9C6G

Mcm double hexamer from human

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000727	biological_process	double-strand break repair via break-induced replication
0	0000781	cellular_component	chromosome, telomeric region
0	0003677	molecular_function	DNA binding
0	0003678	molecular_function	DNA helicase activity
0	0003697	molecular_function	single-stranded DNA binding
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005694	cellular_component	chromosome
0	0006259	biological_process	DNA metabolic process
0	0006260	biological_process	DNA replication
0	0006270	biological_process	DNA replication initiation
0	0006271	biological_process	DNA strand elongation involved in DNA replication
0	0016020	cellular_component	membrane
0	0016887	molecular_function	ATP hydrolysis activity
0	0017116	molecular_function	single-stranded DNA helicase activity
0	0030174	biological_process	regulation of DNA-templated DNA replication initiation
0	0042555	cellular_component	MCM complex
0	0071162	cellular_component	CMG complex
0	1902975	biological_process	mitotic DNA replication initiation
2	0000228	cellular_component	nuclear chromosome
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000781	cellular_component	chromosome, telomeric region
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005664	cellular_component	nuclear origin of replication recognition complex
2	0005694	cellular_component	chromosome
2	0005730	cellular_component	nucleolus
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006915	biological_process	apoptotic process
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0019899	molecular_function	enzyme binding
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0042393	molecular_function	histone binding
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0071162	cellular_component	CMG complex
2	0090102	biological_process	cochlea development
2	1902975	biological_process	mitotic DNA replication initiation
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003697	molecular_function	single-stranded DNA binding
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005658	cellular_component	alpha DNA polymerase:primase complex
3	0005694	cellular_component	chromosome
3	0005730	cellular_component	nucleolus
3	0005737	cellular_component	cytoplasm
3	0006259	biological_process	DNA metabolic process
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0016020	cellular_component	membrane
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0042555	cellular_component	MCM complex
3	0048471	cellular_component	perinuclear region of cytoplasm
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000781	cellular_component	chromosome, telomeric region
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003697	molecular_function	single-stranded DNA binding
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005694	cellular_component	chromosome
4	0006259	biological_process	DNA metabolic process
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0016020	cellular_component	membrane
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0042555	cellular_component	MCM complex
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0016020	cellular_component	membrane
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0071162	cellular_component	CMG complex
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000781	cellular_component	chromosome, telomeric region
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003697	molecular_function	single-stranded DNA binding
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005694	cellular_component	chromosome
6	0006259	biological_process	DNA metabolic process
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0016887	molecular_function	ATP hydrolysis activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0042555	cellular_component	MCM complex
6	0042802	molecular_function	identical protein binding
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003697	molecular_function	single-stranded DNA binding
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005694	cellular_component	chromosome
7	0005730	cellular_component	nucleolus
7	0006259	biological_process	DNA metabolic process
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006974	biological_process	DNA damage response
7	0009410	biological_process	response to xenobiotic stimulus
7	0016020	cellular_component	membrane
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0042325	biological_process	regulation of phosphorylation
7	0042555	cellular_component	MCM complex
7	0071162	cellular_component	CMG complex
7	0071364	biological_process	cellular response to epidermal growth factor stimulus
8	0000228	cellular_component	nuclear chromosome
8	0000727	biological_process	double-strand break repair via break-induced replication
8	0000781	cellular_component	chromosome, telomeric region
8	0000785	cellular_component	chromatin
8	0003677	molecular_function	DNA binding
8	0003678	molecular_function	DNA helicase activity
8	0003688	molecular_function	DNA replication origin binding
8	0003697	molecular_function	single-stranded DNA binding
8	0005515	molecular_function	protein binding
8	0005524	molecular_function	ATP binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005664	cellular_component	nuclear origin of replication recognition complex
8	0005694	cellular_component	chromosome
8	0005730	cellular_component	nucleolus
8	0005737	cellular_component	cytoplasm
8	0006260	biological_process	DNA replication
8	0006270	biological_process	DNA replication initiation
8	0006915	biological_process	apoptotic process
8	0016887	molecular_function	ATP hydrolysis activity
8	0017116	molecular_function	single-stranded DNA helicase activity
8	0019899	molecular_function	enzyme binding
8	0030174	biological_process	regulation of DNA-templated DNA replication initiation
8	0042393	molecular_function	histone binding
8	0042555	cellular_component	MCM complex
8	0043138	molecular_function	3'-5' DNA helicase activity
8	0071162	cellular_component	CMG complex
8	0090102	biological_process	cochlea development
8	1902975	biological_process	mitotic DNA replication initiation
9	0000727	biological_process	double-strand break repair via break-induced replication
9	0000781	cellular_component	chromosome, telomeric region
9	0003677	molecular_function	DNA binding
9	0003678	molecular_function	DNA helicase activity
9	0003697	molecular_function	single-stranded DNA binding
9	0005515	molecular_function	protein binding
9	0005524	molecular_function	ATP binding
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005658	cellular_component	alpha DNA polymerase:primase complex
9	0005694	cellular_component	chromosome
9	0005730	cellular_component	nucleolus
9	0005737	cellular_component	cytoplasm
9	0006259	biological_process	DNA metabolic process
9	0006260	biological_process	DNA replication
9	0006270	biological_process	DNA replication initiation
9	0006271	biological_process	DNA strand elongation involved in DNA replication
9	0016020	cellular_component	membrane
9	0016887	molecular_function	ATP hydrolysis activity
9	0017116	molecular_function	single-stranded DNA helicase activity
9	0030174	biological_process	regulation of DNA-templated DNA replication initiation
9	0042555	cellular_component	MCM complex
9	0048471	cellular_component	perinuclear region of cytoplasm
9	0071162	cellular_component	CMG complex
9	1902975	biological_process	mitotic DNA replication initiation
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003688	molecular_function	DNA replication origin binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006260	biological_process	DNA replication
A	0006270	biological_process	DNA replication initiation
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0042555	cellular_component	MCM complex
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0071162	cellular_component	CMG complex
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006259	biological_process	DNA metabolic process
B	0006260	biological_process	DNA replication
B	0006270	biological_process	DNA replication initiation
B	0016887	molecular_function	ATP hydrolysis activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0042555	cellular_component	MCM complex
B	0042802	molecular_function	identical protein binding
B	0071162	cellular_component	CMG complex
B	1902969	biological_process	mitotic DNA replication
B	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0006259	biological_process	DNA metabolic process
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006974	biological_process	DNA damage response
C	0009410	biological_process	response to xenobiotic stimulus
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0042325	biological_process	regulation of phosphorylation
C	0042555	cellular_component	MCM complex
C	0071162	cellular_component	CMG complex
C	0071364	biological_process	cellular response to epidermal growth factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
3	GLY404-ASP412
7	GLY440-ASP448
5	GLY440-ASP448
6	GLY455-ASP463
0	GLY569-ASP577
2	GLY582-ASP590

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Motif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	70
Details	Motif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Glen H.","Brunton V.G.","Frame M.C."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"40940420","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	86
Details	Region: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---