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9BCV

Cyclase domain of GC-A bound to ANP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001653molecular_functionpeptide receptor activity
A0004383molecular_functionguanylate cyclase activity
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005886cellular_componentplasma membrane
A0006182biological_processcGMP biosynthetic process
A0006468biological_processprotein phosphorylation
A0007166biological_processcell surface receptor signaling pathway
A0007168biological_processreceptor guanylyl cyclase signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007589biological_processbody fluid secretion
A0008015biological_processblood circulation
A0008217biological_processregulation of blood pressure
A0008528molecular_functionG protein-coupled peptide receptor activity
A0009190biological_processcyclic nucleotide biosynthetic process
A0010753biological_processpositive regulation of cGMP-mediated signaling
A0016020cellular_componentmembrane
A0016525biological_processnegative regulation of angiogenesis
A0016829molecular_functionlyase activity
A0016849molecular_functionphosphorus-oxygen lyase activity
A0016941molecular_functionnatriuretic peptide receptor activity
A0017046molecular_functionpeptide hormone binding
A0019934biological_processcGMP-mediated signaling
A0030308biological_processnegative regulation of cell growth
A0035556biological_processintracellular signal transduction
A0035810biological_processpositive regulation of urine volume
A0035815biological_processpositive regulation of renal sodium excretion
A0042417biological_processdopamine metabolic process
A0042562molecular_functionhormone binding
A0043114biological_processregulation of vascular permeability
A0043235cellular_componentreceptor complex
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0097746biological_processblood vessel diameter maintenance
A1990620cellular_componentANPR-A receptor complex
B0000166molecular_functionnucleotide binding
B0001653molecular_functionpeptide receptor activity
B0004383molecular_functionguanylate cyclase activity
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005886cellular_componentplasma membrane
B0006182biological_processcGMP biosynthetic process
B0006468biological_processprotein phosphorylation
B0007166biological_processcell surface receptor signaling pathway
B0007168biological_processreceptor guanylyl cyclase signaling pathway
B0007186biological_processG protein-coupled receptor signaling pathway
B0007589biological_processbody fluid secretion
B0008015biological_processblood circulation
B0008217biological_processregulation of blood pressure
B0008528molecular_functionG protein-coupled peptide receptor activity
B0009190biological_processcyclic nucleotide biosynthetic process
B0010753biological_processpositive regulation of cGMP-mediated signaling
B0016020cellular_componentmembrane
B0016525biological_processnegative regulation of angiogenesis
B0016829molecular_functionlyase activity
B0016849molecular_functionphosphorus-oxygen lyase activity
B0016941molecular_functionnatriuretic peptide receptor activity
B0017046molecular_functionpeptide hormone binding
B0019934biological_processcGMP-mediated signaling
B0030308biological_processnegative regulation of cell growth
B0035556biological_processintracellular signal transduction
B0035810biological_processpositive regulation of urine volume
B0035815biological_processpositive regulation of renal sodium excretion
B0042417biological_processdopamine metabolic process
B0042562molecular_functionhormone binding
B0043114biological_processregulation of vascular permeability
B0043235cellular_componentreceptor complex
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0097746biological_processblood vessel diameter maintenance
B1990620cellular_componentANPR-A receptor complex
Functional Information from PROSITE/UniProt
site_idPS00452
Number of Residues24
DetailsGUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GlkmprYcLFGDTVNtasrmE
ChainResidueDetails
AGLY983-GLU1006

site_idPS00458
Number of Residues18
DetailsANF_RECEPTORS Natriuretic peptides receptors signature. GPgCvYaAApVgRftaHW
ChainResidueDetails
AGLY115-TRP132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues260
DetailsDomain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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