9B69
GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2780 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| C | VAL7-ALA528 | |
| C | THR623-ASN797 | |
| A | VAL7-ALA528 | |
| A | THR623-ASN797 | |
| B | VAL7-ALA528 | |
| B | THR623-ASN797 | |
| D | VAL7-ALA528 | |
| D | THR623-ASN797 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| C | TYR529-VAL549 | |
| C | LEU602-TYR622 | |
| A | TYR529-VAL549 | |
| A | LEU602-TYR622 | |
| B | TYR529-VAL549 | |
| B | LEU602-TYR622 | |
| D | TYR529-VAL549 | |
| D | LEU602-TYR622 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 320 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| C | SER550-GLU576 | |
| D | SER550-GLU576 | |
| D | ASP596-SER601 | |
| D | GLU819-GLY868 | |
| C | ASP596-SER601 | |
| C | GLU819-GLY868 | |
| A | SER550-GLU576 | |
| A | ASP596-SER601 | |
| A | GLU819-GLY868 | |
| B | SER550-GLU576 | |
| B | ASP596-SER601 | |
| B | GLU819-GLY868 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| C | PHE577-GLN592 | |
| A | PHE577-GLN592 | |
| B | PHE577-GLN592 | |
| D | PHE577-GLN592 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| C | GLN593-CYS595 | |
| A | GLN593-CYS595 | |
| B | GLN593-CYS595 | |
| D | GLN593-CYS595 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=M4 |
| Chain | Residue | Details |
| C | VAL798-ILE818 | |
| A | VAL798-ILE818 | |
| B | VAL798-ILE818 | |
| D | VAL798-ILE818 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
| Chain | Residue | Details |
| C | PRO484 | |
| A | SER660 | |
| A | THR661 | |
| A | GLU711 | |
| B | PRO484 | |
| B | THR486 | |
| B | ARG491 | |
| B | SER660 | |
| B | THR661 | |
| B | GLU711 | |
| D | PRO484 | |
| C | THR486 | |
| D | THR486 | |
| D | ARG491 | |
| D | SER660 | |
| D | THR661 | |
| D | GLU711 | |
| C | ARG491 | |
| C | SER660 | |
| C | THR661 | |
| C | GLU711 | |
| A | PRO484 | |
| A | THR486 | |
| A | ARG491 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| C | ARG459 | |
| D | ARG459 | |
| D | ARG666 | |
| D | LYS758 | |
| C | ARG666 | |
| C | LYS758 | |
| A | ARG459 | |
| A | ARG666 | |
| A | LYS758 | |
| B | ARG459 | |
| B | ARG666 | |
| B | LYS758 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| C | ILE639 | |
| A | ILE639 | |
| B | ILE639 | |
| D | ILE639 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| C | SER668 | |
| A | SER668 | |
| B | SER668 | |
| D | SER668 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| C | SER702 | |
| A | SER702 | |
| B | SER702 | |
| D | SER702 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819 |
| Chain | Residue | Details |
| C | SER845 | |
| D | SER845 | |
| D | SER848 | |
| D | ASN865 | |
| C | SER848 | |
| C | ASN865 | |
| A | SER845 | |
| A | SER848 | |
| A | ASN865 | |
| B | SER845 | |
| B | SER848 | |
| B | ASN865 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15240807, ECO:0000269|PubMed:20547133 |
| Chain | Residue | Details |
| C | LYS861 | |
| A | LYS861 | |
| B | LYS861 | |
| D | LYS861 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| C | CYS595 | |
| C | CYS821 | |
| A | CYS595 | |
| A | CYS821 | |
| B | CYS595 | |
| B | CYS821 | |
| D | CYS595 | |
| D | CYS821 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 |
| Chain | Residue | Details |
| C | ASN241 | |
| A | ASN241 | |
| B | ASN241 | |
| D | ASN241 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| C | ASN355 | |
| A | ASN355 | |
| B | ASN355 | |
| D | ASN355 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN391 | |
| C | ASN398 | |
| A | ASN391 | |
| A | ASN398 | |
| B | ASN391 | |
| B | ASN398 | |
| D | ASN391 | |
| D | ASN398 |
