Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9C6N

ARP module of the human TIP60 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000166	molecular_function	nucleotide binding
G	0000786	cellular_component	nucleosome
G	0000812	cellular_component	Swr1 complex
G	0003677	molecular_function	DNA binding
G	0003682	molecular_function	chromatin binding
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0006281	biological_process	DNA repair
G	0006325	biological_process	chromatin organization
G	0016607	cellular_component	nuclear speck
G	0016787	molecular_function	hydrolase activity
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
G	0042981	biological_process	regulation of apoptotic process
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0051726	biological_process	regulation of cell cycle
G	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
G	1990405	molecular_function	protein antigen binding
G	2000779	biological_process	regulation of double-strand break repair
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000724	biological_process	double-strand break repair via homologous recombination
H	0000786	cellular_component	nucleosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006325	biological_process	chromatin organization
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0007283	biological_process	spermatogenesis
H	0007286	biological_process	spermatid development
H	0016604	cellular_component	nuclear body
H	0030154	biological_process	cell differentiation
H	0031965	cellular_component	nuclear membrane
H	0032777	cellular_component	piccolo histone acetyltransferase complex
H	0035092	biological_process	sperm DNA condensation
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0035861	cellular_component	site of double-strand break
H	0042981	biological_process	regulation of apoptotic process
H	0045814	biological_process	negative regulation of gene expression, epigenetic
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0051726	biological_process	regulation of cell cycle
H	0140463	molecular_function	chromatin-protein adaptor activity
H	0140767	molecular_function	enzyme-substrate adaptor activity
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	2000779	biological_process	regulation of double-strand break repair
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000786	cellular_component	nucleosome
I	0000812	cellular_component	Swr1 complex
I	0003714	molecular_function	transcription corepressor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005657	cellular_component	replication fork
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006325	biological_process	chromatin organization
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0035267	cellular_component	NuA4 histone acetyltransferase complex
I	0042307	biological_process	positive regulation of protein import into nucleus
I	0042981	biological_process	regulation of apoptotic process
I	0045471	biological_process	response to ethanol
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0051726	biological_process	regulation of cell cycle
I	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
I	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
I	2000779	biological_process	regulation of double-strand break repair
J	0000166	molecular_function	nucleotide binding
J	0000776	cellular_component	kinetochore
J	0000785	cellular_component	chromatin
J	0000786	cellular_component	nucleosome
J	0001738	biological_process	morphogenesis of a polarized epithelium
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0005886	cellular_component	plasma membrane
J	0005903	cellular_component	brush border
J	0005911	cellular_component	cell-cell junction
J	0005912	cellular_component	adherens junction
J	0005925	cellular_component	focal adhesion
J	0006338	biological_process	chromatin remodeling
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0007010	biological_process	cytoskeleton organization
J	0007163	biological_process	establishment or maintenance of cell polarity
J	0007409	biological_process	axonogenesis
J	0008284	biological_process	positive regulation of cell population proliferation
J	0015629	cellular_component	actin cytoskeleton
J	0016020	cellular_component	membrane
J	0016363	cellular_component	nuclear matrix
J	0016514	cellular_component	SWI/SNF complex
J	0016586	cellular_component	RSC-type complex
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019894	molecular_function	kinesin binding
J	0019901	molecular_function	protein kinase binding
J	0021762	biological_process	substantia nigra development
J	0030027	cellular_component	lamellipodium
J	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030424	cellular_component	axon
J	0030863	cellular_component	cortical cytoskeleton
J	0030957	molecular_function	Tat protein binding
J	0031492	molecular_function	nucleosomal DNA binding
J	0031982	cellular_component	vesicle
J	0032991	cellular_component	protein-containing complex
J	0034333	biological_process	adherens junction assembly
J	0035060	cellular_component	brahma complex
J	0035267	cellular_component	NuA4 histone acetyltransferase complex
J	0035633	biological_process	maintenance of blood-brain barrier
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0042802	molecular_function	identical protein binding
J	0042981	biological_process	regulation of apoptotic process
J	0043296	cellular_component	apical junction complex
J	0044305	cellular_component	calyx of Held
J	0045176	biological_process	apical protein localization
J	0045202	cellular_component	synapse
J	0045582	biological_process	positive regulation of T cell differentiation
