9BRI

Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL064-22

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004703	molecular_function	G protein-coupled receptor kinase activity
A	0005080	molecular_function	protein kinase C binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005543	molecular_function	phospholipid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007217	biological_process	tachykinin receptor signaling pathway
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008289	molecular_function	lipid binding
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0031965	cellular_component	nuclear membrane
A	0043066	biological_process	negative regulation of apoptotic process
A	0045444	biological_process	fat cell differentiation
A	0046777	biological_process	protein autophosphorylation
A	0047696	molecular_function	beta-adrenergic receptor kinase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGEVCaCqvratgkmyackrlekk.RIKK

Chain	Residue	Details
A	LEU192-LYS224

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	262
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"15542828","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---