9B4M

Filament of Tau in complex with D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0001774	biological_process	microglial cell activation
A	0003677	molecular_function	DNA binding
A	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006974	biological_process	DNA damage response
A	0007267	biological_process	cell-cell signaling
A	0007613	biological_process	memory
A	0008017	molecular_function	microtubule binding
A	0010288	biological_process	response to lead ion
A	0010506	biological_process	regulation of autophagy
A	0010629	biological_process	negative regulation of gene expression
A	0010917	biological_process	negative regulation of mitochondrial membrane potential
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016072	biological_process	rRNA metabolic process
A	0017124	molecular_function	SH3 domain binding
A	0019896	biological_process	axonal transport of mitochondrion
A	0019899	molecular_function	enzyme binding
A	0019901	molecular_function	protein kinase binding
A	0021954	biological_process	central nervous system neuron development
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0030673	cellular_component	axolemma
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031110	biological_process	regulation of microtubule polymerization or depolymerization
A	0031113	biological_process	regulation of microtubule polymerization
A	0031116	biological_process	positive regulation of microtubule polymerization
A	0031122	biological_process	cytoplasmic microtubule organization
A	0031175	biological_process	neuron projection development
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0033044	biological_process	regulation of chromosome organization
A	0034063	biological_process	stress granule assembly
A	0034185	molecular_function	apolipoprotein binding
A	0034399	cellular_component	nuclear periphery
A	0034452	molecular_function	dynactin binding
A	0034605	biological_process	cellular response to heat
A	0034614	biological_process	cellular response to reactive oxygen species
A	0035091	molecular_function	phosphatidylinositol binding
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0036477	cellular_component	somatodendritic compartment
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043197	cellular_component	dendritic spine
A	0043565	molecular_function	sequence-specific DNA binding
A	0044297	cellular_component	cell body
A	0044304	cellular_component	main axon
A	0045121	cellular_component	membrane raft
A	0045298	cellular_component	tubulin complex
A	0045773	biological_process	positive regulation of axon extension
A	0046785	biological_process	microtubule polymerization
A	0048143	biological_process	astrocyte activation
A	0048167	biological_process	regulation of synaptic plasticity
A	0048312	biological_process	intracellular distribution of mitochondria
A	0048699	biological_process	generation of neurons
A	0050808	biological_process	synapse organization
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0051087	molecular_function	protein-folding chaperone binding
A	0051258	biological_process	protein polymerization
A	0051721	molecular_function	protein phosphatase 2A binding
A	0051879	molecular_function	Hsp90 protein binding
A	0061564	biological_process	axon development
A	0070507	biological_process	regulation of microtubule cytoskeleton organization
A	0071813	molecular_function	lipoprotein particle binding
A	0072386	biological_process	plus-end-directed organelle transport along microtubule
A	0090140	biological_process	regulation of mitochondrial fission
A	0090258	biological_process	negative regulation of mitochondrial fission
A	0097386	cellular_component	glial cell projection
A	0097418	cellular_component	neurofibrillary tangle
A	0097435	biological_process	supramolecular fiber organization
A	0098930	biological_process	axonal transport
A	0099077	molecular_function	histone-dependent DNA binding
A	0099609	molecular_function	microtubule lateral binding
A	1900034	biological_process	regulation of cellular response to heat
A	1900452	biological_process	regulation of long-term synaptic depression
A	1902474	biological_process	positive regulation of protein localization to synapse
A	1902936	molecular_function	phosphatidylinositol bisphosphate binding
A	1902988	biological_process	neurofibrillary tangle assembly
A	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
A	1903829	biological_process	positive regulation of protein localization
A	1904115	cellular_component	axon cytoplasm
A	1904428	biological_process	negative regulation of tubulin deacetylation
A	1990000	biological_process	amyloid fibril formation
A	1990090	biological_process	cellular response to nerve growth factor stimulus
A	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
B	0000226	biological_process	microtubule cytoskeleton organization
B	0001774	biological_process	microglial cell activation
B	0003677	molecular_function	DNA binding
B	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0003723	molecular_function	RNA binding
B	0003779	molecular_function	actin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0006974	biological_process	DNA damage response
B	0007267	biological_process	cell-cell signaling
B	0007613	biological_process	memory
B	0008017	molecular_function	microtubule binding
B	0010288	biological_process	response to lead ion
B	0010506	biological_process	regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0010917	biological_process	negative regulation of mitochondrial membrane potential
B	0015630	cellular_component	microtubule cytoskeleton
B	0016020	cellular_component	membrane
B	0016072	biological_process	rRNA metabolic process
B	0017124	molecular_function	SH3 domain binding
B	0019896	biological_process	axonal transport of mitochondrion
B	0019899	molecular_function	enzyme binding
B	0019901	molecular_function	protein kinase binding
B	0021954	biological_process	central nervous system neuron development
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0030673	cellular_component	axolemma
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031110	biological_process	regulation of microtubule polymerization or depolymerization
B	0031113	biological_process	regulation of microtubule polymerization
B	0031116	biological_process	positive regulation of microtubule polymerization
B	0031122	biological_process	cytoplasmic microtubule organization
B	0031175	biological_process	neuron projection development
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0033044	biological_process	regulation of chromosome organization
B	0034063	biological_process	stress granule assembly
B	0034185	molecular_function	apolipoprotein binding
B	0034399	cellular_component	nuclear periphery
B	0034452	molecular_function	dynactin binding
B	0034605	biological_process	cellular response to heat
B	0034614	biological_process	cellular response to reactive oxygen species
B	0035091	molecular_function	phosphatidylinositol binding
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0036477	cellular_component	somatodendritic compartment
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043197	cellular_component	dendritic spine
B	0043565	molecular_function	sequence-specific DNA binding
B	0044297	cellular_component	cell body
B	0044304	cellular_component	main axon
B	0045121	cellular_component	membrane raft
B	0045298	cellular_component	tubulin complex
B	0045773	biological_process	positive regulation of axon extension
B	0046785	biological_process	microtubule polymerization
B	0048143	biological_process	astrocyte activation
B	0048167	biological_process	regulation of synaptic plasticity
B	0048312	biological_process	intracellular distribution of mitochondria
B	0048699	biological_process	generation of neurons
B	0050808	biological_process	synapse organization
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051087	molecular_function	protein-folding chaperone binding
B	0051258	biological_process	protein polymerization
B	0051721	molecular_function	protein phosphatase 2A binding
B	0051879	molecular_function	Hsp90 protein binding
B	0061564	biological_process	axon development
B	0070507	biological_process	regulation of microtubule cytoskeleton organization
B	0071813	molecular_function	lipoprotein particle binding
B	0072386	biological_process	plus-end-directed organelle transport along microtubule
B	0090140	biological_process	regulation of mitochondrial fission
B	0090258	biological_process	negative regulation of mitochondrial fission
B	0097386	cellular_component	glial cell projection
B	0097418	cellular_component	neurofibrillary tangle
B	0097435	biological_process	supramolecular fiber organization
B	0098930	biological_process	axonal transport
B	0099077	molecular_function	histone-dependent DNA binding
B	0099609	molecular_function	microtubule lateral binding
B	1900034	biological_process	regulation of cellular response to heat
B	1900452	biological_process	regulation of long-term synaptic depression
B	1902474	biological_process	positive regulation of protein localization to synapse
B	1902936	molecular_function	phosphatidylinositol bisphosphate binding
B	1902988	biological_process	neurofibrillary tangle assembly
B	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
B	1903829	biological_process	positive regulation of protein localization
B	1904115	cellular_component	axon cytoplasm
B	1904428	biological_process	negative regulation of tubulin deacetylation
B	1990000	biological_process	amyloid fibril formation
B	1990090	biological_process	cellular response to nerve growth factor stimulus
B	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
C	0000226	biological_process	microtubule cytoskeleton organization
C	0001774	biological_process	microglial cell activation
C	0003677	molecular_function	DNA binding
C	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0006974	biological_process	DNA damage response
C	0007267	biological_process	cell-cell signaling
C	0007613	biological_process	memory
C	0008017	molecular_function	microtubule binding
C	0010288	biological_process	response to lead ion
C	0010506	biological_process	regulation of autophagy
C	0010629	biological_process	negative regulation of gene expression
C	0010917	biological_process	negative regulation of mitochondrial membrane potential
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016072	biological_process	rRNA metabolic process
C	0017124	molecular_function	SH3 domain binding
C	0019896	biological_process	axonal transport of mitochondrion
C	0019899	molecular_function	enzyme binding
C	0019901	molecular_function	protein kinase binding
C	0021954	biological_process	central nervous system neuron development
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0030673	cellular_component	axolemma
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031110	biological_process	regulation of microtubule polymerization or depolymerization
C	0031113	biological_process	regulation of microtubule polymerization
C	0031116	biological_process	positive regulation of microtubule polymerization
C	0031122	biological_process	cytoplasmic microtubule organization
C	0031175	biological_process	neuron projection development
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0033044	biological_process	regulation of chromosome organization
C	0034063	biological_process	stress granule assembly
C	0034185	molecular_function	apolipoprotein binding
C	0034399	cellular_component	nuclear periphery
C	0034452	molecular_function	dynactin binding
C	0034605	biological_process	cellular response to heat
C	0034614	biological_process	cellular response to reactive oxygen species
C	0035091	molecular_function	phosphatidylinositol binding
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0036477	cellular_component	somatodendritic compartment
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043197	cellular_component	dendritic spine
C	0043565	molecular_function	sequence-specific DNA binding
C	0044297	cellular_component	cell body
C	0044304	cellular_component	main axon
C	0045121	cellular_component	membrane raft
C	0045298	cellular_component	tubulin complex
C	0045773	biological_process	positive regulation of axon extension
C	0046785	biological_process	microtubule polymerization
C	0048143	biological_process	astrocyte activation
C	0048167	biological_process	regulation of synaptic plasticity
C	0048312	biological_process	intracellular distribution of mitochondria
C	0048699	biological_process	generation of neurons
C	0050808	biological_process	synapse organization
