9BRU

Intact V-ATPase State 1 in synaptophysin knock-out isolated synaptic vesicles

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000166	molecular_function	nucleotide binding
0	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
0	0005524	molecular_function	ATP binding
0	0005654	cellular_component	nucleoplasm
0	0005737	cellular_component	cytoplasm
0	0005739	cellular_component	mitochondrion
0	0005764	cellular_component	lysosome
0	0005829	cellular_component	cytosol
0	0005886	cellular_component	plasma membrane
0	0005902	cellular_component	microvillus
0	0006811	biological_process	monoatomic ion transport
0	0006879	biological_process	intracellular iron ion homeostasis
0	0015078	molecular_function	proton transmembrane transporter activity
0	0016020	cellular_component	membrane
0	0016324	cellular_component	apical plasma membrane
0	0016887	molecular_function	ATP hydrolysis activity
0	0030133	cellular_component	transport vesicle
0	0030141	cellular_component	secretory granule
0	0030665	cellular_component	clathrin-coated vesicle membrane
0	0031410	cellular_component	cytoplasmic vesicle
0	0033176	cellular_component	proton-transporting V-type ATPase complex
0	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
0	0036295	biological_process	cellular response to increased oxygen levels
0	0038020	biological_process	insulin receptor recycling
0	0042592	biological_process	homeostatic process
0	0043209	cellular_component	myelin sheath
0	0046034	biological_process	ATP metabolic process
0	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
0	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
0	0097401	biological_process	synaptic vesicle lumen acidification
0	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
0	1902600	biological_process	proton transmembrane transport
1	0000166	molecular_function	nucleotide binding
1	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
1	0005524	molecular_function	ATP binding
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005739	cellular_component	mitochondrion
1	0005764	cellular_component	lysosome
1	0005829	cellular_component	cytosol
1	0005886	cellular_component	plasma membrane
1	0005902	cellular_component	microvillus
1	0006811	biological_process	monoatomic ion transport
1	0006879	biological_process	intracellular iron ion homeostasis
1	0015078	molecular_function	proton transmembrane transporter activity
1	0016020	cellular_component	membrane
1	0016324	cellular_component	apical plasma membrane
1	0016887	molecular_function	ATP hydrolysis activity
1	0030133	cellular_component	transport vesicle
1	0030141	cellular_component	secretory granule
1	0030665	cellular_component	clathrin-coated vesicle membrane
1	0031410	cellular_component	cytoplasmic vesicle
1	0033176	cellular_component	proton-transporting V-type ATPase complex
1	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
1	0036295	biological_process	cellular response to increased oxygen levels
1	0038020	biological_process	insulin receptor recycling
1	0042592	biological_process	homeostatic process
1	0043209	cellular_component	myelin sheath
1	0046034	biological_process	ATP metabolic process
1	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
1	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
1	0097401	biological_process	synaptic vesicle lumen acidification
1	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
1	1902600	biological_process	proton transmembrane transport
2	0000166	molecular_function	nucleotide binding
2	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
2	0005524	molecular_function	ATP binding
2	0005654	cellular_component	nucleoplasm
2	0005737	cellular_component	cytoplasm
2	0005739	cellular_component	mitochondrion
2	0005764	cellular_component	lysosome
2	0005829	cellular_component	cytosol
2	0005886	cellular_component	plasma membrane
2	0005902	cellular_component	microvillus
2	0006811	biological_process	monoatomic ion transport
2	0006879	biological_process	intracellular iron ion homeostasis
2	0015078	molecular_function	proton transmembrane transporter activity
2	0016020	cellular_component	membrane
2	0016324	cellular_component	apical plasma membrane
2	0016887	molecular_function	ATP hydrolysis activity
2	0030133	cellular_component	transport vesicle
2	0030141	cellular_component	secretory granule
2	0030665	cellular_component	clathrin-coated vesicle membrane
2	0031410	cellular_component	cytoplasmic vesicle
2	0033176	cellular_component	proton-transporting V-type ATPase complex
2	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
2	0036295	biological_process	cellular response to increased oxygen levels
2	0038020	biological_process	insulin receptor recycling
2	0042592	biological_process	homeostatic process
2	0043209	cellular_component	myelin sheath
2	0046034	biological_process	ATP metabolic process
2	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
2	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
2	0097401	biological_process	synaptic vesicle lumen acidification
2	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
2	1902600	biological_process	proton transmembrane transport
3	0000166	molecular_function	nucleotide binding
3	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
3	0001726	cellular_component	ruffle
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005886	cellular_component	plasma membrane
3	0005902	cellular_component	microvillus
3	0006811	biological_process	monoatomic ion transport
3	0007035	biological_process	vacuolar acidification
3	0016324	cellular_component	apical plasma membrane
3	0030665	cellular_component	clathrin-coated vesicle membrane
