9BUB
Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00258 |
| Number of Residues | 15 |
| Details | CALCITONIN Calcitonin / CGRP / IAPP family signature. CNT.ATCAtqrLaefL |
| Chain | Residue | Details |
| P | CYS2-LEU16 |
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWddTpagvlsyqfCP |
| Chain | Residue | Details |
| R | CYS72-PRO96 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFVaTIYCFcNneV |
| Chain | Residue | Details |
| R | GLN383-VAL398 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| G | ALA2 | |
| A | ASN54 | |
| A | LEU197 | |
| A | THR204 | |
| A | ASP223 | |
| A | ASN292 | |
| A | SER366 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| G | CYS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212 |
| Chain | Residue | Details |
| G | CYS68 | |
| R | TYR243-LEU259 | |
| R | ARG321-LYS340 | |
| R | ASN395-ALA474 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl glycine => ECO:0000250|UniProtKB:P04896 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21044946 |
| Chain | Residue | Details |
| A | CYS3 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | LYS300 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX |
| Chain | Residue | Details |
| R | LEU297-VAL320 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX |
| Chain | Residue | Details |
| R | ALA341-PHE359 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35324283, ECO:0007744|PDB:7TYX |
| Chain | Residue | Details |
| R | LEU368-CYS394 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN28 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32035902, ECO:0007744|PDB:6PGQ |
| Chain | Residue | Details |
| R | ASN73 | |
| R | ASN125 | |
| R | ASN130 |