J	0045596	biological_process	negative regulation of cell differentiation
J	0045597	biological_process	positive regulation of cell differentiation
J	0045663	biological_process	positive regulation of myoblast differentiation
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0048156	molecular_function	tau protein binding
J	0048870	biological_process	cell motility
J	0050998	molecular_function	nitric-oxide synthase binding
J	0051621	biological_process	regulation of norepinephrine uptake
J	0051623	biological_process	positive regulation of norepinephrine uptake
J	0051726	biological_process	regulation of cell cycle
J	0070062	cellular_component	extracellular exosome
J	0070160	cellular_component	tight junction
J	0070316	biological_process	regulation of G0 to G1 transition
J	0070527	biological_process	platelet aggregation
J	0071564	cellular_component	npBAF complex
J	0071565	cellular_component	nBAF complex
J	0071896	biological_process	protein localization to adherens junction
J	0072562	cellular_component	blood microparticle
J	0072749	biological_process	cellular response to cytochalasin B
J	0097433	cellular_component	dense body
J	0098685	cellular_component	Schaffer collateral - CA1 synapse
J	0098793	cellular_component	presynapse
J	0098871	cellular_component	postsynaptic actin cytoskeleton
J	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
J	0098974	biological_process	postsynaptic actin cytoskeleton organization
J	0098978	cellular_component	glutamatergic synapse
J	0140092	cellular_component	bBAF complex
J	0140288	cellular_component	GBAF complex
J	0141108	molecular_function	transporter regulator activity
J	0150111	biological_process	regulation of transepithelial transport
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	1902459	biological_process	positive regulation of stem cell population maintenance
J	1903076	biological_process	regulation of protein localization to plasma membrane
J	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
J	1990904	cellular_component	ribonucleoprotein complex
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
J	2000779	biological_process	regulation of double-strand break repair
J	2000781	biological_process	positive regulation of double-strand break repair
J	2000819	biological_process	regulation of nucleotide-excision repair
L	0000723	biological_process	telomere maintenance
L	0000776	cellular_component	kinetochore
L	0000785	cellular_component	chromatin
L	0000786	cellular_component	nucleosome
L	0001825	biological_process	blastocyst formation
L	0003407	biological_process	neural retina development
L	0003682	molecular_function	chromatin binding
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005886	cellular_component	plasma membrane
L	0006275	biological_process	regulation of DNA replication
L	0006281	biological_process	DNA repair
L	0006282	biological_process	regulation of DNA repair
L	0006310	biological_process	DNA recombination
L	0006325	biological_process	chromatin organization
L	0006338	biological_process	chromatin remodeling
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006974	biological_process	DNA damage response
L	0007165	biological_process	signal transduction
L	0007399	biological_process	nervous system development
L	0008284	biological_process	positive regulation of cell population proliferation
L	0016363	cellular_component	nuclear matrix
L	0016514	cellular_component	SWI/SNF complex
L	0016586	cellular_component	RSC-type complex
L	0021510	biological_process	spinal cord development
L	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
L	0031011	cellular_component	Ino80 complex
L	0031492	molecular_function	nucleosomal DNA binding
L	0032991	cellular_component	protein-containing complex
L	0033044	biological_process	regulation of chromosome organization
L	0035060	cellular_component	brahma complex
L	0035267	cellular_component	NuA4 histone acetyltransferase complex
L	0042981	biological_process	regulation of apoptotic process
L	0045582	biological_process	positive regulation of T cell differentiation
L	0045596	biological_process	negative regulation of cell differentiation
L	0045597	biological_process	positive regulation of cell differentiation
L	0045663	biological_process	positive regulation of myoblast differentiation
L	0045739	biological_process	positive regulation of DNA repair
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045995	biological_process	regulation of embryonic development
L	0048731	biological_process	system development
L	0051726	biological_process	regulation of cell cycle
L	0060382	biological_process	regulation of DNA strand elongation
L	0070316	biological_process	regulation of G0 to G1 transition
L	0071564	cellular_component	npBAF complex
L	0140288	cellular_component	GBAF complex
L	1902459	biological_process	positive regulation of stem cell population maintenance
L	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
L	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
L	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
L	2000779	biological_process	regulation of double-strand break repair
L	2000781	biological_process	positive regulation of double-strand break repair
L	2000819	biological_process	regulation of nucleotide-excision repair

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDSGATHTTA

Chain	Residue	Details
L	LEU168-ALA179

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
J	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYEE

Chain	Residue	Details
L	TRP410-GLU418
J	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
J	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"SANT"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)