9BJZ
Structure of the human DDD-Ube2e2 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005634 | cellular_component | nucleus |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031461 | cellular_component | cullin-RING ubiquitin ligase complex |
| B | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0065003 | biological_process | protein-containing complex assembly |
| B | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| B | 1990756 | molecular_function | ubiquitin-like ligase-substrate adaptor activity |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| C | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| C | 0032814 | biological_process | regulation of natural killer cell activation |
| C | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0006513 | biological_process | protein monoubiquitination |
| D | 0006974 | biological_process | DNA damage response |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032020 | biological_process | ISG15-protein conjugation |
| D | 0042296 | molecular_function | ISG15 transferase activity |
| D | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| D | 0070534 | biological_process | protein K63-linked ubiquitination |
| D | 0070936 | biological_process | protein K48-linked ubiquitination |
| D | 0070979 | biological_process | protein K11-linked ubiquitination |
| D | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
Functional Information from PROSITE/UniProt
| site_id | PS00183 |
| Number of Residues | 16 |
| Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL |
| Chain | Residue | Details |
| D | TYR128-LEU143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 343 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 334 |
| Details | Region: {"description":"WD repeat beta-propeller C"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 369 |
| Details | Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 146 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
