Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9C28

Structure of endogenous Glutamine synthetase from rat model of Alzheimer's disease

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006536biological_processglutamate metabolic process
A0006542biological_processglutamine biosynthetic process
A0008283biological_processcell population proliferation
A0009267biological_processcellular response to starvation
A0009749biological_processresponse to glucose
A0010594biological_processregulation of endothelial cell migration
A0016020cellular_componentmembrane
A0016151molecular_functionnickel cation binding
A0016595molecular_functionglutamate binding
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019676biological_processammonia assimilation cycle
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0030145molecular_functionmanganese ion binding
A0032024biological_processpositive regulation of insulin secretion
A0032991cellular_componentprotein-containing complex
A0042254biological_processribosome biogenesis
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043204cellular_componentperikaryon
A0043209cellular_componentmyelin sheath
A0043679cellular_componentaxon terminus
A0044297cellular_componentcell body
A0045503molecular_functiondynein light chain binding
A0045648biological_processpositive regulation of erythrocyte differentiation
A0046872molecular_functionmetal ion binding
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051968biological_processpositive regulation of synaptic transmission, glutamatergic
A0097275biological_processintracellular ammonium homeostasis
A0097386cellular_componentglial cell projection
A1903670biological_processregulation of sprouting angiogenesis
A1904749biological_processregulation of protein localization to nucleolus
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006536biological_processglutamate metabolic process
B0006542biological_processglutamine biosynthetic process
B0008283biological_processcell population proliferation
B0009267biological_processcellular response to starvation
B0009749biological_processresponse to glucose
B0010594biological_processregulation of endothelial cell migration
B0016020cellular_componentmembrane
B0016151molecular_functionnickel cation binding
B0016595molecular_functionglutamate binding
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019676biological_processammonia assimilation cycle
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0030145molecular_functionmanganese ion binding
B0032024biological_processpositive regulation of insulin secretion
B0032991cellular_componentprotein-containing complex
B0042254biological_processribosome biogenesis
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043204cellular_componentperikaryon
B0043209cellular_componentmyelin sheath
B0043679cellular_componentaxon terminus
B0044297cellular_componentcell body
B0045503molecular_functiondynein light chain binding
B0045648biological_processpositive regulation of erythrocyte differentiation
B0046872molecular_functionmetal ion binding
B0050679biological_processpositive regulation of epithelial cell proliferation
B0051968biological_processpositive regulation of synaptic transmission, glutamatergic
B0097275biological_processintracellular ammonium homeostasis
B0097386cellular_componentglial cell projection
B1903670biological_processregulation of sprouting angiogenesis
B1904749biological_processregulation of protein localization to nucleolus
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001525biological_processangiogenesis
C0003824molecular_functioncatalytic activity
C0004356molecular_functionglutamine synthetase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006536biological_processglutamate metabolic process
C0006542biological_processglutamine biosynthetic process
C0008283biological_processcell population proliferation
C0009267biological_processcellular response to starvation
C0009749biological_processresponse to glucose
C0010594biological_processregulation of endothelial cell migration
C0016020cellular_componentmembrane
C0016151molecular_functionnickel cation binding
C0016595molecular_functionglutamate binding
C0016740molecular_functiontransferase activity
C0016874molecular_functionligase activity
C0018345biological_processprotein palmitoylation
C0019676biological_processammonia assimilation cycle
C0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
C0030145molecular_functionmanganese ion binding
C0032024biological_processpositive regulation of insulin secretion
C0032991cellular_componentprotein-containing complex
C0042254biological_processribosome biogenesis
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043204cellular_componentperikaryon
C0043209cellular_componentmyelin sheath
C0043679cellular_componentaxon terminus
C0044297cellular_componentcell body
C0045503molecular_functiondynein light chain binding
C0045648biological_processpositive regulation of erythrocyte differentiation
C0046872molecular_functionmetal ion binding