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051087	molecular_function	protein-folding chaperone binding
C	0051258	biological_process	protein polymerization
C	0051721	molecular_function	protein phosphatase 2A binding
C	0051879	molecular_function	Hsp90 protein binding
C	0061564	biological_process	axon development
C	0070507	biological_process	regulation of microtubule cytoskeleton organization
C	0071813	molecular_function	lipoprotein particle binding
C	0072386	biological_process	plus-end-directed organelle transport along microtubule
C	0090140	biological_process	regulation of mitochondrial fission
C	0090258	biological_process	negative regulation of mitochondrial fission
C	0097386	cellular_component	glial cell projection
C	0097418	cellular_component	neurofibrillary tangle
C	0097435	biological_process	supramolecular fiber organization
C	0098930	biological_process	axonal transport
C	0099077	molecular_function	histone-dependent DNA binding
C	0099609	molecular_function	microtubule lateral binding
C	1900034	biological_process	regulation of cellular response to heat
C	1900452	biological_process	regulation of long-term synaptic depression
C	1902474	biological_process	positive regulation of protein localization to synapse
C	1902936	molecular_function	phosphatidylinositol bisphosphate binding
C	1902988	biological_process	neurofibrillary tangle assembly
C	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
C	1903829	biological_process	positive regulation of protein localization
C	1904115	cellular_component	axon cytoplasm
C	1904428	biological_process	negative regulation of tubulin deacetylation
C	1990000	biological_process	amyloid fibril formation
C	1990090	biological_process	cellular response to nerve growth factor stimulus
C	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
D	0000226	biological_process	microtubule cytoskeleton organization
D	0001774	biological_process	microglial cell activation
D	0003677	molecular_function	DNA binding
D	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0003723	molecular_function	RNA binding
D	0003779	molecular_function	actin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005886	cellular_component	plasma membrane
D	0006974	biological_process	DNA damage response
D	0007267	biological_process	cell-cell signaling
D	0007613	biological_process	memory
D	0008017	molecular_function	microtubule binding
D	0010288	biological_process	response to lead ion
D	0010506	biological_process	regulation of autophagy
D	0010629	biological_process	negative regulation of gene expression
D	0010917	biological_process	negative regulation of mitochondrial membrane potential
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016072	biological_process	rRNA metabolic process
D	0017124	molecular_function	SH3 domain binding
D	0019896	biological_process	axonal transport of mitochondrion
D	0019899	molecular_function	enzyme binding
D	0019901	molecular_function	protein kinase binding
D	0021954	biological_process	central nervous system neuron development
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0030673	cellular_component	axolemma
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031110	biological_process	regulation of microtubule polymerization or depolymerization
D	0031113	biological_process	regulation of microtubule polymerization
D	0031116	biological_process	positive regulation of microtubule polymerization
D	0031122	biological_process	cytoplasmic microtubule organization
D	0031175	biological_process	neuron projection development
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0033044	biological_process	regulation of chromosome organization
D	0034063	biological_process	stress granule assembly
D	0034185	molecular_function	apolipoprotein binding
D	0034399	cellular_component	nuclear periphery
D	0034452	molecular_function	dynactin binding
D	0034605	biological_process	cellular response to heat
D	0034614	biological_process	cellular response to reactive oxygen species
D	0035091	molecular_function	phosphatidylinositol binding
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0036477	cellular_component	somatodendritic compartment
D	0042802	molecular_function	identical protein binding
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0043565	molecular_function	sequence-specific DNA binding
D	0044297	cellular_component	cell body
D	0044304	cellular_component	main axon
D	0045121	cellular_component	membrane raft
D	0045298	cellular_component	tubulin complex
D	0045773	biological_process	positive regulation of axon extension
D	0046785	biological_process	microtubule polymerization
D	0048143	biological_process	astrocyte activation
D	0048167	biological_process	regulation of synaptic plasticity
D	0048312	biological_process	intracellular distribution of mitochondria
D	0048699	biological_process	generation of neurons
D	0050808	biological_process	synapse organization
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0051087	molecular_function	protein-folding chaperone binding
D	0051258	biological_process	protein polymerization
D	0051721	molecular_function	protein phosphatase 2A binding
D	0051879	molecular_function	Hsp90 protein binding
D	0061564	biological_process	axon development
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0071813	molecular_function	lipoprotein particle binding
D	0072386	biological_process	plus-end-directed organelle transport along microtubule
D	0090140	biological_process	regulation of mitochondrial fission
D	0090258	biological_process	negative regulation of mitochondrial fission
D	0097386	cellular_component	glial cell projection
D	0097418	cellular_component	neurofibrillary tangle
D	0097435	biological_process	supramolecular fiber organization
D	0098930	biological_process	axonal transport
D	0099077	molecular_function	histone-dependent DNA binding
D	0099609	molecular_function	microtubule lateral binding
D	1900034	biological_process	regulation of cellular response to heat
D	1900452	biological_process	regulation of long-term synaptic depression
D	1902474	biological_process	positive regulation of protein localization to synapse
D	1902936	molecular_function	phosphatidylinositol bisphosphate binding
D	1902988	biological_process	neurofibrillary tangle assembly
D	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
D	1903829	biological_process	positive regulation of protein localization
D	1904115	cellular_component	axon cytoplasm
D	1904428	biological_process	negative regulation of tubulin deacetylation
D	1990000	biological_process	amyloid fibril formation
D	1990090	biological_process	cellular response to nerve growth factor stimulus
D	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
E	0000226	biological_process	microtubule cytoskeleton organization
E	0001774	biological_process	microglial cell activation
E	0003677	molecular_function	DNA binding
E	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005886	cellular_component	plasma membrane
E	0006974	biological_process	DNA damage response
E	0007267	biological_process	cell-cell signaling
E	0007613	biological_process	memory
E	0008017	molecular_function	microtubule binding
E	0010288	biological_process	response to lead ion
E	0010506	biological_process	regulation of autophagy
E	0010629	biological_process	negative regulation of gene expression
E	0010917	biological_process	negative regulation of mitochondrial membrane potential
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0016072	biological_process	rRNA metabolic process
E	0017124	molecular_function	SH3 domain binding
E	0019896	biological_process	axonal transport of mitochondrion
E	0019899	molecular_function	enzyme binding
E	0019901	molecular_function	protein kinase binding
E	0021954	biological_process	central nervous system neuron development
E	0030424	cellular_component	axon
E	0030425	cellular_component	dendrite
E	0030426	cellular_component	growth cone
E	0030673	cellular_component	axolemma
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization
E	0031113	biological_process	regulation of microtubule polymerization
E	0031116	biological_process	positive regulation of microtubule polymerization
E	0031122	biological_process	cytoplasmic microtubule organization
E	0031175	biological_process	neuron projection development
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0033044	biological_process	regulation of chromosome organization
E	0034063	biological_process	stress granule assembly
E	0034185	molecular_function	apolipoprotein binding
E	0034399	cellular_component	nuclear periphery
E	0034452	molecular_function	dynactin binding
E	0034605	biological_process	cellular response to heat
E	0034614	biological_process	cellular response to reactive oxygen species
E	0035091	molecular_function	phosphatidylinositol binding
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0036477	cellular_component	somatodendritic compartment
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043197	cellular_component	dendritic spine
E	0043565	molecular_function	sequence-specific DNA binding
E	0044297	cellular_component	cell body
E	0044304	cellular_component	main axon
E	0045121	cellular_component	membrane raft
E	0045298	cellular_component	tubulin complex
E	0045773	biological_process	positive regulation of axon extension
E	0046785	biological_process	microtubule polymerization
E	0048143	biological_process	astrocyte activation
E	0048167	biological_process	regulation of synaptic plasticity
E	0048312	biological_process	intracellular distribution of mitochondria
E	0048699	biological_process	generation of neurons
E	0050808	biological_process	synapse organization
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051087	molecular_function	protein-folding chaperone binding
E	0051258	biological_process	protein polymerization
E	0051721	molecular_function	protein phosphatase 2A binding
E	0051879	molecular_function	Hsp90 protein binding
E	0061564	biological_process	axon development
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0071813	molecular_function	lipoprotein particle binding
E	0072386	biological_process	plus-end-directed organelle transport along microtubule
E	0090140	biological_process	regulation of mitochondrial fission
E	0090258	biological_process	negative regulation of mitochondrial fission
E	0097386	cellular_component	glial cell projection
E	0097418	cellular_component	neurofibrillary tangle
E	0097435	biological_process	supramolecular fiber organization
E	0098930	biological_process	axonal transport
E	0099077	molecular_function	histone-dependent DNA binding
E	0099609	molecular_function	microtubule lateral binding
E	1900034	biological_process	regulation of cellular response to heat
E	1900452	biological_process	regulation of long-term synaptic depression
E	1902474	biological_process	positive regulation of protein localization to synapse
E	1902936	molecular_function	phosphatidylinositol bisphosphate binding
E	1902988	biological_process	neurofibrillary tangle assembly
E	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
E	1903829	biological_process	positive regulation of protein localization
E	1904115	cellular_component	axon cytoplasm
E	1904428	biological_process	negative regulation of tubulin deacetylation
E	1990000	biological_process	amyloid fibril formation
E	1990090	biological_process	cellular response to nerve growth factor stimulus
E	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
F	0000226	biological_process	microtubule cytoskeleton organization
F	0001774	biological_process	microglial cell activation
F	0003677	molecular_function	DNA binding
F	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0003723	molecular_function	RNA binding
F	0003779	molecular_function	actin binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005886	cellular_component	plasma membrane
F	0006974	biological_process	DNA damage response
F	0007267	biological_process	cell-cell signaling
F	0007613	biological_process	memory
F	0008017	molecular_function	microtubule binding
F	0010288	biological_process	response to lead ion
F	0010506	biological_process	regulation of autophagy
F	0010629	biological_process	negative regulation of gene expression
F	0010917	biological_process	negative regulation of mitochondrial membrane potential
F	0015630	cellular_component	microtubule cytoskeleton
F	0016020	cellular_component	membrane
F	0016072	biological_process	rRNA metabolic process
F	0017124	molecular_function	SH3 domain binding
F	0019896	biological_process	axonal transport of mitochondrion
