9BMG
State-2 of full-length human dynein-1 in 5mM ATPVi
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005868 | cellular_component | cytoplasmic dynein complex |
| A | 0005874 | cellular_component | microtubule |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0005938 | cellular_component | cell cortex |
| A | 0007052 | biological_process | mitotic spindle organization |
| A | 0007097 | biological_process | nuclear migration |
| A | 0008090 | biological_process | retrograde axonal transport |
| A | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030175 | cellular_component | filopodium |
| A | 0030286 | cellular_component | dynein complex |
| A | 0031122 | biological_process | cytoplasmic microtubule organization |
| A | 0032388 | biological_process | positive regulation of intracellular transport |
| A | 0033962 | biological_process | P-body assembly |
| A | 0034063 | biological_process | stress granule assembly |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0051293 | biological_process | establishment of spindle localization |
| A | 0051301 | biological_process | cell division |
| A | 0051959 | molecular_function | dynein light intermediate chain binding |
| A | 0060236 | biological_process | regulation of mitotic spindle organization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090235 | biological_process | regulation of metaphase plate congression |
| A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
| A | 1904115 | cellular_component | axon cytoplasm |
| A | 1905832 | biological_process | positive regulation of spindle assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS |
| Chain | Residue | Details |
| A | ILE2216-SER2226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | Region: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 249 |
| Details | Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 269 |
| Details | Region: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 229 |
| Details | Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 216 |
| Details | Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
