9BWC

Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0016020	cellular_component	membrane
A	0016594	molecular_function	glycine binding
A	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
A	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0016020	cellular_component	membrane
B	0016594	molecular_function	glycine binding
B	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
B	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0016020	cellular_component	membrane
C	0016594	molecular_function	glycine binding
C	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
C	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0016020	cellular_component	membrane
D	0016594	molecular_function	glycine binding
D	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
D	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006821	biological_process	chloride transport
E	0016020	cellular_component	membrane
E	0016594	molecular_function	glycine binding
E	0016934	molecular_function	extracellularly glycine-gated chloride channel activity
E	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC

Chain	Residue	Details
A	CYS138-CYS152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1215
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	ALA1-TYR222
D	ALA1-TYR222
D	ARG271-LYS281
D	LYS419-ASP431
E	ALA1-TYR222
E	ARG271-LYS281
E	LYS419-ASP431
A	ARG271-LYS281
A	LYS419-ASP431
B	ALA1-TYR222
B	ARG271-LYS281
B	LYS419-ASP431
C	ALA1-TYR222
C	ARG271-LYS281
C	LYS419-ASP431

---

site_id	SWS_FT_FI2
Number of Residues	105
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	TYR223-ILE244
B	TYR223-ILE244
C	TYR223-ILE244
D	TYR223-ILE244
E	TYR223-ILE244

---

site_id	SWS_FT_FI3
Number of Residues	490
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	ASN245-ALA249
E	ALA303-THR397
A	ALA303-THR397
B	ASN245-ALA249
B	ALA303-THR397
C	ASN245-ALA249
C	ALA303-THR397
D	ASN245-ALA249
D	ALA303-THR397
E	ASN245-ALA249

---

site_id	SWS_FT_FI4
Number of Residues	100
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	PRO250-SER270
B	PRO250-SER270
C	PRO250-SER270
D	PRO250-SER270
E	PRO250-SER270

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	ALA282-ALA302
B	ALA282-ALA302
C	ALA282-ALA302
D	ALA282-ALA302
E	ALA282-ALA302

---

site_id	SWS_FT_FI6
Number of Residues	100
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	ILE398-TYR418
B	ILE398-TYR418
C	ILE398-TYR418
D	ILE398-TYR418
E	ILE398-TYR418

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P23415

Chain	Residue	Details
A	GLU192
D	GLU192
D	ASP194
D	HIS215
E	GLU192
E	ASP194
E	HIS215
A	ASP194
A	HIS215
B	GLU192
B	ASP194
B	HIS215
C	GLU192
C	ASP194
C	HIS215

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	TYR202
B	TYR202
C	TYR202
D	TYR202
E	TYR202

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26416729

Chain	Residue	Details
A	LEU261
B	LEU261
C	LEU261
D	LEU261
E	LEU261

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91XP5

Chain	Residue	Details
A	SER337
E	SER346
A	SER346
B	SER337
B	SER346
C	SER337
C	SER346
D	SER337
D	SER346
E	SER337

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26416729, ECO:0007744|PDB:5CFB

Chain	Residue	Details
A	ASN38
B	ASN38
C	ASN38
D	ASN38
E	ASN38

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