F	0019899	molecular_function	enzyme binding
F	0019901	molecular_function	protein kinase binding
F	0021954	biological_process	central nervous system neuron development
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0030426	cellular_component	growth cone
F	0030673	cellular_component	axolemma
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0031110	biological_process	regulation of microtubule polymerization or depolymerization
F	0031113	biological_process	regulation of microtubule polymerization
F	0031116	biological_process	positive regulation of microtubule polymerization
F	0031122	biological_process	cytoplasmic microtubule organization
F	0031175	biological_process	neuron projection development
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0033044	biological_process	regulation of chromosome organization
F	0034063	biological_process	stress granule assembly
F	0034185	molecular_function	apolipoprotein binding
F	0034399	cellular_component	nuclear periphery
F	0034452	molecular_function	dynactin binding
F	0034605	biological_process	cellular response to heat
F	0034614	biological_process	cellular response to reactive oxygen species
F	0035091	molecular_function	phosphatidylinositol binding
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0036477	cellular_component	somatodendritic compartment
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0043005	cellular_component	neuron projection
F	0043025	cellular_component	neuronal cell body
F	0043197	cellular_component	dendritic spine
F	0043565	molecular_function	sequence-specific DNA binding
F	0044297	cellular_component	cell body
F	0044304	cellular_component	main axon
F	0045121	cellular_component	membrane raft
F	0045298	cellular_component	tubulin complex
F	0045773	biological_process	positive regulation of axon extension
F	0046785	biological_process	microtubule polymerization
F	0048143	biological_process	astrocyte activation
F	0048167	biological_process	regulation of synaptic plasticity
F	0048312	biological_process	intracellular distribution of mitochondria
F	0048699	biological_process	generation of neurons
F	0050808	biological_process	synapse organization
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051087	molecular_function	protein-folding chaperone binding
F	0051258	biological_process	protein polymerization
F	0051721	molecular_function	protein phosphatase 2A binding
F	0051879	molecular_function	Hsp90 protein binding
F	0061564	biological_process	axon development
F	0070507	biological_process	regulation of microtubule cytoskeleton organization
F	0071813	molecular_function	lipoprotein particle binding
F	0072386	biological_process	plus-end-directed organelle transport along microtubule
F	0090140	biological_process	regulation of mitochondrial fission
F	0090258	biological_process	negative regulation of mitochondrial fission
F	0097386	cellular_component	glial cell projection
F	0097418	cellular_component	neurofibrillary tangle
F	0097435	biological_process	supramolecular fiber organization
F	0098930	biological_process	axonal transport
F	0099077	molecular_function	histone-dependent DNA binding
F	0099609	molecular_function	microtubule lateral binding
F	1900034	biological_process	regulation of cellular response to heat
F	1900452	biological_process	regulation of long-term synaptic depression
F	1902474	biological_process	positive regulation of protein localization to synapse
F	1902936	molecular_function	phosphatidylinositol bisphosphate binding
F	1902988	biological_process	neurofibrillary tangle assembly
F	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
F	1903829	biological_process	positive regulation of protein localization
F	1904115	cellular_component	axon cytoplasm
F	1904428	biological_process	negative regulation of tubulin deacetylation
F	1990000	biological_process	amyloid fibril formation
F	1990090	biological_process	cellular response to nerve growth factor stimulus
F	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
G	0000226	biological_process	microtubule cytoskeleton organization
G	0001774	biological_process	microglial cell activation
G	0003677	molecular_function	DNA binding
G	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005886	cellular_component	plasma membrane
G	0006974	biological_process	DNA damage response
G	0007267	biological_process	cell-cell signaling
G	0007613	biological_process	memory
G	0008017	molecular_function	microtubule binding
G	0010288	biological_process	response to lead ion
G	0010506	biological_process	regulation of autophagy
G	0010629	biological_process	negative regulation of gene expression
G	0010917	biological_process	negative regulation of mitochondrial membrane potential
G	0015630	cellular_component	microtubule cytoskeleton
G	0016020	cellular_component	membrane
G	0016072	biological_process	rRNA metabolic process
G	0017124	molecular_function	SH3 domain binding
G	0019896	biological_process	axonal transport of mitochondrion
G	0019899	molecular_function	enzyme binding
G	0019901	molecular_function	protein kinase binding
G	0021954	biological_process	central nervous system neuron development
G	0030424	cellular_component	axon
G	0030425	cellular_component	dendrite
G	0030426	cellular_component	growth cone
G	0030673	cellular_component	axolemma
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031110	biological_process	regulation of microtubule polymerization or depolymerization
G	0031113	biological_process	regulation of microtubule polymerization
G	0031116	biological_process	positive regulation of microtubule polymerization
G	0031122	biological_process	cytoplasmic microtubule organization
G	0031175	biological_process	neuron projection development
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0033044	biological_process	regulation of chromosome organization
G	0034063	biological_process	stress granule assembly
G	0034185	molecular_function	apolipoprotein binding
G	0034399	cellular_component	nuclear periphery
G	0034452	molecular_function	dynactin binding
G	0034605	biological_process	cellular response to heat
G	0034614	biological_process	cellular response to reactive oxygen species
G	0035091	molecular_function	phosphatidylinositol binding
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0036477	cellular_component	somatodendritic compartment
G	0042802	molecular_function	identical protein binding
G	0042995	cellular_component	cell projection
G	0043005	cellular_component	neuron projection
G	0043025	cellular_component	neuronal cell body
G	0043197	cellular_component	dendritic spine
G	0043565	molecular_function	sequence-specific DNA binding
G	0044297	cellular_component	cell body
G	0044304	cellular_component	main axon
G	0045121	cellular_component	membrane raft
G	0045298	cellular_component	tubulin complex
G	0045773	biological_process	positive regulation of axon extension
G	0046785	biological_process	microtubule polymerization
G	0048143	biological_process	astrocyte activation
G	0048167	biological_process	regulation of synaptic plasticity
G	0048312	biological_process	intracellular distribution of mitochondria
G	0048699	biological_process	generation of neurons
G	0050808	biological_process	synapse organization
G	0050848	biological_process	regulation of calcium-mediated signaling
G	0051087	molecular_function	protein-folding chaperone binding
G	0051258	biological_process	protein polymerization
G	0051721	molecular_function	protein phosphatase 2A binding
G	0051879	molecular_function	Hsp90 protein binding
G	0061564	biological_process	axon development
G	0070507	biological_process	regulation of microtubule cytoskeleton organization
G	0071813	molecular_function	lipoprotein particle binding
G	0072386	biological_process	plus-end-directed organelle transport along microtubule
G	0090140	biological_process	regulation of mitochondrial fission
G	0090258	biological_process	negative regulation of mitochondrial fission
G	0097386	cellular_component	glial cell projection
G	0097418	cellular_component	neurofibrillary tangle
G	0097435	biological_process	supramolecular fiber organization
G	0098930	biological_process	axonal transport
G	0099077	molecular_function	histone-dependent DNA binding
G	0099609	molecular_function	microtubule lateral binding
G	1900034	biological_process	regulation of cellular response to heat
G	1900452	biological_process	regulation of long-term synaptic depression
G	1902474	biological_process	positive regulation of protein localization to synapse
G	1902936	molecular_function	phosphatidylinositol bisphosphate binding
G	1902988	biological_process	neurofibrillary tangle assembly
G	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
G	1903829	biological_process	positive regulation of protein localization
G	1904115	cellular_component	axon cytoplasm
G	1904428	biological_process	negative regulation of tubulin deacetylation
G	1990000	biological_process	amyloid fibril formation
G	1990090	biological_process	cellular response to nerve growth factor stimulus
G	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
H	0000226	biological_process	microtubule cytoskeleton organization
H	0001774	biological_process	microglial cell activation
H	0003677	molecular_function	DNA binding
H	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
H	0003690	molecular_function	double-stranded DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003723	molecular_function	RNA binding
H	0003779	molecular_function	actin binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005886	cellular_component	plasma membrane
H	0006974	biological_process	DNA damage response
H	0007267	biological_process	cell-cell signaling
H	0007613	biological_process	memory
H	0008017	molecular_function	microtubule binding
H	0010288	biological_process	response to lead ion
H	0010506	biological_process	regulation of autophagy
H	0010629	biological_process	negative regulation of gene expression
H	0010917	biological_process	negative regulation of mitochondrial membrane potential
H	0015630	cellular_component	microtubule cytoskeleton
H	0016020	cellular_component	membrane
H	0016072	biological_process	rRNA metabolic process
H	0017124	molecular_function	SH3 domain binding
H	0019896	biological_process	axonal transport of mitochondrion
H	0019899	molecular_function	enzyme binding
H	0019901	molecular_function	protein kinase binding
H	0021954	biological_process	central nervous system neuron development
H	0030424	cellular_component	axon
H	0030425	cellular_component	dendrite
H	0030426	cellular_component	growth cone
H	0030673	cellular_component	axolemma
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0031110	biological_process	regulation of microtubule polymerization or depolymerization
H	0031113	biological_process	regulation of microtubule polymerization
H	0031116	biological_process	positive regulation of microtubule polymerization
H	0031122	biological_process	cytoplasmic microtubule organization
H	0031175	biological_process	neuron projection development
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0033044	biological_process	regulation of chromosome organization
H	0034063	biological_process	stress granule assembly
H	0034185	molecular_function	apolipoprotein binding
H	0034399	cellular_component	nuclear periphery
H	0034452	molecular_function	dynactin binding
H	0034605	biological_process	cellular response to heat
H	0034614	biological_process	cellular response to reactive oxygen species
H	0035091	molecular_function	phosphatidylinositol binding
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0036477	cellular_component	somatodendritic compartment
H	0042802	molecular_function	identical protein binding
H	0042995	cellular_component	cell projection
H	0043005	cellular_component	neuron projection
H	0043025	cellular_component	neuronal cell body
H	0043197	cellular_component	dendritic spine
H	0043565	molecular_function	sequence-specific DNA binding
H	0044297	cellular_component	cell body
H	0044304	cellular_component	main axon
H	0045121	cellular_component	membrane raft
H	0045298	cellular_component	tubulin complex
H	0045773	biological_process	positive regulation of axon extension
H	0046785	biological_process	microtubule polymerization
H	0048143	biological_process	astrocyte activation
H	0048167	biological_process	regulation of synaptic plasticity
H	0048312	biological_process	intracellular distribution of mitochondria
H	0048699	biological_process	generation of neurons
H	0050808	biological_process	synapse organization
