9C28

Structure of endogenous Glutamine synthetase from rat model of Alzheimer's disease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001525	biological_process	angiogenesis
A	0003824	molecular_function	catalytic activity
A	0004356	molecular_function	glutamine synthetase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006536	biological_process	glutamate metabolic process
A	0006542	biological_process	glutamine biosynthetic process
A	0008283	biological_process	cell population proliferation
A	0009267	biological_process	cellular response to starvation
A	0009749	biological_process	response to glucose
A	0010594	biological_process	regulation of endothelial cell migration
A	0016151	molecular_function	nickel cation binding
A	0016595	molecular_function	glutamate binding
A	0016740	molecular_function	transferase activity
A	0016874	molecular_function	ligase activity
A	0018345	biological_process	protein palmitoylation
A	0019676	biological_process	ammonia assimilation cycle
A	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
A	0030145	molecular_function	manganese ion binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0032991	cellular_component	protein-containing complex
A	0042254	biological_process	ribosome biogenesis
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0043204	cellular_component	perikaryon
A	0043209	cellular_component	myelin sheath
A	0043679	cellular_component	axon terminus
A	0044297	cellular_component	cell body
A	0045503	molecular_function	dynein light chain binding
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0046872	molecular_function	metal ion binding
A	0050679	biological_process	positive regulation of epithelial cell proliferation
A	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
A	0097275	biological_process	intracellular ammonium homeostasis
A	0097386	cellular_component	glial cell projection
A	1903670	biological_process	regulation of sprouting angiogenesis
A	1904749	biological_process	regulation of protein localization to nucleolus
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001525	biological_process	angiogenesis
B	0003824	molecular_function	catalytic activity
B	0004356	molecular_function	glutamine synthetase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006536	biological_process	glutamate metabolic process
B	0006542	biological_process	glutamine biosynthetic process
B	0008283	biological_process	cell population proliferation
B	0009267	biological_process	cellular response to starvation
B	0009749	biological_process	response to glucose
B	0010594	biological_process	regulation of endothelial cell migration
B	0016151	molecular_function	nickel cation binding
B	0016595	molecular_function	glutamate binding
B	0016740	molecular_function	transferase activity
B	0016874	molecular_function	ligase activity
B	0018345	biological_process	protein palmitoylation
B	0019676	biological_process	ammonia assimilation cycle
B	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
B	0030145	molecular_function	manganese ion binding
B	0032024	biological_process	positive regulation of insulin secretion
B	0032991	cellular_component	protein-containing complex
B	0042254	biological_process	ribosome biogenesis
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043204	cellular_component	perikaryon
B	0043209	cellular_component	myelin sheath
B	0043679	cellular_component	axon terminus
B	0044297	cellular_component	cell body
B	0045503	molecular_function	dynein light chain binding
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0046872	molecular_function	metal ion binding
B	0050679	biological_process	positive regulation of epithelial cell proliferation
B	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
B	0097275	biological_process	intracellular ammonium homeostasis
B	0097386	cellular_component	glial cell projection
B	1903670	biological_process	regulation of sprouting angiogenesis
B	1904749	biological_process	regulation of protein localization to nucleolus
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001525	biological_process	angiogenesis
C	0003824	molecular_function	catalytic activity
C	0004356	molecular_function	glutamine synthetase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006536	biological_process	glutamate metabolic process
C	0006542	biological_process	glutamine biosynthetic process
C	0008283	biological_process	cell population proliferation
C	0009267	biological_process	cellular response to starvation
C	0009749	biological_process	response to glucose
C	0010594	biological_process	regulation of endothelial cell migration
C	0016151	molecular_function	nickel cation binding
C	0016595	molecular_function	glutamate binding
C	0016740	molecular_function	transferase activity
C	0016874	molecular_function	ligase activity
C	0018345	biological_process	protein palmitoylation
C	0019676	biological_process	ammonia assimilation cycle
C	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
C	0030145	molecular_function	manganese ion binding
C	0032024	biological_process	positive regulation of insulin secretion
C	0032991	cellular_component	protein-containing complex
C	0042254	biological_process	ribosome biogenesis