C0050679biological_processpositive regulation of epithelial cell proliferation
C0051968biological_processpositive regulation of synaptic transmission, glutamatergic
C0097275biological_processintracellular ammonium homeostasis
C0097386cellular_componentglial cell projection
C1903670biological_processregulation of sprouting angiogenesis
C1904749biological_processregulation of protein localization to nucleolus
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006536biological_processglutamate metabolic process
D0006542biological_processglutamine biosynthetic process
D0008283biological_processcell population proliferation
D0009267biological_processcellular response to starvation
D0009749biological_processresponse to glucose
D0010594biological_processregulation of endothelial cell migration
D0016020cellular_componentmembrane
D0016151molecular_functionnickel cation binding
D0016595molecular_functionglutamate binding
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019676biological_processammonia assimilation cycle
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0030145molecular_functionmanganese ion binding
D0032024biological_processpositive regulation of insulin secretion
D0032991cellular_componentprotein-containing complex
D0042254biological_processribosome biogenesis
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043204cellular_componentperikaryon
D0043209cellular_componentmyelin sheath
D0043679cellular_componentaxon terminus
D0044297cellular_componentcell body
D0045503molecular_functiondynein light chain binding
D0045648biological_processpositive regulation of erythrocyte differentiation
D0046872molecular_functionmetal ion binding
D0050679biological_processpositive regulation of epithelial cell proliferation
D0051968biological_processpositive regulation of synaptic transmission, glutamatergic
D0097275biological_processintracellular ammonium homeostasis
D0097386cellular_componentglial cell projection
D1903670biological_processregulation of sprouting angiogenesis
D1904749biological_processregulation of protein localization to nucleolus
E0000166molecular_functionnucleotide binding
E0000287molecular_functionmagnesium ion binding
E0001525biological_processangiogenesis
E0003824molecular_functioncatalytic activity
E0004356molecular_functionglutamine synthetase activity
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006536biological_processglutamate metabolic process
E0006542biological_processglutamine biosynthetic process
E0008283biological_processcell population proliferation
E0009267biological_processcellular response to starvation
E0009749biological_processresponse to glucose
E0010594biological_processregulation of endothelial cell migration
E0016020cellular_componentmembrane
E0016151molecular_functionnickel cation binding
E0016595molecular_functionglutamate binding
E0016740molecular_functiontransferase activity
E0016874molecular_functionligase activity
E0018345biological_processprotein palmitoylation
E0019676biological_processammonia assimilation cycle
E0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
E0030145molecular_functionmanganese ion binding
E0032024biological_processpositive regulation of insulin secretion
E0032991cellular_componentprotein-containing complex
E0042254biological_processribosome biogenesis
E0042802molecular_functionidentical protein binding
E0042995cellular_componentcell projection
E0043204cellular_componentperikaryon
E0043209cellular_componentmyelin sheath
E0043679cellular_componentaxon terminus
E0044297cellular_componentcell body
E0045503molecular_functiondynein light chain binding
E0045648biological_processpositive regulation of erythrocyte differentiation
E0046872molecular_functionmetal ion binding
E0050679biological_processpositive regulation of epithelial cell proliferation
E0051968biological_processpositive regulation of synaptic transmission, glutamatergic
E0097275biological_processintracellular ammonium homeostasis
E0097386cellular_componentglial cell projection
E1903670biological_processregulation of sprouting angiogenesis
E1904749biological_processregulation of protein localization to nucleolus
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001525biological_processangiogenesis
F0003824molecular_functioncatalytic activity
F0004356molecular_functionglutamine synthetase activity
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006536biological_processglutamate metabolic process
F0006542biological_processglutamine biosynthetic process
F0008283biological_processcell population proliferation
F0009267biological_processcellular response to starvation
F0009749biological_processresponse to glucose
F0010594biological_processregulation of endothelial cell migration
F0016020cellular_componentmembrane
F0016151molecular_functionnickel cation binding
F0016595molecular_functionglutamate binding
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0018345biological_processprotein palmitoylation
F0019676biological_processammonia assimilation cycle
F0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