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051087	molecular_function	protein-folding chaperone binding
H	0051258	biological_process	protein polymerization
H	0051721	molecular_function	protein phosphatase 2A binding
H	0051879	molecular_function	Hsp90 protein binding
H	0061564	biological_process	axon development
H	0070507	biological_process	regulation of microtubule cytoskeleton organization
H	0071813	molecular_function	lipoprotein particle binding
H	0072386	biological_process	plus-end-directed organelle transport along microtubule
H	0090140	biological_process	regulation of mitochondrial fission
H	0090258	biological_process	negative regulation of mitochondrial fission
H	0097386	cellular_component	glial cell projection
H	0097418	cellular_component	neurofibrillary tangle
H	0097435	biological_process	supramolecular fiber organization
H	0098930	biological_process	axonal transport
H	0099077	molecular_function	histone-dependent DNA binding
H	0099609	molecular_function	microtubule lateral binding
H	1900034	biological_process	regulation of cellular response to heat
H	1900452	biological_process	regulation of long-term synaptic depression
H	1902474	biological_process	positive regulation of protein localization to synapse
H	1902936	molecular_function	phosphatidylinositol bisphosphate binding
H	1902988	biological_process	neurofibrillary tangle assembly
H	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
H	1903829	biological_process	positive regulation of protein localization
H	1904115	cellular_component	axon cytoplasm
H	1904428	biological_process	negative regulation of tubulin deacetylation
H	1990000	biological_process	amyloid fibril formation
H	1990090	biological_process	cellular response to nerve growth factor stimulus
H	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
I	0000226	biological_process	microtubule cytoskeleton organization
I	0001774	biological_process	microglial cell activation
I	0003677	molecular_function	DNA binding
I	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
I	0003690	molecular_function	double-stranded DNA binding
I	0003697	molecular_function	single-stranded DNA binding
I	0003723	molecular_function	RNA binding
I	0003779	molecular_function	actin binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005886	cellular_component	plasma membrane
I	0006974	biological_process	DNA damage response
I	0007267	biological_process	cell-cell signaling
I	0007613	biological_process	memory
I	0008017	molecular_function	microtubule binding
I	0010288	biological_process	response to lead ion
I	0010506	biological_process	regulation of autophagy
I	0010629	biological_process	negative regulation of gene expression
I	0010917	biological_process	negative regulation of mitochondrial membrane potential
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0016072	biological_process	rRNA metabolic process
I	0017124	molecular_function	SH3 domain binding
I	0019896	biological_process	axonal transport of mitochondrion
I	0019899	molecular_function	enzyme binding
I	0019901	molecular_function	protein kinase binding
I	0021954	biological_process	central nervous system neuron development
I	0030424	cellular_component	axon
I	0030425	cellular_component	dendrite
I	0030426	cellular_component	growth cone
I	0030673	cellular_component	axolemma
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031110	biological_process	regulation of microtubule polymerization or depolymerization
I	0031113	biological_process	regulation of microtubule polymerization
I	0031116	biological_process	positive regulation of microtubule polymerization
I	0031122	biological_process	cytoplasmic microtubule organization
I	0031175	biological_process	neuron projection development
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0033044	biological_process	regulation of chromosome organization
I	0034063	biological_process	stress granule assembly
I	0034185	molecular_function	apolipoprotein binding
I	0034399	cellular_component	nuclear periphery
I	0034452	molecular_function	dynactin binding
I	0034605	biological_process	cellular response to heat
I	0034614	biological_process	cellular response to reactive oxygen species
I	0035091	molecular_function	phosphatidylinositol binding
I	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
I	0036477	cellular_component	somatodendritic compartment
I	0042802	molecular_function	identical protein binding
I	0042995	cellular_component	cell projection
I	0043005	cellular_component	neuron projection
I	0043025	cellular_component	neuronal cell body
I	0043197	cellular_component	dendritic spine
I	0043565	molecular_function	sequence-specific DNA binding
I	0044297	cellular_component	cell body
I	0044304	cellular_component	main axon
I	0045121	cellular_component	membrane raft
I	0045298	cellular_component	tubulin complex
I	0045773	biological_process	positive regulation of axon extension
I	0046785	biological_process	microtubule polymerization
I	0048143	biological_process	astrocyte activation
I	0048167	biological_process	regulation of synaptic plasticity
I	0048312	biological_process	intracellular distribution of mitochondria
I	0048699	biological_process	generation of neurons
I	0050808	biological_process	synapse organization
I	0050848	biological_process	regulation of calcium-mediated signaling
I	0051087	molecular_function	protein-folding chaperone binding
I	0051258	biological_process	protein polymerization
I	0051721	molecular_function	protein phosphatase 2A binding
I	0051879	molecular_function	Hsp90 protein binding
I	0061564	biological_process	axon development
I	0070507	biological_process	regulation of microtubule cytoskeleton organization
I	0071813	molecular_function	lipoprotein particle binding
I	0072386	biological_process	plus-end-directed organelle transport along microtubule
I	0090140	biological_process	regulation of mitochondrial fission
I	0090258	biological_process	negative regulation of mitochondrial fission
I	0097386	cellular_component	glial cell projection
I	0097418	cellular_component	neurofibrillary tangle
I	0097435	biological_process	supramolecular fiber organization
I	0098930	biological_process	axonal transport
I	0099077	molecular_function	histone-dependent DNA binding
I	0099609	molecular_function	microtubule lateral binding
I	1900034	biological_process	regulation of cellular response to heat
I	1900452	biological_process	regulation of long-term synaptic depression
I	1902474	biological_process	positive regulation of protein localization to synapse
I	1902936	molecular_function	phosphatidylinositol bisphosphate binding
I	1902988	biological_process	neurofibrillary tangle assembly
I	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
I	1903829	biological_process	positive regulation of protein localization
I	1904115	cellular_component	axon cytoplasm
I	1904428	biological_process	negative regulation of tubulin deacetylation
I	1990000	biological_process	amyloid fibril formation
I	1990090	biological_process	cellular response to nerve growth factor stimulus
I	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus
J	0000226	biological_process	microtubule cytoskeleton organization
J	0001774	biological_process	microglial cell activation
J	0003677	molecular_function	DNA binding
J	0003680	molecular_function	minor groove of adenine-thymine-rich DNA binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003697	molecular_function	single-stranded DNA binding
J	0003723	molecular_function	RNA binding
J	0003779	molecular_function	actin binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005886	cellular_component	plasma membrane
J	0006974	biological_process	DNA damage response
J	0007267	biological_process	cell-cell signaling
J	0007613	biological_process	memory
J	0008017	molecular_function	microtubule binding
J	0010288	biological_process	response to lead ion
J	0010506	biological_process	regulation of autophagy
J	0010629	biological_process	negative regulation of gene expression
J	0010917	biological_process	negative regulation of mitochondrial membrane potential
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0016072	biological_process	rRNA metabolic process
J	0017124	molecular_function	SH3 domain binding
J	0019896	biological_process	axonal transport of mitochondrion
J	0019899	molecular_function	enzyme binding
J	0019901	molecular_function	protein kinase binding
J	0021954	biological_process	central nervous system neuron development
J	0030424	cellular_component	axon
J	0030425	cellular_component	dendrite
J	0030426	cellular_component	growth cone
J	0030673	cellular_component	axolemma
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031110	biological_process	regulation of microtubule polymerization or depolymerization
J	0031113	biological_process	regulation of microtubule polymerization
J	0031116	biological_process	positive regulation of microtubule polymerization
J	0031122	biological_process	cytoplasmic microtubule organization
J	0031175	biological_process	neuron projection development
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0033044	biological_process	regulation of chromosome organization
J	0034063	biological_process	stress granule assembly
J	0034185	molecular_function	apolipoprotein binding
J	0034399	cellular_component	nuclear periphery
J	0034452	molecular_function	dynactin binding
J	0034605	biological_process	cellular response to heat
J	0034614	biological_process	cellular response to reactive oxygen species
J	0035091	molecular_function	phosphatidylinositol binding
J	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
J	0036477	cellular_component	somatodendritic compartment
J	0042802	molecular_function	identical protein binding
J	0042995	cellular_component	cell projection
J	0043005	cellular_component	neuron projection
J	0043025	cellular_component	neuronal cell body
J	0043197	cellular_component	dendritic spine
J	0043565	molecular_function	sequence-specific DNA binding
J	0044297	cellular_component	cell body
J	0044304	cellular_component	main axon
J	0045121	cellular_component	membrane raft
J	0045298	cellular_component	tubulin complex
J	0045773	biological_process	positive regulation of axon extension
J	0046785	biological_process	microtubule polymerization
J	0048143	biological_process	astrocyte activation
J	0048167	biological_process	regulation of synaptic plasticity
J	0048312	biological_process	intracellular distribution of mitochondria
J	0048699	biological_process	generation of neurons
J	0050808	biological_process	synapse organization
J	0050848	biological_process	regulation of calcium-mediated signaling
J	0051087	molecular_function	protein-folding chaperone binding
J	0051258	biological_process	protein polymerization
J	0051721	molecular_function	protein phosphatase 2A binding
J	0051879	molecular_function	Hsp90 protein binding
J	0061564	biological_process	axon development
J	0070507	biological_process	regulation of microtubule cytoskeleton organization
J	0071813	molecular_function	lipoprotein particle binding
J	0072386	biological_process	plus-end-directed organelle transport along microtubule
J	0090140	biological_process	regulation of mitochondrial fission
J	0090258	biological_process	negative regulation of mitochondrial fission
J	0097386	cellular_component	glial cell projection
J	0097418	cellular_component	neurofibrillary tangle
J	0097435	biological_process	supramolecular fiber organization
J	0098930	biological_process	axonal transport
J	0099077	molecular_function	histone-dependent DNA binding
J	0099609	molecular_function	microtubule lateral binding
J	1900034	biological_process	regulation of cellular response to heat
J	1900452	biological_process	regulation of long-term synaptic depression
J	1902474	biological_process	positive regulation of protein localization to synapse
J	1902936	molecular_function	phosphatidylinositol bisphosphate binding
J	1902988	biological_process	neurofibrillary tangle assembly
J	1903748	biological_process	negative regulation of establishment of protein localization to mitochondrion
J	1903829	biological_process	positive regulation of protein localization
J	1904115	cellular_component	axon cytoplasm
J	1904428	biological_process	negative regulation of tubulin deacetylation
J	1990000	biological_process	amyloid fibril formation
J	1990090	biological_process	cellular response to nerve growth factor stimulus
J	1990416	biological_process	cellular response to brain-derived neurotrophic factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
A	GLY261-GLY273
A	GLY292-GLY304
A	GLY323-GLY335
A	GLY355-GLY367

