Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9B67

GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005262	molecular_function	calcium channel activity
E	0005515	molecular_function	protein binding
E	0005891	cellular_component	voltage-gated calcium channel complex
E	0006612	biological_process	protein targeting to membrane
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0007528	biological_process	neuromuscular junction development
E	0009986	cellular_component	cell surface
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0019226	biological_process	transmission of nerve impulse
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0035255	molecular_function	ionotropic glutamate receptor binding
E	0036477	cellular_component	somatodendritic compartment
E	0042391	biological_process	regulation of membrane potential
E	0043005	cellular_component	neuron projection
E	0044300	cellular_component	cerebellar mossy fiber
E	0045202	cellular_component	synapse
E	0050877	biological_process	nervous system process
E	0051592	biological_process	response to calcium ion
E	0051899	biological_process	membrane depolarization
E	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
E	0060081	biological_process	membrane hyperpolarization
E	0060082	biological_process	eye blink reflex
E	0070588	biological_process	calcium ion transmembrane transport
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098839	cellular_component	postsynaptic density membrane
E	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
E	2000311	biological_process	regulation of AMPA receptor activity
F	0005245	molecular_function	voltage-gated calcium channel activity
F	0005262	molecular_function	calcium channel activity
F	0005515	molecular_function	protein binding
F	0005891	cellular_component	voltage-gated calcium channel complex
F	0006612	biological_process	protein targeting to membrane
F	0006811	biological_process	monoatomic ion transport
F	0006816	biological_process	calcium ion transport
F	0007528	biological_process	neuromuscular junction development
F	0009986	cellular_component	cell surface
F	0016020	cellular_component	membrane
F	0016247	molecular_function	channel regulator activity
F	0019226	biological_process	transmission of nerve impulse
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0035255	molecular_function	ionotropic glutamate receptor binding
F	0036477	cellular_component	somatodendritic compartment
F	0042391	biological_process	regulation of membrane potential
F	0043005	cellular_component	neuron projection
F	0044300	cellular_component	cerebellar mossy fiber
F	0045202	cellular_component	synapse
F	0050877	biological_process	nervous system process
F	0051592	biological_process	response to calcium ion
F	0051899	biological_process	membrane depolarization
F	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
F	0060081	biological_process	membrane hyperpolarization
F	0060082	biological_process	eye blink reflex
F	0070588	biological_process	calcium ion transmembrane transport
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
F	0098839	cellular_component	postsynaptic density membrane
F	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
F	0098978	cellular_component	glutamatergic synapse
F	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
F	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
F	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
F	2000311	biological_process	regulation of AMPA receptor activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005262	molecular_function	calcium channel activity
G	0005515	molecular_function	protein binding
G	0005891	cellular_component	voltage-gated calcium channel complex
G	0006612	biological_process	protein targeting to membrane
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0007528	biological_process	neuromuscular junction development
G	0009986	cellular_component	cell surface
G	0016020	cellular_component	membrane
G	0016247	molecular_function	channel regulator activity
G	0019226	biological_process	transmission of nerve impulse
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0035255	molecular_function	ionotropic glutamate receptor binding
G	0036477	cellular_component	somatodendritic compartment
G	0042391	biological_process	regulation of membrane potential
G	0043005	cellular_component	neuron projection
G	0044300	cellular_component	cerebellar mossy fiber
G	0045202	cellular_component	synapse
G	0050877	biological_process	nervous system process
G	0051592	biological_process	response to calcium ion
G	0051899	biological_process	membrane depolarization
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0060081	biological_process	membrane hyperpolarization
G	0060082	biological_process	eye blink reflex
G	0070588	biological_process	calcium ion transmembrane transport
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
G	0098839	cellular_component	postsynaptic density membrane
G	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
G	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
G	2000311	biological_process	regulation of AMPA receptor activity
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005262	molecular_function	calcium channel activity
H	0005515	molecular_function	protein binding
H	0005891	cellular_component	voltage-gated calcium channel complex
H	0006612	biological_process	protein targeting to membrane
H	0006811	biological_process	monoatomic ion transport
H	0006816	biological_process	calcium ion transport
H	0007528	biological_process	neuromuscular junction development
H	0009986	cellular_component	cell surface
H	0016020	cellular_component	membrane
H	0016247	molecular_function	channel regulator activity
H	0019226	biological_process	transmission of nerve impulse
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0034702	cellular_component	monoatomic ion channel complex
H	0035255	molecular_function	ionotropic glutamate receptor binding
H	0036477	cellular_component	somatodendritic compartment
H	0042391	biological_process	regulation of membrane potential
H	0043005	cellular_component	neuron projection
H	0044300	cellular_component	cerebellar mossy fiber
H	0045202	cellular_component	synapse
H	0050877	biological_process	nervous system process
H	0051592	biological_process	response to calcium ion
H	0051899	biological_process	membrane depolarization
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0060081	biological_process	membrane hyperpolarization
H	0060082	biological_process	eye blink reflex
H	0070588	biological_process	calcium ion transmembrane transport
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
H	0098839	cellular_component	postsynaptic density membrane
H	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
H	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
H	2000311	biological_process	regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	160
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	60
Details	Intramembrane: {"description":"Helical; Pore-forming"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Intramembrane: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=M4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)