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043204	cellular_component	perikaryon
C	0043209	cellular_component	myelin sheath
C	0043679	cellular_component	axon terminus
C	0044297	cellular_component	cell body
C	0045503	molecular_function	dynein light chain binding
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0046872	molecular_function	metal ion binding
C	0050679	biological_process	positive regulation of epithelial cell proliferation
C	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
C	0097275	biological_process	intracellular ammonium homeostasis
C	0097386	cellular_component	glial cell projection
C	1903670	biological_process	regulation of sprouting angiogenesis
C	1904749	biological_process	regulation of protein localization to nucleolus
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001525	biological_process	angiogenesis
D	0003824	molecular_function	catalytic activity
D	0004356	molecular_function	glutamine synthetase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006536	biological_process	glutamate metabolic process
D	0006542	biological_process	glutamine biosynthetic process
D	0008283	biological_process	cell population proliferation
D	0009267	biological_process	cellular response to starvation
D	0009749	biological_process	response to glucose
D	0010594	biological_process	regulation of endothelial cell migration
D	0016151	molecular_function	nickel cation binding
D	0016595	molecular_function	glutamate binding
D	0016740	molecular_function	transferase activity
D	0016874	molecular_function	ligase activity
D	0018345	biological_process	protein palmitoylation
D	0019676	biological_process	ammonia assimilation cycle
D	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
D	0030145	molecular_function	manganese ion binding
D	0032024	biological_process	positive regulation of insulin secretion
D	0032991	cellular_component	protein-containing complex
D	0042254	biological_process	ribosome biogenesis
D	0042802	molecular_function	identical protein binding
D	0042995	cellular_component	cell projection
D	0043204	cellular_component	perikaryon
D	0043209	cellular_component	myelin sheath
D	0043679	cellular_component	axon terminus
D	0044297	cellular_component	cell body
D	0045503	molecular_function	dynein light chain binding
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0046872	molecular_function	metal ion binding
D	0050679	biological_process	positive regulation of epithelial cell proliferation
D	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
D	0097275	biological_process	intracellular ammonium homeostasis
D	0097386	cellular_component	glial cell projection
D	1903670	biological_process	regulation of sprouting angiogenesis
D	1904749	biological_process	regulation of protein localization to nucleolus
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001525	biological_process	angiogenesis
E	0003824	molecular_function	catalytic activity
E	0004356	molecular_function	glutamine synthetase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006536	biological_process	glutamate metabolic process
E	0006542	biological_process	glutamine biosynthetic process
E	0008283	biological_process	cell population proliferation
E	0009267	biological_process	cellular response to starvation
E	0009749	biological_process	response to glucose
E	0010594	biological_process	regulation of endothelial cell migration
E	0016151	molecular_function	nickel cation binding
E	0016595	molecular_function	glutamate binding
E	0016740	molecular_function	transferase activity
E	0016874	molecular_function	ligase activity
E	0018345	biological_process	protein palmitoylation
E	0019676	biological_process	ammonia assimilation cycle
E	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
E	0030145	molecular_function	manganese ion binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0032991	cellular_component	protein-containing complex
E	0042254	biological_process	ribosome biogenesis
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0043204	cellular_component	perikaryon
E	0043209	cellular_component	myelin sheath
E	0043679	cellular_component	axon terminus
E	0044297	cellular_component	cell body
E	0045503	molecular_function	dynein light chain binding
E	0045648	biological_process	positive regulation of erythrocyte differentiation
E	0046872	molecular_function	metal ion binding
E	0050679	biological_process	positive regulation of epithelial cell proliferation
E	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
E	0097275	biological_process	intracellular ammonium homeostasis
E	0097386	cellular_component	glial cell projection
E	1903670	biological_process	regulation of sprouting angiogenesis
E	1904749	biological_process	regulation of protein localization to nucleolus
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001525	biological_process	angiogenesis
F	0003824	molecular_function	catalytic activity
F	0004356	molecular_function	glutamine synthetase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006536	biological_process	glutamate metabolic process
F	0006542	biological_process	glutamine biosynthetic process
F	0008283	biological_process	cell population proliferation