F0030145molecular_functionmanganese ion binding
F0032024biological_processpositive regulation of insulin secretion
F0032991cellular_componentprotein-containing complex
F0042254biological_processribosome biogenesis
F0042802molecular_functionidentical protein binding
F0042995cellular_componentcell projection
F0043204cellular_componentperikaryon
F0043209cellular_componentmyelin sheath
F0043679cellular_componentaxon terminus
F0044297cellular_componentcell body
F0045503molecular_functiondynein light chain binding
F0045648biological_processpositive regulation of erythrocyte differentiation
F0046872molecular_functionmetal ion binding
F0050679biological_processpositive regulation of epithelial cell proliferation
F0051968biological_processpositive regulation of synaptic transmission, glutamatergic
F0097275biological_processintracellular ammonium homeostasis
F0097386cellular_componentglial cell projection
F1903670biological_processregulation of sprouting angiogenesis
F1904749biological_processregulation of protein localization to nucleolus
G0000166molecular_functionnucleotide binding
G0000287molecular_functionmagnesium ion binding
G0001525biological_processangiogenesis
G0003824molecular_functioncatalytic activity
G0004356molecular_functionglutamine synthetase activity
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005783cellular_componentendoplasmic reticulum
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006536biological_processglutamate metabolic process
G0006542biological_processglutamine biosynthetic process
G0008283biological_processcell population proliferation
G0009267biological_processcellular response to starvation
G0009749biological_processresponse to glucose
G0010594biological_processregulation of endothelial cell migration
G0016020cellular_componentmembrane
G0016151molecular_functionnickel cation binding
G0016595molecular_functionglutamate binding
G0016740molecular_functiontransferase activity
G0016874molecular_functionligase activity
G0018345biological_processprotein palmitoylation
G0019676biological_processammonia assimilation cycle
G0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
G0030145molecular_functionmanganese ion binding
G0032024biological_processpositive regulation of insulin secretion
G0032991cellular_componentprotein-containing complex
G0042254biological_processribosome biogenesis
G0042802molecular_functionidentical protein binding
G0042995cellular_componentcell projection
G0043204cellular_componentperikaryon
G0043209cellular_componentmyelin sheath
G0043679cellular_componentaxon terminus
G0044297cellular_componentcell body
G0045503molecular_functiondynein light chain binding
G0045648biological_processpositive regulation of erythrocyte differentiation
G0046872molecular_functionmetal ion binding
G0050679biological_processpositive regulation of epithelial cell proliferation
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0097275biological_processintracellular ammonium homeostasis
G0097386cellular_componentglial cell projection
G1903670biological_processregulation of sprouting angiogenesis
G1904749biological_processregulation of protein localization to nucleolus
H0000166molecular_functionnucleotide binding
H0000287molecular_functionmagnesium ion binding
H0001525biological_processangiogenesis
H0003824molecular_functioncatalytic activity
H0004356molecular_functionglutamine synthetase activity
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005783cellular_componentendoplasmic reticulum
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006536biological_processglutamate metabolic process
H0006542biological_processglutamine biosynthetic process
H0008283biological_processcell population proliferation
H0009267biological_processcellular response to starvation
H0009749biological_processresponse to glucose
H0010594biological_processregulation of endothelial cell migration
H0016020cellular_componentmembrane
H0016151molecular_functionnickel cation binding
H0016595molecular_functionglutamate binding
H0016740molecular_functiontransferase activity
H0016874molecular_functionligase activity
H0018345biological_processprotein palmitoylation
H0019676biological_processammonia assimilation cycle
H0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
H0030145molecular_functionmanganese ion binding
H0032024biological_processpositive regulation of insulin secretion
H0032991cellular_componentprotein-containing complex
H0042254biological_processribosome biogenesis
H0042802molecular_functionidentical protein binding
H0042995cellular_componentcell projection
H0043204cellular_componentperikaryon
H0043209cellular_componentmyelin sheath
H0043679cellular_componentaxon terminus
H0044297cellular_componentcell body
H0045503molecular_functiondynein light chain binding
H0045648biological_processpositive regulation of erythrocyte differentiation
H0046872molecular_functionmetal ion binding
H0050679biological_processpositive regulation of epithelial cell proliferation
