9BVQ
Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008488 | molecular_function | gamma-glutamyl carboxylase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019842 | molecular_function | vitamin binding |
| A | 0036211 | biological_process | protein modification process |
| A | 0042373 | biological_process | vitamin K metabolic process |
| A | 0046929 | biological_process | negative regulation of neurotransmitter secretion |
| A | 0051604 | biological_process | protein maturation |
| A | 1903011 | biological_process | negative regulation of bone development |
| A | 2000225 | biological_process | negative regulation of testosterone biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00011 |
| Number of Residues | 26 |
| Details | GLA_1 Vitamin K-dependent carboxylation domain. EclEErCsweearEyfedntlter.FW |
| Chain | Residue | Details |
| P | GLU66-TRP91 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| P | ALA50-SER109 | |
| A | TRP114-CYS134 | |
| A | ILE137-TRP157 | |
| A | LEU293-PRO313 | |
| A | LEU362-PHE382 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| P | LEU110-TRP130 | |
| A | ASN158-GLN292 | |
| A | LEU383-PHE758 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-carboxyglutamate => ECO:0000255|PROSITE-ProRule:PRU00463 |
| Chain | Residue | Details |
| P | GLU70 | |
| A | GLU314-GLN361 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:17073445 |
| Chain | Residue | Details |
| A | LYS218 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN459 | |
| A | ASN550 |