3	0030672	cellular_component	synaptic vesicle membrane
3	0031410	cellular_component	cytoplasmic vesicle
3	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
3	0042470	cellular_component	melanosome
3	0043209	cellular_component	myelin sheath
3	0046034	biological_process	ATP metabolic process
3	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
3	0097401	biological_process	synaptic vesicle lumen acidification
3	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
3	1902600	biological_process	proton transmembrane transport
4	0000166	molecular_function	nucleotide binding
4	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
4	0001726	cellular_component	ruffle
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0005886	cellular_component	plasma membrane
4	0005902	cellular_component	microvillus
4	0006811	biological_process	monoatomic ion transport
4	0007035	biological_process	vacuolar acidification
4	0016324	cellular_component	apical plasma membrane
4	0030665	cellular_component	clathrin-coated vesicle membrane
4	0030672	cellular_component	synaptic vesicle membrane
4	0031410	cellular_component	cytoplasmic vesicle
4	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
4	0042470	cellular_component	melanosome
4	0043209	cellular_component	myelin sheath
4	0046034	biological_process	ATP metabolic process
4	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
4	0097401	biological_process	synaptic vesicle lumen acidification
4	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
4	1902600	biological_process	proton transmembrane transport
5	0000166	molecular_function	nucleotide binding
5	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
5	0001726	cellular_component	ruffle
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005737	cellular_component	cytoplasm
5	0005829	cellular_component	cytosol
5	0005886	cellular_component	plasma membrane
5	0005902	cellular_component	microvillus
5	0006811	biological_process	monoatomic ion transport
5	0007035	biological_process	vacuolar acidification
5	0016324	cellular_component	apical plasma membrane
5	0030665	cellular_component	clathrin-coated vesicle membrane
5	0030672	cellular_component	synaptic vesicle membrane
5	0031410	cellular_component	cytoplasmic vesicle
5	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
5	0042470	cellular_component	melanosome
5	0043209	cellular_component	myelin sheath
5	0046034	biological_process	ATP metabolic process
5	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
5	0097401	biological_process	synaptic vesicle lumen acidification
5	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
5	1902600	biological_process	proton transmembrane transport
6	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
6	0005886	cellular_component	plasma membrane
6	0006811	biological_process	monoatomic ion transport
6	0015078	molecular_function	proton transmembrane transporter activity
6	0016020	cellular_component	membrane
6	0016887	molecular_function	ATP hydrolysis activity
6	0030665	cellular_component	clathrin-coated vesicle membrane
6	0030672	cellular_component	synaptic vesicle membrane
6	0031410	cellular_component	cytoplasmic vesicle
6	0033176	cellular_component	proton-transporting V-type ATPase complex
6	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
6	0038020	biological_process	insulin receptor recycling
6	0045177	cellular_component	apical part of cell
6	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
6	0097401	biological_process	synaptic vesicle lumen acidification
6	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
6	1902600	biological_process	proton transmembrane transport
7	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
7	0005654	cellular_component	nucleoplasm
7	0005813	cellular_component	centrosome
7	0005886	cellular_component	plasma membrane
7	0005929	cellular_component	cilium
7	0006811	biological_process	monoatomic ion transport
7	0007035	biological_process	vacuolar acidification
7	0015078	molecular_function	proton transmembrane transporter activity
7	0016020	cellular_component	membrane
7	0016887	molecular_function	ATP hydrolysis activity
7	0030030	biological_process	cell projection organization
7	0030665	cellular_component	clathrin-coated vesicle membrane
7	0031410	cellular_component	cytoplasmic vesicle
7	0033176	cellular_component	proton-transporting V-type ATPase complex
7	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
7	0038020	biological_process	insulin receptor recycling
7	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
7	0060271	biological_process	cilium assembly
7	0061512	biological_process	protein localization to cilium
7	0097401	biological_process	synaptic vesicle lumen acidification
7	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
7	1902600	biological_process	proton transmembrane transport
8	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
8	0005515	molecular_function	protein binding
8	0005737	cellular_component	cytoplasm
8	0005739	cellular_component	mitochondrion
8	0005768	cellular_component	endosome
8	0005829	cellular_component	cytosol
8	0005902	cellular_component	microvillus
8	0006811	biological_process	monoatomic ion transport
8	0016324	cellular_component	apical plasma membrane
8	0030665	cellular_component	clathrin-coated vesicle membrane
8	0030672	cellular_component	synaptic vesicle membrane
8	0031410	cellular_component	cytoplasmic vesicle
8	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
8	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
8	0051117	molecular_function	ATPase binding