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0097275biological_processintracellular ammonium homeostasis
H0097386cellular_componentglial cell projection
H1903670biological_processregulation of sprouting angiogenesis
H1904749biological_processregulation of protein localization to nucleolus
I0000166molecular_functionnucleotide binding
I0000287molecular_functionmagnesium ion binding
I0001525biological_processangiogenesis
I0003824molecular_functioncatalytic activity
I0004356molecular_functionglutamine synthetase activity
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005783cellular_componentendoplasmic reticulum
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006536biological_processglutamate metabolic process
I0006542biological_processglutamine biosynthetic process
I0008283biological_processcell population proliferation
I0009267biological_processcellular response to starvation
I0009749biological_processresponse to glucose
I0010594biological_processregulation of endothelial cell migration
I0016020cellular_componentmembrane
I0016151molecular_functionnickel cation binding
I0016595molecular_functionglutamate binding
I0016740molecular_functiontransferase activity
I0016874molecular_functionligase activity
I0018345biological_processprotein palmitoylation
I0019676biological_processammonia assimilation cycle
I0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
I0030145molecular_functionmanganese ion binding
I0032024biological_processpositive regulation of insulin secretion
I0032991cellular_componentprotein-containing complex
I0042254biological_processribosome biogenesis
I0042802molecular_functionidentical protein binding
I0042995cellular_componentcell projection
I0043204cellular_componentperikaryon
I0043209cellular_componentmyelin sheath
I0043679cellular_componentaxon terminus
I0044297cellular_componentcell body
I0045503molecular_functiondynein light chain binding
I0045648biological_processpositive regulation of erythrocyte differentiation
I0046872molecular_functionmetal ion binding
I0050679biological_processpositive regulation of epithelial cell proliferation
I0051968biological_processpositive regulation of synaptic transmission, glutamatergic
I0097275biological_processintracellular ammonium homeostasis
I0097386cellular_componentglial cell projection
I1903670biological_processregulation of sprouting angiogenesis
I1904749biological_processregulation of protein localization to nucleolus
J0000166molecular_functionnucleotide binding
J0000287molecular_functionmagnesium ion binding
J0001525biological_processangiogenesis
J0003824molecular_functioncatalytic activity
J0004356molecular_functionglutamine synthetase activity
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005783cellular_componentendoplasmic reticulum
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006536biological_processglutamate metabolic process
J0006542biological_processglutamine biosynthetic process
J0008283biological_processcell population proliferation
J0009267biological_processcellular response to starvation
J0009749biological_processresponse to glucose
J0010594biological_processregulation of endothelial cell migration
J0016020cellular_componentmembrane
J0016151molecular_functionnickel cation binding
J0016595molecular_functionglutamate binding
J0016740molecular_functiontransferase activity
J0016874molecular_functionligase activity
J0018345biological_processprotein palmitoylation
J0019676biological_processammonia assimilation cycle
J0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
J0030145molecular_functionmanganese ion binding
J0032024biological_processpositive regulation of insulin secretion
J0032991cellular_componentprotein-containing complex
J0042254biological_processribosome biogenesis
J0042802molecular_functionidentical protein binding
J0042995cellular_componentcell projection
J0043204cellular_componentperikaryon
J0043209cellular_componentmyelin sheath
J0043679cellular_componentaxon terminus
J0044297cellular_componentcell body
J0045503molecular_functiondynein light chain binding
J0045648biological_processpositive regulation of erythrocyte differentiation
J0046872molecular_functionmetal ion binding
J0050679biological_processpositive regulation of epithelial cell proliferation
J0051968biological_processpositive regulation of synaptic transmission, glutamatergic
J0097275biological_processintracellular ammonium homeostasis
J0097386cellular_componentglial cell projection
J1903670biological_processregulation of sprouting angiogenesis
J1904749biological_processregulation of protein localization to nucleolus
Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues820
DetailsDomain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues230
DetailsRegion: {"description":"Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues160
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues10
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues20
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues10
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon