9C6R

Blood cell-specific tubulin in complex with Cryptophycin-52

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000166	molecular_function	nucleotide binding
a	0000226	biological_process	microtubule cytoskeleton organization
a	0000278	biological_process	mitotic cell cycle
a	0003924	molecular_function	GTPase activity
a	0005200	molecular_function	structural constituent of cytoskeleton
a	0005525	molecular_function	GTP binding
a	0005737	cellular_component	cytoplasm
a	0005856	cellular_component	cytoskeleton
a	0005874	cellular_component	microtubule
a	0007017	biological_process	microtubule-based process
a	0046872	molecular_function	metal ion binding
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0030182	biological_process	neuron differentiation
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
e	0000166	molecular_function	nucleotide binding
e	0000226	biological_process	microtubule cytoskeleton organization
e	0000278	biological_process	mitotic cell cycle
e	0005200	molecular_function	structural constituent of cytoskeleton
e	0005525	molecular_function	GTP binding
e	0005737	cellular_component	cytoplasm
e	0005856	cellular_component	cytoskeleton
e	0005874	cellular_component	microtubule
e	0007017	biological_process	microtubule-based process
e	0016787	molecular_function	hydrolase activity
e	0030182	biological_process	neuron differentiation
e	0046872	molecular_function	metal ion binding
f	0000166	molecular_function	nucleotide binding
f	0000226	biological_process	microtubule cytoskeleton organization
f	0000278	biological_process	mitotic cell cycle
f	0003924	molecular_function	GTPase activity
f	0005200	molecular_function	structural constituent of cytoskeleton
f	0005525	molecular_function	GTP binding
f	0005737	cellular_component	cytoplasm
f	0005856	cellular_component	cytoskeleton
f	0005874	cellular_component	microtubule
f	0007017	biological_process	microtubule-based process
f	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0016787	molecular_function	hydrolase activity
F	0030182	biological_process	neuron differentiation
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003924	molecular_function	GTPase activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0046872	molecular_function	metal ion binding
j	0000166	molecular_function	nucleotide binding
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000278	biological_process	mitotic cell cycle
j	0005200	molecular_function	structural constituent of cytoskeleton
j	0005525	molecular_function	GTP binding
j	0005737	cellular_component	cytoplasm
j	0005856	cellular_component	cytoskeleton
j	0005874	cellular_component	microtubule
j	0007017	biological_process	microtubule-based process
j	0016787	molecular_function	hydrolase activity
j	0030182	biological_process	neuron differentiation
j	0046872	molecular_function	metal ion binding
k	0000166	molecular_function	nucleotide binding
k	0000226	biological_process	microtubule cytoskeleton organization
k	0000278	biological_process	mitotic cell cycle
k	0003924	molecular_function	GTPase activity
k	0005200	molecular_function	structural constituent of cytoskeleton
k	0005525	molecular_function	GTP binding
k	0005737	cellular_component	cytoplasm
k	0005856	cellular_component	cytoskeleton
k	0005874	cellular_component	microtubule
k	0007017	biological_process	microtubule-based process
k	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0016787	molecular_function	hydrolase activity
K	0030182	biological_process	neuron differentiation
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0016787	molecular_function	hydrolase activity
P	0030182	biological_process	neuron differentiation
P	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0046872	molecular_function	metal ion binding
U	0000166	molecular_function	nucleotide binding
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000278	biological_process	mitotic cell cycle
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005525	molecular_function	GTP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005874	cellular_component	microtubule
U	0007017	biological_process	microtubule-based process
U	0016787	molecular_function	hydrolase activity
U	0030182	biological_process	neuron differentiation
U	0046872	molecular_function	metal ion binding
V	0000166	molecular_function	nucleotide binding
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000278	biological_process	mitotic cell cycle
V	0003924	molecular_function	GTPase activity
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005525	molecular_function	GTP binding
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005874	cellular_component	microtubule
V	0007017	biological_process	microtubule-based process
V	0046872	molecular_function	metal ion binding
Z	0000166	molecular_function	nucleotide binding
Z	0000226	biological_process	microtubule cytoskeleton organization
Z	0000278	biological_process	mitotic cell cycle
Z	0005200	molecular_function	structural constituent of cytoskeleton
Z	0005525	molecular_function	GTP binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005874	cellular_component	microtubule
Z	0007017	biological_process	microtubule-based process
Z	0016787	molecular_function	hydrolase activity
Z	0030182	biological_process	neuron differentiation
Z	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---