8	0097401	biological_process	synaptic vesicle lumen acidification
8	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
8	1902600	biological_process	proton transmembrane transport
9	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
9	0005515	molecular_function	protein binding
9	0005737	cellular_component	cytoplasm
9	0005739	cellular_component	mitochondrion
9	0005768	cellular_component	endosome
9	0005829	cellular_component	cytosol
9	0005902	cellular_component	microvillus
9	0006811	biological_process	monoatomic ion transport
9	0016324	cellular_component	apical plasma membrane
9	0030665	cellular_component	clathrin-coated vesicle membrane
9	0030672	cellular_component	synaptic vesicle membrane
9	0031410	cellular_component	cytoplasmic vesicle
9	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
9	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
9	0051117	molecular_function	ATPase binding
9	0097401	biological_process	synaptic vesicle lumen acidification
9	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
9	1902600	biological_process	proton transmembrane transport
Q	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005768	cellular_component	endosome
Q	0005829	cellular_component	cytosol
Q	0005902	cellular_component	microvillus
Q	0006811	biological_process	monoatomic ion transport
Q	0016324	cellular_component	apical plasma membrane
Q	0030665	cellular_component	clathrin-coated vesicle membrane
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	0051117	molecular_function	ATPase binding
Q	0097401	biological_process	synaptic vesicle lumen acidification
Q	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
Q	1902600	biological_process	proton transmembrane transport
R	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
R	0005515	molecular_function	protein binding
R	0006811	biological_process	monoatomic ion transport
R	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
R	0030665	cellular_component	clathrin-coated vesicle membrane
R	0030672	cellular_component	synaptic vesicle membrane
R	0031410	cellular_component	cytoplasmic vesicle
R	0042470	cellular_component	melanosome
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	0097401	biological_process	synaptic vesicle lumen acidification
R	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
R	1902600	biological_process	proton transmembrane transport
T	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
T	0005515	molecular_function	protein binding
T	0006811	biological_process	monoatomic ion transport
T	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
T	0030665	cellular_component	clathrin-coated vesicle membrane
T	0030672	cellular_component	synaptic vesicle membrane
T	0031410	cellular_component	cytoplasmic vesicle
T	0042470	cellular_component	melanosome
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	0097401	biological_process	synaptic vesicle lumen acidification
T	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
T	1902600	biological_process	proton transmembrane transport
U	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
U	0005829	cellular_component	cytosol
U	0006811	biological_process	monoatomic ion transport
U	0006897	biological_process	endocytosis
U	0015078	molecular_function	proton transmembrane transporter activity
U	0016020	cellular_component	membrane
U	0016887	molecular_function	ATP hydrolysis activity
U	0030665	cellular_component	clathrin-coated vesicle membrane
U	0031410	cellular_component	cytoplasmic vesicle
U	0033176	cellular_component	proton-transporting V-type ATPase complex
U	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
U	0038020	biological_process	insulin receptor recycling
U	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
U	0097401	biological_process	synaptic vesicle lumen acidification
U	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
U	1902600	biological_process	proton transmembrane transport
V	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
V	0005515	molecular_function	protein binding
V	0006811	biological_process	monoatomic ion transport
V	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
V	0030665	cellular_component	clathrin-coated vesicle membrane
V	0030672	cellular_component	synaptic vesicle membrane
V	0031410	cellular_component	cytoplasmic vesicle
V	0042470	cellular_component	melanosome
V	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
V	0097401	biological_process	synaptic vesicle lumen acidification
V	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
V	1902600	biological_process	proton transmembrane transport
X	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
X	0006811	biological_process	monoatomic ion transport
X	0015078	molecular_function	proton transmembrane transporter activity
X	0016020	cellular_component	membrane
X	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
X	0016887	molecular_function	ATP hydrolysis activity
X	0030665	cellular_component	clathrin-coated vesicle membrane
X	0030672	cellular_component	synaptic vesicle membrane
X	0031410	cellular_component	cytoplasmic vesicle
X	0033176	cellular_component	proton-transporting V-type ATPase complex
X	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
X	0034220	biological_process	monoatomic ion transmembrane transport
X	0038020	biological_process	insulin receptor recycling
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	0097401	biological_process	synaptic vesicle lumen acidification
X	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
X	1902600	biological_process	proton transmembrane transport
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0005737	cellular_component	cytoplasm
