9BU4

Crystal structure of an MKP5 mutant, Y435W, in complex with an allosteric inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
A	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
B	0006470	biological_process	protein dephosphorylation
B	0016311	biological_process	dephosphorylation
B	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
C	0006470	biological_process	protein dephosphorylation
C	0016311	biological_process	dephosphorylation
C	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
D	0006470	biological_process	protein dephosphorylation
D	0016311	biological_process	dephosphorylation
D	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
E	0006470	biological_process	protein dephosphorylation
E	0016311	biological_process	dephosphorylation
E	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
F	0006470	biological_process	protein dephosphorylation
F	0016311	biological_process	dephosphorylation
F	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
G	0006470	biological_process	protein dephosphorylation
G	0016311	biological_process	dephosphorylation
G	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
H	0006470	biological_process	protein dephosphorylation
H	0016311	biological_process	dephosphorylation
H	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
I	0006470	biological_process	protein dephosphorylation
I	0016311	biological_process	dephosphorylation
I	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
J	0006470	biological_process	protein dephosphorylation
J	0016311	biological_process	dephosphorylation
J	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
K	0006470	biological_process	protein dephosphorylation
K	0016311	biological_process	dephosphorylation
K	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity
L	0006470	biological_process	protein dephosphorylation
L	0016311	biological_process	dephosphorylation
L	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCqaGvsRSA

Chain	Residue	Details
A	ILE406-ALA416

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1573
Details	Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16806267","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17400920","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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