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9C4E

Structure of endogenous DPYSL2 from rat model of Alzheimer's disease

Functional Information from GO Data
ChainGOidnamespacecontents
A0001975biological_processresponse to amphetamine
A0004157molecular_functiondihydropyrimidinase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0006208biological_processpyrimidine nucleobase catabolic process
A0006897biological_processendocytosis
A0007010biological_processcytoskeleton organization
A0007399biological_processnervous system development
A0009410biological_processresponse to xenobiotic stimulus
A0010975biological_processregulation of neuron projection development
A0014049biological_processpositive regulation of glutamate secretion
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0019901molecular_functionprotein kinase binding
A0021510biological_processspinal cord development
A0021772biological_processolfactory bulb development
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030516biological_processregulation of axon extension
A0032991cellular_componentprotein-containing complex
A0042220biological_processresponse to cocaine
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043209cellular_componentmyelin sheath
A0045202cellular_componentsynapse
A0045664biological_processregulation of neuron differentiation
A0048489biological_processsynaptic vesicle transport
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0120025cellular_componentplasma membrane bounded cell projection
A0150052biological_processregulation of postsynapse assembly
B0001975biological_processresponse to amphetamine
B0004157molecular_functiondihydropyrimidinase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0006208biological_processpyrimidine nucleobase catabolic process
B0006897biological_processendocytosis
B0007010biological_processcytoskeleton organization
B0007399biological_processnervous system development
B0009410biological_processresponse to xenobiotic stimulus
B0010975biological_processregulation of neuron projection development
B0014049biological_processpositive regulation of glutamate secretion
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B0019901molecular_functionprotein kinase binding
B0021510biological_processspinal cord development
B0021772biological_processolfactory bulb development
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030516biological_processregulation of axon extension
B0032991cellular_componentprotein-containing complex
B0042220biological_processresponse to cocaine
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043195cellular_componentterminal bouton
B0043209cellular_componentmyelin sheath
B0045202cellular_componentsynapse
B0045664biological_processregulation of neuron differentiation
B0048489biological_processsynaptic vesicle transport
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098978cellular_componentglutamatergic synapse
B0120025cellular_componentplasma membrane bounded cell projection
B0150052biological_processregulation of postsynapse assembly
C0001975biological_processresponse to amphetamine
C0004157molecular_functiondihydropyrimidinase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0006208biological_processpyrimidine nucleobase catabolic process
C0006897biological_processendocytosis
C0007010biological_processcytoskeleton organization
C0007399biological_processnervous system development
C0009410biological_processresponse to xenobiotic stimulus
C0010975biological_processregulation of neuron projection development
C0014049biological_processpositive regulation of glutamate secretion
C0014069cellular_componentpostsynaptic density
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0019901molecular_functionprotein kinase binding
C0021510biological_processspinal cord development
C0021772biological_processolfactory bulb development
C0030154biological_processcell differentiation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0030516biological_processregulation of axon extension
C0032991cellular_componentprotein-containing complex
C0042220biological_processresponse to cocaine
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043195cellular_componentterminal bouton
C0043209cellular_componentmyelin sheath
C0045202cellular_componentsynapse
C0045664biological_processregulation of neuron differentiation
C0048489biological_processsynaptic vesicle transport
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098978cellular_componentglutamatergic synapse
C0120025cellular_componentplasma membrane bounded cell projection
C0150052biological_processregulation of postsynapse assembly
D0001975biological_processresponse to amphetamine
D0004157molecular_functiondihydropyrimidinase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0006208biological_processpyrimidine nucleobase catabolic process
D0006897biological_processendocytosis
D0007010biological_processcytoskeleton organization
D0007399biological_processnervous system development
D0009410biological_processresponse to xenobiotic stimulus
D0010975biological_processregulation of neuron projection development
D0014049biological_processpositive regulation of glutamate secretion
D0014069cellular_componentpostsynaptic density
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0019901molecular_functionprotein kinase binding
D0021510biological_processspinal cord development
D0021772biological_processolfactory bulb development
D0030154biological_processcell differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0030516biological_processregulation of axon extension
D0032991cellular_componentprotein-containing complex
D0042220biological_processresponse to cocaine
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043195cellular_componentterminal bouton
D0043209cellular_componentmyelin sheath
D0045202cellular_componentsynapse
D0045664biological_processregulation of neuron differentiation
D0048489biological_processsynaptic vesicle transport
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098793cellular_componentpresynapse
D0098978cellular_componentglutamatergic synapse
D0120025cellular_componentplasma membrane bounded cell projection
D0150052biological_processregulation of postsynapse assembly
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Not phosphorylated
ChainResidueDetails
ASER486
BSER486
CSER486
DSER486

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000250|UniProtKB:Q16555
ChainResidueDetails
ATYR32
BTYR32
CTYR32
DTYR32

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O08553
ChainResidueDetails
ALYS258
BLYS258
CLYS258
DLYS258

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER259
ASER540
BSER259
BSER540
CSER259
CSER540
DSER259
DSER540

site_idSWS_FT_FI5
Number of Residues20
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08553
ChainResidueDetails
ASER402
BSER542
CSER402
CSER465
CSER507
CSER537
CSER542
DSER402
DSER465
DSER507
DSER537
ASER465
DSER542
ASER507
ASER537
ASER542
BSER402
BSER465
BSER507
BSER537

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O08553
ChainResidueDetails
ATYR431
ATYR499
BTYR431
BTYR499
CTYR431
CTYR499
DTYR431
DTYR499

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0007744|PubMed:16418269
ChainResidueDetails
ACYS504
BCYS504
CCYS504
DCYS504

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:10757975, ECO:0000269|Ref.6, ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR509
BTHR509
CTHR509
DTHR509

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O08553
ChainResidueDetails
ATHR512
ATHR521
BTHR512
BTHR521
CTHR512
CTHR521
DTHR512
DTHR521

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR514
BTHR514
CTHR514
DTHR514

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16555
ChainResidueDetails
ASER517
BSER517
CSER517
DSER517

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10757975
ChainResidueDetails
ASER518
BSER518
CSER518
DSER518

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine; by DYRK2 => ECO:0000250
ChainResidueDetails
ASER522
BSER522
CSER522
DSER522

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by ROCK2 => ECO:0000250|UniProtKB:O02675
ChainResidueDetails
ATHR555
BTHR555
CTHR555
DTHR555

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Asymmetric dimethylarginine => ECO:0000250|UniProtKB:O08553
ChainResidueDetails
AARG565
BARG565
CARG565
DARG565

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PDB entries from 2025-06-18

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