a	0005794	cellular_component	Golgi apparatus
a	0005829	cellular_component	cytosol
a	0005886	cellular_component	plasma membrane
a	0006811	biological_process	monoatomic ion transport
a	0007035	biological_process	vacuolar acidification
a	0016020	cellular_component	membrane
a	0016241	biological_process	regulation of macroautophagy
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0016607	cellular_component	nuclear speck
a	0030665	cellular_component	clathrin-coated vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031410	cellular_component	cytoplasmic vesicle
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0042470	cellular_component	melanosome
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0048471	cellular_component	perinuclear region of cytoplasm
a	0051117	molecular_function	ATPase binding
a	0097401	biological_process	synaptic vesicle lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0005768	cellular_component	endosome
b	0006811	biological_process	monoatomic ion transport
b	0008553	molecular_function	P-type proton-exporting transporter activity
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
b	0016887	molecular_function	ATP hydrolysis activity
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0031410	cellular_component	cytoplasmic vesicle
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0038020	biological_process	insulin receptor recycling
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0005515	molecular_function	protein binding
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0005813	cellular_component	centrosome
d	0006811	biological_process	monoatomic ion transport
d	0006879	biological_process	intracellular iron ion homeostasis
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0008021	cellular_component	synaptic vesicle
d	0015078	molecular_function	proton transmembrane transporter activity
d	0016020	cellular_component	membrane
d	0016324	cellular_component	apical plasma membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0016887	molecular_function	ATP hydrolysis activity
d	0030030	biological_process	cell projection organization
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0030672	cellular_component	synaptic vesicle membrane
d	0031410	cellular_component	cytoplasmic vesicle
d	0032991	cellular_component	protein-containing complex
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0036295	biological_process	cellular response to increased oxygen levels
d	0038020	biological_process	insulin receptor recycling
d	0042592	biological_process	homeostatic process
d	0043679	cellular_component	axon terminus
d	0044877	molecular_function	protein-containing complex binding
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0060271	biological_process	cilium assembly
d	0097401	biological_process	synaptic vesicle lumen acidification
d	1902600	biological_process	proton transmembrane transport
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0006811	biological_process	monoatomic ion transport
e	0016020	cellular_component	membrane
e	0030665	cellular_component	clathrin-coated vesicle membrane
e	0030672	cellular_component	synaptic vesicle membrane
e	0031410	cellular_component	cytoplasmic vesicle
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0097401	biological_process	synaptic vesicle lumen acidification
e	1902600	biological_process	proton transmembrane transport
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0004518	molecular_function	nuclease activity
f	0004519	molecular_function	endonuclease activity
f	0004521	molecular_function	RNA endonuclease activity
f	0006811	biological_process	monoatomic ion transport
f	0006897	biological_process	endocytosis
f	0006898	biological_process	receptor-mediated endocytosis
f	0012505	cellular_component	endomembrane system
f	0016020	cellular_component	membrane
f	0016787	molecular_function	hydrolase activity
f	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
f	0030665	cellular_component	clathrin-coated vesicle membrane
f	0031410	cellular_component	cytoplasmic vesicle
f	0048388	biological_process	endosomal lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0005515	molecular_function	protein binding
g	0006811	biological_process	monoatomic ion transport
g	0007035	biological_process	vacuolar acidification
g	0007042	biological_process	lysosomal lumen acidification
g	0008021	cellular_component	synaptic vesicle
g	0008553	molecular_function	P-type proton-exporting transporter activity
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
g	0016887	molecular_function	ATP hydrolysis activity
g	0030177	biological_process	positive regulation of Wnt signaling pathway
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031410	cellular_component	cytoplasmic vesicle
g	0031625	molecular_function	ubiquitin protein ligase binding
g	0033176	cellular_component	proton-transporting V-type ATPase complex
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0038020	biological_process	insulin receptor recycling
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
g	0097401	biological_process	synaptic vesicle lumen acidification
g	0098588	cellular_component	bounding membrane of organelle
g	1902600	biological_process	proton transmembrane transport
g	1904093	biological_process	negative regulation of autophagic cell death
h	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
h	0005515	molecular_function	protein binding
h	0006811	biological_process	monoatomic ion transport
h	0007035	biological_process	vacuolar acidification
h	0007042	biological_process	lysosomal lumen acidification
