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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9BGH

Crystal structure of KRAS G12D in a transition state mimetic complex with CYPA and RMC-7977

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
B0000413biological_processprotein peptidyl-prolyl isomerization
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005178molecular_functionintegrin binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006457biological_processprotein folding
B0006469biological_processnegative regulation of protein kinase activity
B0006915biological_processapoptotic process
B0016018molecular_functioncyclosporin A binding
B0016853molecular_functionisomerase activity
B0030168biological_processplatelet activation
B0030593biological_processneutrophil chemotaxis
B0030595biological_processleukocyte chemotaxis
B0032148biological_processactivation of protein kinase B activity
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0034599biological_processcellular response to oxidative stress
B0042118biological_processendothelial cell activation
B0043410biological_processpositive regulation of MAPK cascade
B0045069biological_processregulation of viral genome replication
B0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
B0060352biological_processcell adhesion molecule production
B0061944biological_processnegative regulation of protein K48-linked ubiquitination
B0070527biological_processplatelet aggregation
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1904399molecular_functionheparan sulfate binding
B2001233biological_processregulation of apoptotic signaling pathway
C0000166molecular_functionnucleotide binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0009898cellular_componentcytoplasmic side of plasma membrane
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
D0000413biological_processprotein peptidyl-prolyl isomerization
D0001933biological_processnegative regulation of protein phosphorylation
D0001934biological_processpositive regulation of protein phosphorylation
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005178molecular_functionintegrin binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006457biological_processprotein folding
D0006469biological_processnegative regulation of protein kinase activity
D0006915biological_processapoptotic process
D0016018molecular_functioncyclosporin A binding
D0016853molecular_functionisomerase activity
D0030168biological_processplatelet activation
D0030593biological_processneutrophil chemotaxis
D0030595biological_processleukocyte chemotaxis
D0032148biological_processactivation of protein kinase B activity
D0032873biological_processnegative regulation of stress-activated MAPK cascade
D0034599biological_processcellular response to oxidative stress
D0042118biological_processendothelial cell activation
D0043410biological_processpositive regulation of MAPK cascade
D0045069biological_processregulation of viral genome replication
D0051092biological_processobsolete positive regulation of NF-kappaB transcription factor activity
D0060352biological_processcell adhesion molecule production
D0061944biological_processnegative regulation of protein K48-linked ubiquitination
D0070527biological_processplatelet aggregation
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1904399molecular_functionheparan sulfate binding
D2001233biological_processregulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
ChainResidueDetails
BTYR48-GLY65
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues312
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17742","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues16
DetailsMotif: {"description":"Effector region"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P01116","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-03-11

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