F	0009267	biological_process	cellular response to starvation
F	0009749	biological_process	response to glucose
F	0010594	biological_process	regulation of endothelial cell migration
F	0016151	molecular_function	nickel cation binding
F	0016595	molecular_function	glutamate binding
F	0016740	molecular_function	transferase activity
F	0016874	molecular_function	ligase activity
F	0018345	biological_process	protein palmitoylation
F	0019676	biological_process	ammonia assimilation cycle
F	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
F	0030145	molecular_function	manganese ion binding
F	0032024	biological_process	positive regulation of insulin secretion
F	0032991	cellular_component	protein-containing complex
F	0042254	biological_process	ribosome biogenesis
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0043204	cellular_component	perikaryon
F	0043209	cellular_component	myelin sheath
F	0043679	cellular_component	axon terminus
F	0044297	cellular_component	cell body
F	0045503	molecular_function	dynein light chain binding
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0046872	molecular_function	metal ion binding
F	0050679	biological_process	positive regulation of epithelial cell proliferation
F	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
F	0097275	biological_process	intracellular ammonium homeostasis
F	0097386	cellular_component	glial cell projection
F	1903670	biological_process	regulation of sprouting angiogenesis
F	1904749	biological_process	regulation of protein localization to nucleolus
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0001525	biological_process	angiogenesis
G	0003824	molecular_function	catalytic activity
G	0004356	molecular_function	glutamine synthetase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006536	biological_process	glutamate metabolic process
G	0006542	biological_process	glutamine biosynthetic process
G	0008283	biological_process	cell population proliferation
G	0009267	biological_process	cellular response to starvation
G	0009749	biological_process	response to glucose
G	0010594	biological_process	regulation of endothelial cell migration
G	0016151	molecular_function	nickel cation binding
G	0016595	molecular_function	glutamate binding
G	0016740	molecular_function	transferase activity
G	0016874	molecular_function	ligase activity
G	0018345	biological_process	protein palmitoylation
G	0019676	biological_process	ammonia assimilation cycle
G	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
G	0030145	molecular_function	manganese ion binding
G	0032024	biological_process	positive regulation of insulin secretion
G	0032991	cellular_component	protein-containing complex
G	0042254	biological_process	ribosome biogenesis
G	0042802	molecular_function	identical protein binding
G	0042995	cellular_component	cell projection
G	0043204	cellular_component	perikaryon
G	0043209	cellular_component	myelin sheath
G	0043679	cellular_component	axon terminus
G	0044297	cellular_component	cell body
G	0045503	molecular_function	dynein light chain binding
G	0045648	biological_process	positive regulation of erythrocyte differentiation
G	0046872	molecular_function	metal ion binding
G	0050679	biological_process	positive regulation of epithelial cell proliferation
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0097275	biological_process	intracellular ammonium homeostasis
G	0097386	cellular_component	glial cell projection
G	1903670	biological_process	regulation of sprouting angiogenesis
G	1904749	biological_process	regulation of protein localization to nucleolus
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0001525	biological_process	angiogenesis
H	0003824	molecular_function	catalytic activity
H	0004356	molecular_function	glutamine synthetase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006536	biological_process	glutamate metabolic process
H	0006542	biological_process	glutamine biosynthetic process
H	0008283	biological_process	cell population proliferation
H	0009267	biological_process	cellular response to starvation
H	0009749	biological_process	response to glucose
H	0010594	biological_process	regulation of endothelial cell migration
H	0016151	molecular_function	nickel cation binding
H	0016595	molecular_function	glutamate binding
H	0016740	molecular_function	transferase activity
H	0016874	molecular_function	ligase activity
H	0018345	biological_process	protein palmitoylation
H	0019676	biological_process	ammonia assimilation cycle
H	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
H	0030145	molecular_function	manganese ion binding
H	0032024	biological_process	positive regulation of insulin secretion
H	0032991	cellular_component	protein-containing complex
H	0042254	biological_process	ribosome biogenesis
H	0042802	molecular_function	identical protein binding
H	0042995	cellular_component	cell projection
H	0043204	cellular_component	perikaryon
H	0043209	cellular_component	myelin sheath
H	0043679	cellular_component	axon terminus
H	0044297	cellular_component	cell body
H	0045503	molecular_function	dynein light chain binding
H	0045648	biological_process	positive regulation of erythrocyte differentiation