h	0008021	cellular_component	synaptic vesicle
h	0008553	molecular_function	P-type proton-exporting transporter activity
h	0015078	molecular_function	proton transmembrane transporter activity
h	0016020	cellular_component	membrane
h	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
h	0016887	molecular_function	ATP hydrolysis activity
h	0030177	biological_process	positive regulation of Wnt signaling pathway
h	0030665	cellular_component	clathrin-coated vesicle membrane
h	0030672	cellular_component	synaptic vesicle membrane
h	0031410	cellular_component	cytoplasmic vesicle
h	0031625	molecular_function	ubiquitin protein ligase binding
h	0033176	cellular_component	proton-transporting V-type ATPase complex
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0038020	biological_process	insulin receptor recycling
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
h	0097401	biological_process	synaptic vesicle lumen acidification
h	0098588	cellular_component	bounding membrane of organelle
h	1902600	biological_process	proton transmembrane transport
h	1904093	biological_process	negative regulation of autophagic cell death
i	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
i	0005515	molecular_function	protein binding
i	0006811	biological_process	monoatomic ion transport
i	0007035	biological_process	vacuolar acidification
i	0007042	biological_process	lysosomal lumen acidification
i	0008021	cellular_component	synaptic vesicle
i	0008553	molecular_function	P-type proton-exporting transporter activity
i	0015078	molecular_function	proton transmembrane transporter activity
i	0016020	cellular_component	membrane
i	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
i	0016887	molecular_function	ATP hydrolysis activity
i	0030177	biological_process	positive regulation of Wnt signaling pathway
i	0030665	cellular_component	clathrin-coated vesicle membrane
i	0030672	cellular_component	synaptic vesicle membrane
i	0031410	cellular_component	cytoplasmic vesicle
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0033176	cellular_component	proton-transporting V-type ATPase complex
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0038020	biological_process	insulin receptor recycling
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
i	0097401	biological_process	synaptic vesicle lumen acidification
i	0098588	cellular_component	bounding membrane of organelle
i	1902600	biological_process	proton transmembrane transport
i	1904093	biological_process	negative regulation of autophagic cell death
j	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
j	0005515	molecular_function	protein binding
j	0006811	biological_process	monoatomic ion transport
j	0007035	biological_process	vacuolar acidification
j	0007042	biological_process	lysosomal lumen acidification
j	0008021	cellular_component	synaptic vesicle
j	0008553	molecular_function	P-type proton-exporting transporter activity
j	0015078	molecular_function	proton transmembrane transporter activity
j	0016020	cellular_component	membrane
j	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
j	0016887	molecular_function	ATP hydrolysis activity
j	0030177	biological_process	positive regulation of Wnt signaling pathway
j	0030665	cellular_component	clathrin-coated vesicle membrane
j	0030672	cellular_component	synaptic vesicle membrane
j	0031410	cellular_component	cytoplasmic vesicle
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0033176	cellular_component	proton-transporting V-type ATPase complex
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0038020	biological_process	insulin receptor recycling
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
j	0097401	biological_process	synaptic vesicle lumen acidification
j	0098588	cellular_component	bounding membrane of organelle
j	1902600	biological_process	proton transmembrane transport
j	1904093	biological_process	negative regulation of autophagic cell death
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0005515	molecular_function	protein binding
k	0006811	biological_process	monoatomic ion transport
k	0007035	biological_process	vacuolar acidification
k	0007042	biological_process	lysosomal lumen acidification
k	0008021	cellular_component	synaptic vesicle
k	0008553	molecular_function	P-type proton-exporting transporter activity
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
k	0016887	molecular_function	ATP hydrolysis activity
k	0030177	biological_process	positive regulation of Wnt signaling pathway
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031410	cellular_component	cytoplasmic vesicle
k	0031625	molecular_function	ubiquitin protein ligase binding
k	0033176	cellular_component	proton-transporting V-type ATPase complex
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0038020	biological_process	insulin receptor recycling
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
k	0097401	biological_process	synaptic vesicle lumen acidification
k	0098588	cellular_component	bounding membrane of organelle
k	1902600	biological_process	proton transmembrane transport
k	1904093	biological_process	negative regulation of autophagic cell death
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0005515	molecular_function	protein binding
l	0006811	biological_process	monoatomic ion transport
l	0007035	biological_process	vacuolar acidification
l	0007042	biological_process	lysosomal lumen acidification
l	0008021	cellular_component	synaptic vesicle
l	0008553	molecular_function	P-type proton-exporting transporter activity
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
