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9AYB

Structure of Apo Sialin S61A mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0005351molecular_functioncarbohydrate:proton symporter activity
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006820biological_processmonoatomic anion transport
A0006865biological_processamino acid transport
A0009617biological_processresponse to bacterium
A0015136molecular_functionsialic acid transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015538molecular_functionsialic acid:proton symporter activity
A0015739biological_processsialic acid transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0022857molecular_functiontransmembrane transporter activity
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0034219biological_processcarbohydrate transmembrane transport
A0042874biological_processD-glucuronate transmembrane transport
A0042880molecular_functionD-glucuronate transmembrane transporter activity
A0045202cellular_componentsynapse
A0055085biological_processtransmembrane transport
A0098700biological_processneurotransmitter loading into synaptic vesicle
A0098978cellular_componentglutamatergic synapse
A1902600biological_processproton transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU42-VAL62
AALA392-ILE412
AILE424-ALA444
ATHR458-ALA478
ATRP110-ALA130
AMET137-ALA157
ALEU159-PHE179
AILE201-CYS221
ATYR228-VAL248
AVAL280-SER300
APHE329-ALA349
AILE366-GLY386

site_idSWS_FT_FI2
Number of Residues95
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
AALA63-GLY109
AASP158
ATYR222-THR227
ATYR301-GLY328
ACYS387-LEU391
ALYS445-GLN457

site_idSWS_FT_FI3
Number of Residues96
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ASER131-LYS136
APRO180-SER200
ASER249-SER279
AASP350-ARG365
AASN413-GLY423
ALYS479-HIS495

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER3

site_idSWS_FT_FI5
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN71
AASN77
AASN95

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PDB entries from 2024-12-18

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