9C28

Structure of endogenous Glutamine synthetase from rat model of Alzheimer's disease

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL

Chain	Residue	Details
A	PHE62-LEU79

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site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS

Chain	Residue	Details
A	LYS241-SER257

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P15104

Chain	Residue	Details
A	GLU134
B	GLU134
B	GLU136
B	GLU196
B	GLU203
B	HIS253
B	ASN255
B	ARG324
B	TYR336
B	GLU338
C	GLU134
A	GLU136
C	GLU136
C	GLU196
C	GLU203
C	HIS253
C	ASN255
C	ARG324
C	TYR336
C	GLU338
D	GLU134
D	GLU136
A	GLU196
D	GLU196
D	GLU203
D	HIS253
D	ASN255
D	ARG324
D	TYR336
D	GLU338
E	GLU134
E	GLU136
E	GLU196
A	GLU203
E	GLU203
E	HIS253
E	ASN255
E	ARG324
E	TYR336
E	GLU338
F	GLU134
F	GLU136
F	GLU196
F	GLU203
A	HIS253
F	HIS253
F	ASN255
F	ARG324
F	TYR336
F	GLU338
G	GLU134
G	GLU136
G	GLU196
G	GLU203
G	HIS253
A	ASN255
G	ASN255
G	ARG324
G	TYR336
G	GLU338
H	GLU134
H	GLU136
H	GLU196
H	GLU203
H	HIS253
H	ASN255
A	ARG324
H	ARG324
H	TYR336
H	GLU338
I	GLU134
I	GLU136
I	GLU196
I	GLU203
I	HIS253
I	ASN255
I	ARG324
A	TYR336
I	TYR336
I	GLU338
J	GLU134
J	GLU136
J	GLU196
J	GLU203
J	HIS253
J	ASN255
J	ARG324
J	TYR336
A	GLU338
J	GLU338

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P9WN39

Chain	Residue	Details
A	ASN246
D	ASN246
D	ARG319
D	ARG340
E	ASN246
E	ARG319
E	ARG340
F	ASN246
F	ARG319
F	ARG340
G	ASN246
A	ARG319
G	ARG319
G	ARG340
H	ASN246
H	ARG319
H	ARG340
I	ASN246
I	ARG319
I	ARG340
J	ASN246
J	ARG319
A	ARG340
J	ARG340
B	ASN246
B	ARG319
B	ARG340
C	ASN246
C	ARG319
C	ARG340

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P15105

Chain	Residue	Details
A	ALA2
J	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2
I	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P15104

Chain	Residue	Details
A	LYS11
E	LYS14
F	LYS11
F	LYS14
G	LYS11
G	LYS14
H	LYS11
H	LYS14
I	LYS11
I	LYS14
J	LYS11
A	LYS14
J	LYS14
B	LYS11
B	LYS14
C	LYS11
C	LYS14
D	LYS11
D	LYS14
E	LYS11

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P15105

Chain	Residue	Details
A	TYR104
J	TYR104
B	TYR104
C	TYR104
D	TYR104
E	TYR104
F	TYR104
G	TYR104
H	TYR104
I	TYR104

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15104

Chain	Residue	Details
A	SER343
J	SER343
B	SER343
C	SER343
D	SER343
E	SER343
F	SER343
G	SER343
H	SER343
I	SER343

---