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9B85

Cryo-EM structure of human dynactin complex bound to Chlamydia effector Dre1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005815cellular_componentmicrotubule organizing center
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005869cellular_componentdynactin complex
A0005875cellular_componentmicrotubule associated complex
A0005938cellular_componentcell cortex
A0007010biological_processcytoskeleton organization
A0016192biological_processvesicle-mediated transport
A0070062cellular_componentextracellular exosome
B0000166molecular_functionnucleotide binding
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005815cellular_componentmicrotubule organizing center
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005869cellular_componentdynactin complex
B0005875cellular_componentmicrotubule associated complex
B0005938cellular_componentcell cortex
B0007010biological_processcytoskeleton organization
B0016192biological_processvesicle-mediated transport
B0070062cellular_componentextracellular exosome
C0000166molecular_functionnucleotide binding
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005815cellular_componentmicrotubule organizing center
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005869cellular_componentdynactin complex
C0005875cellular_componentmicrotubule associated complex
C0005938cellular_componentcell cortex
C0007010biological_processcytoskeleton organization
C0016192biological_processvesicle-mediated transport
C0070062cellular_componentextracellular exosome
D0000166molecular_functionnucleotide binding
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005815cellular_componentmicrotubule organizing center
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005869cellular_componentdynactin complex
D0005875cellular_componentmicrotubule associated complex
D0005938cellular_componentcell cortex
D0007010biological_processcytoskeleton organization
D0016192biological_processvesicle-mediated transport
D0070062cellular_componentextracellular exosome
E0000166molecular_functionnucleotide binding
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005815cellular_componentmicrotubule organizing center
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005869cellular_componentdynactin complex
E0005875cellular_componentmicrotubule associated complex
E0005938cellular_componentcell cortex
E0007010biological_processcytoskeleton organization
E0016192biological_processvesicle-mediated transport
E0070062cellular_componentextracellular exosome
F0000166molecular_functionnucleotide binding
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005815cellular_componentmicrotubule organizing center
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005869cellular_componentdynactin complex
F0005875cellular_componentmicrotubule associated complex
F0005938cellular_componentcell cortex
F0007010biological_processcytoskeleton organization
F0016192biological_processvesicle-mediated transport
F0070062cellular_componentextracellular exosome
G0000166molecular_functionnucleotide binding
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005815cellular_componentmicrotubule organizing center
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005869cellular_componentdynactin complex
G0005875cellular_componentmicrotubule associated complex
G0005938cellular_componentcell cortex
G0007010biological_processcytoskeleton organization
G0016192biological_processvesicle-mediated transport
G0070062cellular_componentextracellular exosome
H0000166molecular_functionnucleotide binding
H0000776cellular_componentkinetochore
H0000785cellular_componentchromatin
H0001738biological_processmorphogenesis of a polarized epithelium
H0005200molecular_functionstructural constituent of cytoskeleton
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005884cellular_componentactin filament
H0005886cellular_componentplasma membrane
H0005903cellular_componentbrush border
H0005911cellular_componentcell-cell junction
H0005912cellular_componentadherens junction
H0005925cellular_componentfocal adhesion
H0006338biological_processchromatin remodeling
H0006357biological_processregulation of transcription by RNA polymerase II
H0007010biological_processcytoskeleton organization
H0007020biological_processmicrotubule nucleation
H0007163biological_processestablishment or maintenance of cell polarity
H0007409biological_processaxonogenesis
H0008284biological_processpositive regulation of cell population proliferation
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016363cellular_componentnuclear matrix
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0019894molecular_functionkinesin binding
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030027cellular_componentlamellipodium
H0030071biological_processregulation of mitotic metaphase/anaphase transition
H0030235molecular_functionnitric-oxide synthase regulator activity
H0030424cellular_componentaxon
H0030863cellular_componentcortical cytoskeleton
H0030957molecular_functionTat protein binding
H0031492molecular_functionnucleosomal DNA binding
H0031982cellular_componentvesicle
H0032991cellular_componentprotein-containing complex
H0034333biological_processadherens junction assembly
H0035267cellular_componentNuA4 histone acetyltransferase complex
H0035633biological_processmaintenance of blood-brain barrier
H0036464cellular_componentcytoplasmic ribonucleoprotein granule
H0042802molecular_functionidentical protein binding
H0042981biological_processregulation of apoptotic process
