9BPE
Joint X-ray/neutron structure of Thermus thermophilus serine hydroxymethyltransferase (TthSHMT) in internal aldimine state and folinic acid bound
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVvTSTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | HIS218-GLY234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|Ref.2 |
| Chain | Residue | Details |
| A | TYR51 | |
| B | HIS1200 | |
| B | HIS1225 | |
| B | GLY1258 | |
| A | GLY94 | |
| A | SER172 | |
| A | HIS200 | |
| A | HIS225 | |
| A | GLY258 | |
| B | TYR1051 | |
| B | GLY1094 | |
| B | SER1172 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00051 |
| Chain | Residue | Details |
| A | LEU117 | |
| A | GLY121 | |
| A | GLU242 | |
| B | LEU1117 | |
| B | GLY1121 | |
| B | GLU1242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Plays an important role in substrate specificity => ECO:0000255|HAMAP-Rule:MF_00051 |
| Chain | Residue | Details |
| A | HIS225 | |
| B | HIS1225 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00051, ECO:0000269|Ref.2 |
| Chain | Residue | Details |
| A | LLP226 | |
| B | LLP1226 |
