9BCV

Cyclase domain of GC-A bound to ANP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001653	molecular_function	peptide receptor activity
A	0004383	molecular_function	guanylate cyclase activity
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005886	cellular_component	plasma membrane
A	0006182	biological_process	cGMP biosynthetic process
A	0006468	biological_process	protein phosphorylation
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007168	biological_process	receptor guanylyl cyclase signaling pathway
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007589	biological_process	body fluid secretion
A	0008015	biological_process	blood circulation
A	0008217	biological_process	regulation of blood pressure
A	0008528	molecular_function	G protein-coupled peptide receptor activity
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0010753	biological_process	positive regulation of cGMP-mediated signaling
A	0016020	cellular_component	membrane
A	0016525	biological_process	negative regulation of angiogenesis
A	0016829	molecular_function	lyase activity
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0016941	molecular_function	natriuretic peptide receptor activity
A	0017046	molecular_function	peptide hormone binding
A	0019934	biological_process	cGMP-mediated signaling
A	0030308	biological_process	negative regulation of cell growth
A	0035556	biological_process	intracellular signal transduction
A	0035810	biological_process	positive regulation of urine volume
A	0035815	biological_process	positive regulation of renal sodium excretion
A	0042417	biological_process	dopamine metabolic process
A	0042562	molecular_function	hormone binding
A	0043114	biological_process	regulation of vascular permeability
A	0043235	cellular_component	receptor complex
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0097746	biological_process	blood vessel diameter maintenance
A	1990620	cellular_component	ANPR-A receptor complex
B	0000166	molecular_function	nucleotide binding
B	0001653	molecular_function	peptide receptor activity
B	0004383	molecular_function	guanylate cyclase activity
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005886	cellular_component	plasma membrane
B	0006182	biological_process	cGMP biosynthetic process
B	0006468	biological_process	protein phosphorylation
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007168	biological_process	receptor guanylyl cyclase signaling pathway
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007589	biological_process	body fluid secretion
B	0008015	biological_process	blood circulation
B	0008217	biological_process	regulation of blood pressure
B	0008528	molecular_function	G protein-coupled peptide receptor activity
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0010753	biological_process	positive regulation of cGMP-mediated signaling
B	0016020	cellular_component	membrane
B	0016525	biological_process	negative regulation of angiogenesis
B	0016829	molecular_function	lyase activity
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0016941	molecular_function	natriuretic peptide receptor activity
B	0017046	molecular_function	peptide hormone binding
B	0019934	biological_process	cGMP-mediated signaling
B	0030308	biological_process	negative regulation of cell growth
B	0035556	biological_process	intracellular signal transduction
B	0035810	biological_process	positive regulation of urine volume
B	0035815	biological_process	positive regulation of renal sodium excretion
B	0042417	biological_process	dopamine metabolic process
B	0042562	molecular_function	hormone binding
B	0043114	biological_process	regulation of vascular permeability
B	0043235	cellular_component	receptor complex
B	0048662	biological_process	negative regulation of smooth muscle cell proliferation
B	0097746	biological_process	blood vessel diameter maintenance
B	1990620	cellular_component	ANPR-A receptor complex

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GlkmprYcLFGDTVNtasrmE

Chain	Residue	Details
A	GLY983-GLU1006

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site_id	PS00458
Number of Residues	18
Details	ANF_RECEPTORS Natriuretic peptides receptors signature. GPgCvYaAApVgRftaHW

Chain	Residue	Details
A	GLY115-TRP132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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