9BB0

D-Dopachrome Tautomerase with 4-Hydroxyphenylpyruvate Bound in Catalytic Site at Atomic (0.98 Angstrom) Resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004167	molecular_function	dopachrome isomerase activity
AAA	0005126	molecular_function	cytokine receptor binding
AAA	0005615	cellular_component	extracellular space
AAA	0005737	cellular_component	cytoplasm
AAA	0010760	biological_process	negative regulation of macrophage chemotaxis
AAA	0016829	molecular_function	lyase activity
AAA	0032760	biological_process	positive regulation of tumor necrosis factor production
AAA	0033981	molecular_function	D-dopachrome decarboxylase activity
AAA	0042438	biological_process	melanin biosynthetic process
AAA	0050178	molecular_function	phenylpyruvate tautomerase activity
AAA	0050729	biological_process	positive regulation of inflammatory response
AAA	0070062	cellular_component	extracellular exosome
AAA	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
BBB	0004167	molecular_function	dopachrome isomerase activity
BBB	0005126	molecular_function	cytokine receptor binding
BBB	0005615	cellular_component	extracellular space
BBB	0005737	cellular_component	cytoplasm
BBB	0010760	biological_process	negative regulation of macrophage chemotaxis
BBB	0016829	molecular_function	lyase activity
BBB	0032760	biological_process	positive regulation of tumor necrosis factor production
BBB	0033981	molecular_function	D-dopachrome decarboxylase activity
BBB	0042438	biological_process	melanin biosynthetic process
BBB	0050178	molecular_function	phenylpyruvate tautomerase activity
BBB	0050729	biological_process	positive regulation of inflammatory response
BBB	0070062	cellular_component	extracellular exosome
BBB	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
CCC	0004167	molecular_function	dopachrome isomerase activity
CCC	0005126	molecular_function	cytokine receptor binding
CCC	0005615	cellular_component	extracellular space
CCC	0005737	cellular_component	cytoplasm
CCC	0010760	biological_process	negative regulation of macrophage chemotaxis
CCC	0016829	molecular_function	lyase activity
CCC	0032760	biological_process	positive regulation of tumor necrosis factor production
CCC	0033981	molecular_function	D-dopachrome decarboxylase activity
CCC	0042438	biological_process	melanin biosynthetic process
CCC	0050178	molecular_function	phenylpyruvate tautomerase activity
CCC	0050729	biological_process	positive regulation of inflammatory response
CCC	0070062	cellular_component	extracellular exosome
CCC	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAqlsIsSIGvVG

Chain	Residue	Details
AAA	GLU54-GLY68

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"N-acetylproline","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O35215","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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