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	310
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS-293
A	LYS-273
A	LYS-250
A	LYS64
A	LYS74
A	LYS75
A	LYS77
A	LYS148
A	LYS180
A	LYS190
A	LYS224
A	LYS240
A	LYS254
A	LYS257
A	LYS267
A	LYS274
A	LYS290
A	LYS294
A	LYS298
A	LYS311
A	LYS317
A	LYS321
A	LYS331
A	LYS340
A	LYS343
A	LYS370
A	LYS375
A	LYS383
A	LYS385
A	LYS395
A	LYS438
B	LYS-293
B	LYS-273
B	LYS-250
B	LYS64
B	LYS74
B	LYS75
B	LYS77
B	LYS148
B	LYS180
B	LYS190
B	LYS224
B	LYS240
B	LYS254
B	LYS257
B	LYS267
B	LYS274
B	LYS290
B	LYS294
B	LYS298
B	LYS311
B	LYS317
B	LYS321
B	LYS331
B	LYS340
B	LYS343
B	LYS370
B	LYS375
B	LYS383
B	LYS385
B	LYS395
B	LYS438
C	LYS-293
C	LYS-273
C	LYS-250
C	LYS64
C	LYS74
C	LYS75
C	LYS77
C	LYS148
C	LYS180
C	LYS190
C	LYS224
C	LYS240
C	LYS254
C	LYS257
C	LYS267
C	LYS274
C	LYS290
C	LYS294
C	LYS298
C	LYS311
C	LYS317
C	LYS321
C	LYS331
C	LYS340
C	LYS343
C	LYS370
C	LYS375
C	LYS383
C	LYS385
C	LYS395
C	LYS438
D	LYS-293
D	LYS-273
D	LYS-250
D	LYS64
D	LYS74
D	LYS75
D	LYS77
D	LYS148
D	LYS180
D	LYS190
D	LYS224
D	LYS240
D	LYS254
D	LYS257
D	LYS267
D	LYS274
D	LYS290
D	LYS294
D	LYS298
D	LYS311
D	LYS317
D	LYS321
D	LYS331
D	LYS340
D	LYS343
D	LYS370
D	LYS375
D	LYS383
D	LYS385
D	LYS395
D	LYS438
E	LYS-293
E	LYS-273
E	LYS-250
E	LYS64
E	LYS74
E	LYS75
E	LYS77
E	LYS148
E	LYS180
E	LYS190
E	LYS224
E	LYS240
E	LYS254
E	LYS257
E	LYS267
E	LYS274
E	LYS290
E	LYS294
E	LYS298
E	LYS311
E	LYS317
E	LYS321
E	LYS331
E	LYS340
E	LYS343
E	LYS370
E	LYS375
E	LYS383
E	LYS385
E	LYS395
E	LYS438
F	LYS-293
F	LYS-273
F	LYS-250
F	LYS64
F	LYS74
F	LYS75
F	LYS77
F	LYS148
F	LYS180
F	LYS190
F	LYS224
F	LYS240
F	LYS254
F	LYS257
F	LYS267
F	LYS274
F	LYS290
F	LYS294
F	LYS298
F	LYS311
F	LYS317
F	LYS321
F	LYS331
F	LYS340
F	LYS343
F	LYS370
F	LYS375
F	LYS383
F	LYS385
F	LYS395
F	LYS438
G	LYS-293
G	LYS-273
G	LYS-250
G	LYS64
G	LYS74
G	LYS75
G	LYS77
G	LYS148
G	LYS180
G	LYS190
G	LYS224
G	LYS240
G	LYS254
G	LYS257
G	LYS267
G	LYS274
G	LYS290
G	LYS294
G	LYS298
G	LYS311
G	LYS317
G	LYS321
G	LYS331
G	LYS340
G	LYS343
G	LYS370
G	LYS375
G	LYS383
G	LYS385
G	LYS395
G	LYS438
H	LYS-293
H	LYS-273
H	LYS-250
H	LYS64
H	LYS74
H	LYS75
H	LYS77
H	LYS148
H	LYS180
H	LYS190
H	LYS224
H	LYS240
H	LYS254
H	LYS257
H	LYS267
H	LYS274
H	LYS290
H	LYS294
H	LYS298
H	LYS311
H	LYS317
H	LYS321
H	LYS331
H	LYS340
H	LYS343
H	LYS370
H	LYS375
H	LYS383
H	LYS385
H	LYS395
H	LYS438
I	LYS-293
I	LYS-273
I	LYS-250
I	LYS64
I	LYS74
I	LYS75
I	LYS77
I	LYS148
I	LYS180
I	LYS190
I	LYS224
I	LYS240
I	LYS254
I	LYS257
I	LYS267
I	LYS274
I	LYS290
I	LYS294
I	LYS298
I	LYS311
I	LYS317
I	LYS321
I	LYS331
I	LYS340
I	LYS343
I	LYS370
I	LYS375
I	LYS383
I	LYS385
I	LYS395
I	LYS438
J	LYS-293
J	LYS-273
J	LYS-250
J	LYS64
J	LYS74
J	LYS75
J	LYS77
J	LYS148
J	LYS180
J	LYS190
J	LYS224
J	LYS240
J	LYS254
J	LYS257
J	LYS267
J	LYS274
J	LYS290
J	LYS294
J	LYS298
J	LYS311
J	LYS317
J	LYS321
J	LYS331
J	LYS340
J	LYS343
J	LYS370
J	LYS375
J	LYS383
J	LYS385
J	LYS395
J	LYS438