l	0016887	molecular_function	ATP hydrolysis activity
l	0030177	biological_process	positive regulation of Wnt signaling pathway
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0031410	cellular_component	cytoplasmic vesicle
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0033176	cellular_component	proton-transporting V-type ATPase complex
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0038020	biological_process	insulin receptor recycling
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
l	0097401	biological_process	synaptic vesicle lumen acidification
l	0098588	cellular_component	bounding membrane of organelle
l	1902600	biological_process	proton transmembrane transport
l	1904093	biological_process	negative regulation of autophagic cell death
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0005515	molecular_function	protein binding
m	0006811	biological_process	monoatomic ion transport
m	0007035	biological_process	vacuolar acidification
m	0007042	biological_process	lysosomal lumen acidification
m	0008021	cellular_component	synaptic vesicle
m	0008553	molecular_function	P-type proton-exporting transporter activity
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
m	0016887	molecular_function	ATP hydrolysis activity
m	0030177	biological_process	positive regulation of Wnt signaling pathway
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0031410	cellular_component	cytoplasmic vesicle
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0033176	cellular_component	proton-transporting V-type ATPase complex
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0038020	biological_process	insulin receptor recycling
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
m	0097401	biological_process	synaptic vesicle lumen acidification
m	0098588	cellular_component	bounding membrane of organelle
m	1902600	biological_process	proton transmembrane transport
m	1904093	biological_process	negative regulation of autophagic cell death
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0005515	molecular_function	protein binding
n	0006811	biological_process	monoatomic ion transport
n	0007035	biological_process	vacuolar acidification
n	0007042	biological_process	lysosomal lumen acidification
n	0008021	cellular_component	synaptic vesicle
n	0008553	molecular_function	P-type proton-exporting transporter activity
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
n	0016887	molecular_function	ATP hydrolysis activity
n	0030177	biological_process	positive regulation of Wnt signaling pathway
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0031410	cellular_component	cytoplasmic vesicle
n	0031625	molecular_function	ubiquitin protein ligase binding
n	0033176	cellular_component	proton-transporting V-type ATPase complex
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0038020	biological_process	insulin receptor recycling
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
n	0097401	biological_process	synaptic vesicle lumen acidification
n	0098588	cellular_component	bounding membrane of organelle
n	1902600	biological_process	proton transmembrane transport
n	1904093	biological_process	negative regulation of autophagic cell death
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0005515	molecular_function	protein binding
o	0006811	biological_process	monoatomic ion transport
o	0007035	biological_process	vacuolar acidification
o	0007042	biological_process	lysosomal lumen acidification
o	0008021	cellular_component	synaptic vesicle
o	0008553	molecular_function	P-type proton-exporting transporter activity
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
o	0016887	molecular_function	ATP hydrolysis activity
o	0030177	biological_process	positive regulation of Wnt signaling pathway
o	0030665	cellular_component	clathrin-coated vesicle membrane
o	0030672	cellular_component	synaptic vesicle membrane
o	0031410	cellular_component	cytoplasmic vesicle
o	0031625	molecular_function	ubiquitin protein ligase binding
o	0033176	cellular_component	proton-transporting V-type ATPase complex
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0038020	biological_process	insulin receptor recycling
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
o	0097401	biological_process	synaptic vesicle lumen acidification
o	0098588	cellular_component	bounding membrane of organelle
o	1902600	biological_process	proton transmembrane transport
o	1904093	biological_process	negative regulation of autophagic cell death
p	0016020	cellular_component	membrane
p	0038023	molecular_function	signaling receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSVNWLISYS

Chain	Residue	Details
1	PRO446-SER455
3	PRO390-SER399

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P36543","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	204
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	72
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"UniProtKB","id":"P21283","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1130
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	128
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	423
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q93050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	186
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"UniProtKB","id":"Q2TA24","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	9
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"UniProtKB","id":"P63081","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"23863464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---