H0043296cellular_componentapical junction complex
H0044305cellular_componentcalyx of Held
H0045176biological_processapical protein localization
H0045202cellular_componentsynapse
H0045582biological_processpositive regulation of T cell differentiation
H0045596biological_processnegative regulation of cell differentiation
H0045597biological_processpositive regulation of cell differentiation
H0045663biological_processpositive regulation of myoblast differentiation
H0045893biological_processpositive regulation of DNA-templated transcription
H0048156molecular_functiontau protein binding
H0048870biological_processcell motility
H0050998molecular_functionnitric-oxide synthase binding
H0051621biological_processregulation of norepinephrine uptake
H0051623biological_processpositive regulation of norepinephrine uptake
H0051726biological_processregulation of cell cycle
H0070062cellular_componentextracellular exosome
H0070160cellular_componenttight junction
H0070316biological_processregulation of G0 to G1 transition
H0070527biological_processplatelet aggregation
H0071896biological_processprotein localization to adherens junction
H0072562cellular_componentblood microparticle
H0072749biological_processcellular response to cytochalasin B
H0097433cellular_componentdense body
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098793cellular_componentpresynapse
H0098871cellular_componentpostsynaptic actin cytoskeleton
H0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
H0098974biological_processpostsynaptic actin cytoskeleton organization
H0098978cellular_componentglutamatergic synapse
H0141108molecular_functiontransporter regulator activity
H0150111biological_processregulation of transepithelial transport
H1900242biological_processregulation of synaptic vesicle endocytosis
H1902459biological_processpositive regulation of stem cell population maintenance
H1903076biological_processregulation of protein localization to plasma membrane
H1905168biological_processpositive regulation of double-strand break repair via homologous recombination
H1990904cellular_componentribonucleoprotein complex
H2000045biological_processregulation of G1/S transition of mitotic cell cycle
H2000779biological_processregulation of double-strand break repair
H2000781biological_processpositive regulation of double-strand break repair
H2000819biological_processregulation of nucleotide-excision repair
I0000166molecular_functionnucleotide binding
I0005200molecular_functionstructural constituent of cytoskeleton
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005815cellular_componentmicrotubule organizing center
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005869cellular_componentdynactin complex
I0005875cellular_componentmicrotubule associated complex
I0005938cellular_componentcell cortex
I0007010biological_processcytoskeleton organization
I0016192biological_processvesicle-mediated transport
I0070062cellular_componentextracellular exosome
J0005200molecular_functionstructural constituent of cytoskeleton
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005869cellular_componentdynactin complex
J0007010biological_processcytoskeleton organization
J0035578cellular_componentazurophil granule lumen
J0098958biological_processretrograde axonal transport of mitochondrion
J1904115cellular_componentaxon cytoplasm
J1904813cellular_componentficolin-1-rich granule lumen
K0000776cellular_componentkinetochore
K0000922cellular_componentspindle pole
K0001725cellular_componentstress fiber
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005868cellular_componentcytoplasmic dynein complex
K0005869cellular_componentdynactin complex
K0005925cellular_componentfocal adhesion
K0005938cellular_componentcell cortex
K0030017cellular_componentsarcomere
L0000776cellular_componentkinetochore
L0005515molecular_functionprotein binding
L0005813cellular_componentcentrosome
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005869cellular_componentdynactin complex
M0000776cellular_componentkinetochore
M0005515molecular_functionprotein binding
M0005813cellular_componentcentrosome
M0005829cellular_componentcytosol
M0005856cellular_componentcytoskeleton
M0005869cellular_componentdynactin complex
M0007052biological_processmitotic spindle organization
M0015630cellular_componentmicrotubule cytoskeleton
M0070840molecular_functiondynein complex binding
N0003779molecular_functionactin binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0008290cellular_componentF-actin capping protein complex
N0015629cellular_componentactin cytoskeleton
N0030036biological_processactin cytoskeleton organization
N0030863cellular_componentcortical cytoskeleton
N0034329biological_processcell junction assembly
N0045296molecular_functioncadherin binding
N0051015molecular_functionactin filament binding
N0051016biological_processbarbed-end actin filament capping
N0051693biological_processactin filament capping
N0065003biological_processprotein-containing complex assembly
N0070062cellular_componentextracellular exosome
N0071203cellular_componentWASH complex
O0003779molecular_functionactin binding
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0005903cellular_componentbrush border
O0008290cellular_componentF-actin capping protein complex
O0014069cellular_componentpostsynaptic density
O0015629cellular_componentactin cytoskeleton
O0016020cellular_componentmembrane
O0030017cellular_componentsarcomere
O0030027cellular_componentlamellipodium
O0030036biological_processactin cytoskeleton organization