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1512244

Chain	Residue	Details
A	ALA-315
B	ALA-315
C	ALA-315
D	ALA-315
E	ALA-315
F	ALA-315
G	ALA-315
H	ALA-315
I	ALA-315
J	ALA-315

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:14999081

Chain	Residue	Details
A	TYR-299
B	TYR-299
C	TYR-299
D	TYR-299
E	TYR-299
F	TYR-299
G	TYR-299
H	TYR-299
I	TYR-299
J	TYR-299

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	TYR-288
A	TYR394
B	TYR-288
B	TYR394
C	TYR-288
C	TYR394
D	TYR-288
D	TYR394
E	TYR-288
E	TYR394
F	TYR-288
F	TYR394
G	TYR-288
G	TYR394
H	TYR-288
H	TYR394
I	TYR-288
I	TYR394
J	TYR-288
J	TYR394

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19332

Chain	Residue	Details
A	SER-271
A	SER-256
B	SER-271
B	SER-256
C	SER-271
C	SER-256
D	SER-271
D	SER-256
E	SER-271
E	SER-256
F	SER-271
F	SER-256
G	SER-271
G	SER-256
H	SER-271
H	SER-256
I	SER-271
I	SER-256
J	SER-271
J	SER-256

---

site_id	SWS_FT_FI6
Number of Residues	50
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	THR-248
A	THR-206
A	THR169
A	THR175
A	THR403
B	THR-248
B	THR-206
B	THR169
B	THR175
B	THR403
C	THR-248
C	THR-206
C	THR169
C	THR175
C	THR403
D	THR-248
D	THR-206
D	THR169
D	THR175
D	THR403
E	THR-248
E	THR-206
E	THR169
E	THR175
E	THR403
F	THR-248
F	THR-206
F	THR169
F	THR175
F	THR403
G	THR-248
G	THR-206
G	THR169
G	THR175
G	THR403
H	THR-248
H	THR-206
H	THR169
H	THR175
H	THR403
I	THR-248
I	THR-206
I	THR169
I	THR175
I	THR403
J	THR-248
J	THR-206
J	THR169
J	THR175
J	THR403

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P19332

Chain	Residue	Details
A	THR-246
B	THR-246
C	THR-246
D	THR-246
E	THR-246
F	THR-246
G	THR-246
H	THR-246
I	THR-246
J	THR-246

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	MOD_RES: Phosphoserine; by SGK1 => ECO:0000269|PubMed:16982696

Chain	Residue	Details
A	SER-103
B	SER-103
C	SER-103
D	SER-103
E	SER-103
F	SER-103
G	SER-103
H	SER-103
I	SER-103
J	SER-103