H	0046872	molecular_function	metal ion binding
H	0050679	biological_process	positive regulation of epithelial cell proliferation
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0097275	biological_process	intracellular ammonium homeostasis
H	0097386	cellular_component	glial cell projection
H	1903670	biological_process	regulation of sprouting angiogenesis
H	1904749	biological_process	regulation of protein localization to nucleolus
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0001525	biological_process	angiogenesis
I	0003824	molecular_function	catalytic activity
I	0004356	molecular_function	glutamine synthetase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006536	biological_process	glutamate metabolic process
I	0006542	biological_process	glutamine biosynthetic process
I	0008283	biological_process	cell population proliferation
I	0009267	biological_process	cellular response to starvation
I	0009749	biological_process	response to glucose
I	0010594	biological_process	regulation of endothelial cell migration
I	0016151	molecular_function	nickel cation binding
I	0016595	molecular_function	glutamate binding
I	0016740	molecular_function	transferase activity
I	0016874	molecular_function	ligase activity
I	0018345	biological_process	protein palmitoylation
I	0019676	biological_process	ammonia assimilation cycle
I	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
I	0030145	molecular_function	manganese ion binding
I	0032024	biological_process	positive regulation of insulin secretion
I	0032991	cellular_component	protein-containing complex
I	0042254	biological_process	ribosome biogenesis
I	0042802	molecular_function	identical protein binding
I	0042995	cellular_component	cell projection
I	0043204	cellular_component	perikaryon
I	0043209	cellular_component	myelin sheath
I	0043679	cellular_component	axon terminus
I	0044297	cellular_component	cell body
I	0045503	molecular_function	dynein light chain binding
I	0045648	biological_process	positive regulation of erythrocyte differentiation
I	0046872	molecular_function	metal ion binding
I	0050679	biological_process	positive regulation of epithelial cell proliferation
I	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
I	0097275	biological_process	intracellular ammonium homeostasis
I	0097386	cellular_component	glial cell projection
I	1903670	biological_process	regulation of sprouting angiogenesis
I	1904749	biological_process	regulation of protein localization to nucleolus
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0001525	biological_process	angiogenesis
J	0003824	molecular_function	catalytic activity
J	0004356	molecular_function	glutamine synthetase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006536	biological_process	glutamate metabolic process
J	0006542	biological_process	glutamine biosynthetic process
J	0008283	biological_process	cell population proliferation
J	0009267	biological_process	cellular response to starvation
J	0009749	biological_process	response to glucose
J	0010594	biological_process	regulation of endothelial cell migration
J	0016151	molecular_function	nickel cation binding
J	0016595	molecular_function	glutamate binding
J	0016740	molecular_function	transferase activity
J	0016874	molecular_function	ligase activity
J	0018345	biological_process	protein palmitoylation
J	0019676	biological_process	ammonia assimilation cycle
J	0019706	molecular_function	protein-cysteine S-palmitoyltransferase activity
J	0030145	molecular_function	manganese ion binding
J	0032024	biological_process	positive regulation of insulin secretion
J	0032991	cellular_component	protein-containing complex
J	0042254	biological_process	ribosome biogenesis
J	0042802	molecular_function	identical protein binding
J	0042995	cellular_component	cell projection
J	0043204	cellular_component	perikaryon
J	0043209	cellular_component	myelin sheath
J	0043679	cellular_component	axon terminus
J	0044297	cellular_component	cell body
J	0045503	molecular_function	dynein light chain binding
J	0045648	biological_process	positive regulation of erythrocyte differentiation
J	0046872	molecular_function	metal ion binding
J	0050679	biological_process	positive regulation of epithelial cell proliferation
J	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
J	0097275	biological_process	intracellular ammonium homeostasis
J	0097386	cellular_component	glial cell projection
J	1903670	biological_process	regulation of sprouting angiogenesis
J	1904749	biological_process	regulation of protein localization to nucleolus

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	18
Details	GLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL

Chain	Residue	Details
A	PHE62-LEU79

---

site_id	PS00181
Number of Residues	17
Details	GLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS

Chain	Residue	Details
A	LYS241-SER257

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	820
Details	Domain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	230
Details	Region: {"description":"Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	160
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---