtubule
g	0007017	biological_process	microtubule-based process
g	0016787	molecular_function	hydrolase activity
g	0030182	biological_process	neuron differentiation
g	0046872	molecular_function	metal ion binding
h	0000166	molecular_function	nucleotide binding
h	0000226	biological_process	microtubule cytoskeleton organization
h	0000278	biological_process	mitotic cell cycle
h	0003924	molecular_function	GTPase activity
h	0005200	molecular_function	structural constituent of cytoskeleton
h	0005525	molecular_function	GTP binding
h	0005737	cellular_component	cytoplasm
h	0005856	cellular_component	cytoskeleton
h	0005874	cellular_component	microtubule
h	0007017	biological_process	microtubule-based process
h	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0016787	molecular_function	hydrolase activity
I	0030182	biological_process	neuron differentiation
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0016787	molecular_function	hydrolase activity
M	0030182	biological_process	neuron differentiation
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0016787	molecular_function	hydrolase activity
Q	0030182	biological_process	neuron differentiation
Q	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0046872	molecular_function	metal ion binding
U	0000166	molecular_function	nucleotide binding
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000278	biological_process	mitotic cell cycle
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005525	molecular_function	GTP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005874	cellular_component	microtubule
U	0007017	biological_process	microtubule-based process
U	0016787	molecular_function	hydrolase activity
U	0030182	biological_process	neuron differentiation
U	0046872	molecular_function	metal ion binding
V	0000166	molecular_function	nucleotide binding
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000278	biological_process	mitotic cell cycle
V	0003924	molecular_function	GTPase activity
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005525	molecular_function	GTP binding
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005874	cellular_component	microtubule
V	0007017	biological_process	microtubule-based process
V	0046872	molecular_function	metal ion binding
Y	0000166	molecular_function	nucleotide binding
Y	0000226	biological_process	microtubule cytoskeleton organization
Y	0000278	biological_process	mitotic cell cycle
Y	0005200	molecular_function	structural constituent of cytoskeleton
Y	0005525	molecular_function	GTP binding
Y	0005737	cellular_component	cytoplasm
Y	0005856	cellular_component	cytoskeleton
Y	0005874	cellular_component	microtubule
Y	0007017	biological_process	microtubule-based process
Y	0016787	molecular_function	hydrolase activity
Y	0030182	biological_process	neuron differentiation
Y	0046872	molecular_function	metal ion binding
Z	0000166	molecular_function	nucleotide binding
Z	0000226	biological_process	microtubule cytoskeleton organization
Z	0000278	biological_process	mitotic cell cycle
Z	0003924	molecular_function	GTPase activity
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005525	molecular_function	GTP binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005874	cellular_component	microtubule
Z	0007017	biological_process	microtubule-based process
Z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	81
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	27
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	63
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---