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	MOD_RES: Phosphoserine; in PHF-tau => ECO:0000269|PubMed:1899488

Chain	Residue	Details
A	SER79
B	SER79
C	SER79
D	SER79
E	SER79
F	SER79
G	SER79
H	SER79
I	SER79
J	SER79

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	THR153
B	THR153
C	THR153
D	THR153
E	THR153
F	THR153
G	THR153
H	THR153
I	THR153
J	THR153

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	ARG155
A	ARG349
B	ARG155
B	ARG349
C	ARG155
C	ARG349
D	ARG155
D	ARG349
E	ARG155
E	ARG349
F	ARG155
F	ARG349
G	ARG155
G	ARG349
H	ARG155
H	ARG349
I	ARG155
I	ARG349
J	ARG155
J	ARG349

---

site_id	SWS_FT_FI12
Number of Residues	110
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS163
A	LYS281
A	LYS298
A	LYS311
A	LYS317
A	LYS321
A	LYS331
A	LYS343
A	LYS347
A	LYS369
A	LYS385
B	LYS163
B	LYS281
B	LYS298
B	LYS311
B	LYS317
B	LYS321
B	LYS331
B	LYS343
B	LYS347
B	LYS369
B	LYS385
C	LYS163
C	LYS281
C	LYS298
C	LYS311
C	LYS317
C	LYS321
C	LYS331
C	LYS343
C	LYS347
C	LYS369
C	LYS385
D	LYS163
D	LYS281
D	LYS298
D	LYS311
D	LYS317
D	LYS321
D	LYS331
D	LYS343
D	LYS347
D	LYS369
D	LYS385
E	LYS163
E	LYS281
E	LYS298
E	LYS311
E	LYS317
E	LYS321
E	LYS331
E	LYS343
E	LYS347
E	LYS369
E	LYS385
F	LYS163
F	LYS281
F	LYS298
F	LYS311
F	LYS317
F	LYS321
F	LYS331
F	LYS343
F	LYS347
F	LYS369
F	LYS385
G	LYS163
G	LYS281
G	LYS298
G	LYS311
G	LYS317
G	LYS321
G	LYS331
G	LYS343
G	LYS347
G	LYS369
G	LYS385
H	LYS163
H	LYS281
H	LYS298
H	LYS311
H	LYS317
H	LYS321
H	LYS331
H	LYS343
H	LYS347
H	LYS369
H	LYS385
I	LYS163
I	LYS281
I	LYS298
I	LYS311
I	LYS317
I	LYS321
I	LYS331
I	LYS343
I	LYS347
I	LYS369
I	LYS385
J	LYS163
J	LYS281
J	LYS298
J	LYS311
J	LYS317
J	LYS321
J	LYS331
J	LYS343
J	LYS347
J	LYS369
J	LYS385

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	MOD_RES: Deamidated asparagine; in tau and PHF-tau; partial => ECO:0000269|PubMed:1512244

Chain	Residue	Details
A	ASN167
A	ASN279
B	ASN167
B	ASN279
C	ASN167
C	ASN279
D	ASN167
D	ASN279
E	ASN167
E	ASN279
F	ASN167
F	ASN279
G	ASN167
G	ASN279
H	ASN167
H	ASN279
I	ASN167
I	ASN279
J	ASN167
J	ASN279

---

site_id	SWS_FT_FI14
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:15546861

Chain	Residue	Details
A	THR181
B	THR181
C	THR181
D	THR181
E	THR181
F	THR181
G	THR181
H	THR181
I	THR181
J	THR181

---

site_id	SWS_FT_FI15
Number of Residues	30
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	SER185
A	SER191
A	SER195
B	SER185
B	SER191
B	SER195
C	SER185
C	SER191
C	SER195
D	SER185
D	SER191
D	SER195
E	SER185
E	SER191
E	SER195
F	SER185
F	SER191
F	SER195
G	SER185
G	SER191
G	SER195
H	SER185
H	SER191
H	SER195
I	SER185
I	SER191
I	SER195
J	SER185
J	SER191
J	SER195

---

site_id	SWS_FT_FI16
Number of Residues	10
Details	MOD_RES: Phosphotyrosine; by TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	TYR197
B	TYR197
C	TYR197
D	TYR197
E	TYR197
F	TYR197
G	TYR197
H	TYR197
I	TYR197
J	TYR197

---

site_id	SWS_FT_FI17
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	SER198
B	SER198
C	SER198
D	SER198
E	SER198
F	SER198
G	SER198
H	SER198
I	SER198
J	SER198

---

site_id	SWS_FT_FI18
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER199
B	SER199
C	SER199
D	SER199
E	SER199
F	SER199
G	SER199
H	SER199
I	SER199
J	SER199

---

site_id	SWS_FT_FI19
Number of Residues	10
Details	MOD_RES: Phosphoserine; by CK1, PDPK1 and TTBK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER202
B	SER202
C	SER202
D	SER202
E	SER202
F	SER202
G	SER202
H	SER202
I	SER202
J	SER202

---

site_id	SWS_FT_FI20
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179

Chain	Residue	Details
A	THR205
B	THR205
C	THR205
D	THR205
E	THR205
F	THR205
G	THR205
H	THR205
I	THR205
J	THR205

---

site_id	SWS_FT_FI21
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	THR212
B	THR212
C	THR212
D	THR212
E	THR212
F	THR212
G	THR212
H	THR212
I	THR212
J	THR212

---

site_id	SWS_FT_FI22
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER214
B	SER214
C	SER214
D	SER214
E	SER214
F	SER214
G	SER214
H	SER214
I	SER214
J	SER214

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179

Chain	Residue	Details
A	THR217
B	THR217
C	THR217
D	THR217
E	THR217
F	THR217
G	THR217
H	THR217
I	THR217
J	THR217

---

site_id	SWS_FT_FI24
Number of Residues	20
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS225
A	LYS290
B	LYS225
B	LYS290
C	LYS225
C	LYS290
D	LYS225
D	LYS290
E	LYS225
E	LYS290
F	LYS225
F	LYS290
G	LYS225
G	LYS290
H	LYS225
H	LYS290
I	LYS225
I	LYS290
J	LYS225
J	LYS290

---

site_id	SWS_FT_FI25
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by GSK3-beta and PDPK1 => ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR231
B	THR231
C	THR231
D	THR231
E	THR231
F	THR231
G	THR231
H	THR231
I	THR231
J	THR231

---

site_id	SWS_FT_FI26
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER235
B	SER235
C	SER235
D	SER235
E	SER235
F	SER235
G	SER235
H	SER235
I	SER235
J	SER235

---

site_id	SWS_FT_FI27
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER237
B	SER237
C	SER237
D	SER237
E	SER237
F	SER237
G	SER237
H	SER237
I	SER237
J	SER237

---

site_id	SWS_FT_FI28
Number of Residues	10
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS259
B	LYS259
C	LYS259
D	LYS259
E	LYS259
F	LYS259
G	LYS259
H	LYS259
I	LYS259
J	LYS259

---

site_id	SWS_FT_FI29
Number of Residues	10
Details	MOD_RES: Phosphoserine; by MARK1, MARK2, MARK3, MARK4, BRSK1, BRSK2 and PHK => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER262
B	SER262
C	SER262
D	SER262
E	SER262
F	SER262
G	SER262
H	SER262
I	SER262
J	SER262

---

site_id	SWS_FT_FI30
Number of Residues	20
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER285
A	SER352
B	SER285
B	SER352
C	SER285
C	SER352
D	SER285
D	SER352
E	SER285
E	SER352
F	SER285
F	SER352
G	SER285
G	SER352
H	SER285
H	SER352
I	SER285
I	SER352
J	SER285
J	SER352

---

site_id	SWS_FT_FI31
Number of Residues	30
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:7706316

Chain	Residue	Details
A	SER293
A	SER324
A	SER356
B	SER293
B	SER324
B	SER356
C	SER293
C	SER324
C	SER356
D	SER293
D	SER324
D	SER356
E	SER293
E	SER324
E	SER356
F	SER293
F	SER324
F	SER356
G	SER293
G	SER324
G	SER356
H	SER293
H	SER324
H	SER356
I	SER293
I	SER324
I	SER356
J	SER293
J	SER324
J	SER356

