9B83

Cryo-EM structure of human ADAR1 in complex with dsRNA derived from human GLI1 gene

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0003726	molecular_function	double-stranded RNA adenosine deaminase activity
A	0004000	molecular_function	adenosine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006382	biological_process	adenosine to inosine editing
A	0006396	biological_process	RNA processing
A	0006397	biological_process	mRNA processing
A	0008251	molecular_function	tRNA-specific adenosine deaminase activity
A	0008643	biological_process	carbohydrate transport
A	0009615	biological_process	response to virus
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016553	biological_process	base conversion or substitution editing
A	0016556	biological_process	mRNA modification
A	0016787	molecular_function	hydrolase activity
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0031054	biological_process	pre-miRNA processing
A	0031981	cellular_component	nuclear lumen
A	0035455	biological_process	response to interferon-alpha
A	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
A	0044530	cellular_component	supraspliceosomal complex
A	0045070	biological_process	positive regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0055085	biological_process	transmembrane transport
A	0070922	biological_process	RISC complex assembly
A	0098586	biological_process	cellular response to virus
B	0002376	biological_process	immune system process
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003725	molecular_function	double-stranded RNA binding
B	0003726	molecular_function	double-stranded RNA adenosine deaminase activity
B	0004000	molecular_function	adenosine deaminase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006382	biological_process	adenosine to inosine editing
B	0006396	biological_process	RNA processing
B	0006397	biological_process	mRNA processing
B	0008251	molecular_function	tRNA-specific adenosine deaminase activity
B	0008643	biological_process	carbohydrate transport
B	0009615	biological_process	response to virus
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0016553	biological_process	base conversion or substitution editing
B	0016556	biological_process	mRNA modification
B	0016787	molecular_function	hydrolase activity
B	0031047	biological_process	regulatory ncRNA-mediated gene silencing
B	0031054	biological_process	pre-miRNA processing
B	0031981	cellular_component	nuclear lumen
B	0035455	biological_process	response to interferon-alpha
B	0044387	biological_process	negative regulation of protein kinase activity by regulation of protein phosphorylation
B	0044530	cellular_component	supraspliceosomal complex
B	0045070	biological_process	positive regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0055085	biological_process	transmembrane transport
B	0070922	biological_process	RISC complex assembly
B	0098586	biological_process	cellular response to virus

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-158-ASN-141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	335
Details	Domain: {"description":"A to I editase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---