O0030863cellular_componentcortical cytoskeleton
O0045296molecular_functioncadherin binding
O0051016biological_processbarbed-end actin filament capping
O0051693biological_processactin filament capping
O0070062cellular_componentextracellular exosome
O0071203cellular_componentWASH complex
O0098685cellular_componentSchaffer collateral - CA1 synapse
O0098686cellular_componenthippocampal mossy fiber to CA3 synapse
O0120212cellular_componentsperm head-tail coupling apparatus
p0000776cellular_componentkinetochore
p0005515molecular_functionprotein binding
p0005737cellular_componentcytoplasm
p0005813cellular_componentcentrosome
p0005829cellular_componentcytosol
p0005856cellular_componentcytoskeleton
p0005869cellular_componentdynactin complex
p0005874cellular_componentmicrotubule
p0007017biological_processmicrotubule-based process
p0007052biological_processmitotic spindle organization
p0007080biological_processmitotic metaphase chromosome alignment
p0016020cellular_componentmembrane
p0019901molecular_functionprotein kinase binding
p0030286cellular_componentdynein complex
p0030426cellular_componentgrowth cone
p0030507molecular_functionspectrin binding
p0031982cellular_componentvesicle
p0036064cellular_componentciliary basal body
p0042802molecular_functionidentical protein binding
p0070062cellular_componentextracellular exosome
p0071539biological_processprotein localization to centrosome
P0000776cellular_componentkinetochore
P0005515molecular_functionprotein binding
P0005737cellular_componentcytoplasm
P0005813cellular_componentcentrosome
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005869cellular_componentdynactin complex
P0005874cellular_componentmicrotubule
P0007017biological_processmicrotubule-based process
P0007052biological_processmitotic spindle organization
P0007080biological_processmitotic metaphase chromosome alignment
P0016020cellular_componentmembrane
P0019901molecular_functionprotein kinase binding
P0030286cellular_componentdynein complex
P0030426cellular_componentgrowth cone
P0030507molecular_functionspectrin binding
P0031982cellular_componentvesicle
P0036064cellular_componentciliary basal body
P0042802molecular_functionidentical protein binding
P0070062cellular_componentextracellular exosome
P0071539biological_processprotein localization to centrosome
q0000776cellular_componentkinetochore
q0005515molecular_functionprotein binding
q0005737cellular_componentcytoplasm
q0005813cellular_componentcentrosome
q0005829cellular_componentcytosol
q0005856cellular_componentcytoskeleton
q0005869cellular_componentdynactin complex
q0005874cellular_componentmicrotubule
q0007017biological_processmicrotubule-based process
q0007052biological_processmitotic spindle organization
q0007080biological_processmitotic metaphase chromosome alignment
q0016020cellular_componentmembrane
q0019901molecular_functionprotein kinase binding
q0030286cellular_componentdynein complex
q0030426cellular_componentgrowth cone
q0030507molecular_functionspectrin binding
q0031982cellular_componentvesicle
q0036064cellular_componentciliary basal body
q0042802molecular_functionidentical protein binding
q0070062cellular_componentextracellular exosome
q0071539biological_processprotein localization to centrosome
Q0000776cellular_componentkinetochore
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005813cellular_componentcentrosome
Q0005829cellular_componentcytosol
Q0005856cellular_componentcytoskeleton
Q0005869cellular_componentdynactin complex
Q0005874cellular_componentmicrotubule
Q0007017biological_processmicrotubule-based process
Q0007052biological_processmitotic spindle organization
Q0007080biological_processmitotic metaphase chromosome alignment
Q0016020cellular_componentmembrane
Q0019901molecular_functionprotein kinase binding
Q0030286cellular_componentdynein complex
Q0030426cellular_componentgrowth cone
Q0030507molecular_functionspectrin binding
Q0031982cellular_componentvesicle
Q0036064cellular_componentciliary basal body
Q0042802molecular_functionidentical protein binding
Q0070062cellular_componentextracellular exosome
Q0071539biological_processprotein localization to centrosome
Functional Information from PROSITE/UniProt
site_idPS00231
Number of Residues6
DetailsF_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD
ChainResidueDetails
OCYS62-ASP67

site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
HTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WVSKkEYEE
ChainResidueDetails
ATRP357-GLU365
HTRP356-GLU364

site_idPS00748
Number of Residues9
DetailsF_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV
ChainResidueDetails
NVAL196-VAL204

site_idPS00749
Number of Residues11
DetailsF_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR
ChainResidueDetails
NLYS256-ARG266

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR
ChainResidueDetails
ALEU109-ARG121
HLEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"29343822","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsCross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsCross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9QUR2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2006","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Kanor S.","Tissot J.-D.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues24
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Ramsay A.","Leung H.Y."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q99KJ8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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