---

site_id	SWS_FT_FI32
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PHK => ECO:0000269|PubMed:7706316, ECO:0000269|PubMed:8999860

Chain	Residue	Details
A	SER305
B	SER305
C	SER305
D	SER305
E	SER305
F	SER305
G	SER305
H	SER305
I	SER305
J	SER305

---

site_id	SWS_FT_FI33
Number of Residues	10
Details	MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER396
B	SER396
C	SER396
D	SER396
E	SER396
F	SER396
G	SER396
H	SER396
I	SER396
J	SER396

---

site_id	SWS_FT_FI34
Number of Residues	10
Details	MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER400
B	SER400
C	SER400
D	SER400
E	SER400
F	SER400
G	SER400
H	SER400
I	SER400
J	SER400

---

site_id	SWS_FT_FI35
Number of Residues	10
Details	MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER404
B	SER404
C	SER404
D	SER404
E	SER404
F	SER404
G	SER404
H	SER404
I	SER404
J	SER404

---

site_id	SWS_FT_FI36
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15546861, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER409
B	SER409
C	SER409
D	SER409
E	SER409
F	SER409
G	SER409
H	SER409
I	SER409
J	SER409

---

site_id	SWS_FT_FI37
Number of Residues	10
Details	MOD_RES: Phosphoserine; by CaMK2 and TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	SER416
B	SER416
C	SER416
D	SER416
E	SER416
F	SER416
G	SER416
H	SER416
I	SER416
J	SER416

---

site_id	SWS_FT_FI38
Number of Residues	10
Details	MOD_RES: Phosphoserine; by PDPK1 and TTBK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16923168, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189

Chain	Residue	Details
A	SER422
B	SER422
C	SER422
D	SER422
E	SER422
F	SER422
G	SER422
H	SER422
I	SER422
J	SER422

---

site_id	SWS_FT_FI39
Number of Residues	10
Details	MOD_RES: Phosphothreonine; by TTBK1 => ECO:0000269|PubMed:16923168

Chain	Residue	Details
A	THR427
B	THR427
C	THR427
D	THR427
E	THR427
F	THR427
G	THR427
H	THR427
I	THR427
J	THR427

---

site_id	SWS_FT_FI40
Number of Residues	130
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS-230
A	LYS66
A	LYS150
A	LYS163
A	LYS174
A	LYS225
A	LYS234
A	LYS259
A	LYS280
A	LYS281
A	LYS347
A	LYS353
A	LYS369
B	LYS-230
B	LYS66
B	LYS150
B	LYS163
B	LYS174
B	LYS225
B	LYS234
B	LYS259
B	LYS280
B	LYS281
B	LYS347
B	LYS353
B	LYS369
C	LYS-230
C	LYS66
C	LYS150
C	LYS163
C	LYS174
C	LYS225
C	LYS234
C	LYS259
C	LYS280
C	LYS281
C	LYS347
C	LYS353
C	LYS369
D	LYS-230
D	LYS66
D	LYS150
D	LYS163
D	LYS174
D	LYS225
D	LYS234
D	LYS259
D	LYS280
D	LYS281
D	LYS347
D	LYS353
D	LYS369
E	LYS-230
E	LYS66
E	LYS150
E	LYS163
E	LYS174
E	LYS225
E	LYS234
E	LYS259
E	LYS280
E	LYS281
E	LYS347
E	LYS353
E	LYS369
F	LYS-230
F	LYS66
F	LYS150
F	LYS163
F	LYS174
F	LYS225
F	LYS234
F	LYS259
F	LYS280
F	LYS281
F	LYS347
F	LYS353
F	LYS369
G	LYS-230
G	LYS66
G	LYS150
G	LYS163
G	LYS174
G	LYS225
G	LYS234
G	LYS259
G	LYS280
G	LYS281
G	LYS347
G	LYS353
G	LYS369
H	LYS-230
H	LYS66
H	LYS150
H	LYS163
H	LYS174
H	LYS225
H	LYS234
H	LYS259
H	LYS280
H	LYS281
H	LYS347
H	LYS353
H	LYS369
I	LYS-230
I	LYS66
I	LYS150
I	LYS163
I	LYS174
I	LYS225
I	LYS234
I	LYS259
I	LYS280
I	LYS281
I	LYS347
I	LYS353
I	LYS369
J	LYS-230
J	LYS66
J	LYS150
J	LYS163
J	LYS174
J	LYS225
J	LYS234
J	LYS259
J	LYS280
J	LYS281
J	LYS347
J	LYS353
J	LYS369

---

site_id	SWS_FT_FI41
Number of Residues	20
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:21327254

Chain	Residue	Details
A	SER208
A	SER238
B	SER208
B	SER238
C	SER208
C	SER238
D	SER208
D	SER238
E	SER208
E	SER238
F	SER208
F	SER238
G	SER208
G	SER238
H	SER208
H	SER238
I	SER208
I	SER238
J	SER208
J	SER238

---

site_id	SWS_FT_FI42
Number of Residues	10
Details	CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254

Chain	Residue	Details
A	SER400
B	SER400
C	SER400
D	SER400
E	SER400
F	SER400
G	SER400
H	SER400
I	SER400
J	SER400

---

site_id	SWS_FT_FI43
Number of Residues	30
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS-273
A	LYS267
A	LYS375
B	LYS-273
B	LYS267
B	LYS375
C	LYS-273
C	LYS267
C	LYS375
D	LYS-273
D	LYS267
D	LYS375
E	LYS-273
E	LYS267
E	LYS375
F	LYS-273
F	LYS267
F	LYS375
G	LYS-273
G	LYS267
G	LYS375
H	LYS-273
H	LYS267
H	LYS375
I	LYS-273
I	LYS267
I	LYS375
J	LYS-273
J	LYS267
J	LYS375

---

site_id	SWS_FT_FI44
Number of Residues	110
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS259
A	LYS281
A	LYS298
A	LYS317
A	LYS321
A	LYS331
A	LYS343
A	LYS347
A	LYS369
A	LYS385
B	LYS259
B	LYS281
B	LYS298
B	LYS317
B	LYS321
B	LYS331
B	LYS343
B	LYS347
B	LYS369
B	LYS385
C	LYS259
C	LYS281
C	LYS298
C	LYS317
C	LYS321
C	LYS331
C	LYS343
C	LYS347
C	LYS369
C	LYS385
D	LYS259
D	LYS281
D	LYS298
D	LYS317
D	LYS321
D	LYS331
D	LYS343
D	LYS347
D	LYS369
D	LYS385
E	LYS259
E	LYS281
E	LYS298
E	LYS317
E	LYS321
E	LYS331
E	LYS343
E	LYS347
E	LYS369
E	LYS385
F	LYS259
F	LYS281
F	LYS298
F	LYS317
F	LYS321
F	LYS331
F	LYS343
F	LYS347
F	LYS369
F	LYS385
G	LYS259
G	LYS281
G	LYS298
G	LYS317
G	LYS321
G	LYS331
G	LYS343
G	LYS347
G	LYS369
G	LYS385
H	LYS259
H	LYS281
H	LYS298
H	LYS317
H	LYS321
H	LYS331
H	LYS343
H	LYS347
H	LYS369
H	LYS385
I	LYS259
I	LYS281
I	LYS298
I	LYS317
I	LYS321
I	LYS331
I	LYS343
I	LYS347
I	LYS369
I	LYS385
J	LYS259
J	LYS281
J	LYS298
J	LYS317
J	LYS321
J	LYS331
J	LYS343
J	LYS347
J	LYS369
J	LYS385

---

site_id	SWS_FT_FI45
Number of Residues	30
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau => ECO:0000269|PubMed:16443603

Chain	Residue	Details
A	LYS254
A	LYS311
A	LYS353
B	LYS254
B	LYS311
B	LYS353
C	LYS254
C	LYS311
C	LYS353
D	LYS254
D	LYS311
D	LYS353
E	LYS254
E	LYS311
E	LYS353
F	LYS254
F	LYS311
F	LYS353
G	LYS254
G	LYS311
G	LYS353
H	LYS254
H	LYS311
H	LYS353
I	LYS254
I	LYS311
I	LYS353
J	LYS254
J	LYS311
J	LYS353

---