9BJZ

Structure of the human DDD-Ube2e2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005634	cellular_component	nucleus
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0016567	biological_process	protein ubiquitination
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0044877	molecular_function	protein-containing complex binding
B	0065003	biological_process	protein-containing complex assembly
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000209	biological_process	protein polyubiquitination
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0016567	biological_process	protein ubiquitination
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
C	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032814	biological_process	regulation of natural killer cell activation
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0016567	biological_process	protein ubiquitination
D	0032020	biological_process	ISG15-protein conjugation
D	0042296	molecular_function	ISG15 transferase activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070534	biological_process	protein K63-linked ubiquitination
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL

Chain	Residue	Details
D	TYR128-LEU143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	51
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	52
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	52
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	46
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	36
Details	Repeat: {"description":"WD 8","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9SFM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	87
Details	Repeat: {"description":"WD 16","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	60
Details	Repeat: {"description":"WD 17","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	39
Details	Repeat: {"description":"WD 18","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	42
Details	Repeat: {"description":"WD 19","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	51
Details	Repeat: {"description":"WD 20","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	Repeat: {"description":"WD 21","evidences":[{"source":"PubMed","id":"41565821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9OTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9OUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	342
Details	Region: {"description":"WD40 beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	360
Details	Region: {"description":"WD40 beta-propeller C"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	369
Details	Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---