9BC4

Transglutaminase 2 - Intermediate State

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0008233	molecular_function	peptidase activity
A	0010467	biological_process	gene expression
A	0014046	biological_process	dopamine secretion
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0018149	biological_process	peptide cross-linking
A	0018277	biological_process	protein deamination
A	0031012	cellular_component	extracellular matrix
A	0032471	biological_process	negative regulation of endoplasmic reticulum calcium ion concentration
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043277	biological_process	apoptotic cell clearance
A	0043547	biological_process	positive regulation of GTPase activity
A	0045785	biological_process	positive regulation of cell adhesion
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050568	molecular_function	protein-glutamine glutaminase activity
A	0050769	biological_process	positive regulation of neurogenesis
A	0051057	biological_process	positive regulation of small GTPase mediated signal transduction
A	0051561	biological_process	positive regulation of mitochondrial calcium ion concentration
A	0060348	biological_process	bone development
A	0060445	biological_process	branching involved in salivary gland morphogenesis
A	0060662	biological_process	salivary gland cavitation
A	0070062	cellular_component	extracellular exosome
A	0071314	biological_process	cellular response to cocaine
A	0120294	molecular_function	peptide serotonyltransferase activity
A	0120295	molecular_function	histone serotonyltransferase activity
A	0120296	molecular_function	peptide dopaminyltransferase activity
A	0120297	molecular_function	histone dopaminyltransferase activity
A	0120298	molecular_function	peptide noradrenalinyltransferase activity
A	0120299	molecular_function	peptide histaminyltransferase activity
A	1903351	biological_process	cellular response to dopamine
A	1903672	biological_process	positive regulation of sprouting angiogenesis
A	1904015	biological_process	cellular response to serotonin
A	2000425	biological_process	regulation of apoptotic cell clearance

Functional Information from PROSITE/UniProt

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG

Chain	Residue	Details
A	GLY275-GLY292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7649299","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"8943303","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00488","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31991788","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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