9BUK
Outward-facing, ATP-bound Multidrug Resistance-associated Protein 2 (MRP2) (E1462Q)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009986 | cellular_component | cell surface |
| A | 0010629 | biological_process | negative regulation of gene expression |
| A | 0015127 | molecular_function | bilirubin transmembrane transporter activity |
| A | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015723 | biological_process | bilirubin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0043225 | molecular_function | ATPase-coupled inorganic anion transmembrane transporter activity |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0046618 | biological_process | xenobiotic export from cell |
| A | 0046942 | biological_process | carboxylic acid transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0071716 | biological_process | leukotriene transport |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRISLARAT |
| Chain | Residue | Details |
| A | LEU761-THR775 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-PHE27 | |
| A | ASP90-GLN93 | |
| A | GLN148-SER165 | |
| A | PHE335-GLY360 | |
| A | LEU459-PRO461 | |
| A | VAL566-ASN587 | |
| A | PHE993-ALA1033 | |
| A | ALA1119 | |
| A | LEU1233-SER1234 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLU28-LEU48 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1035 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU49-LYS68 | |
| A | LEU115-GLN126 | |
| A | ASN187-ALA313 | |
| A | PHE382-PHE437 | |
| A | LYS483-CYS544 | |
| A | SER609-LEU971 | |
| A | ILE1055-GLN1097 | |
| A | TYR1141-LEU1211 | |
| A | VAL1256-PHE1545 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN69-GLU89 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ALA94-VAL114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LYS127-PHE147 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | CYS166-GLU186 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LEU314-ILE334 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TYR361-TYR381 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | MET438-GLU458 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER462-THR482 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | VAL545-TYR565 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ILE588-VAL608 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN972-ALA992 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN1034-ASN1054 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER1098-MET1118 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | THR1120-PHE1140 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLU1212-THR1232 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLY1235-LEU1255 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY671 | |
| A | GLY1334 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63120 |
| Chain | Residue | Details |
| A | SER281 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER283 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER878 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER926 | |
| A | SER930 | |
| A | SER938 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER1438 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN7 | |
| A | ASN12 | |
| A | ASN1011 |
