9AVG

Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0001750	cellular_component	photoreceptor outer segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007213	biological_process	G protein-coupled acetylcholine receptor signaling pathway
B	0007265	biological_process	Ras protein signal transduction
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0070062	cellular_component	extracellular exosome
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	0071870	biological_process	cellular response to catecholamine stimulus
B	0097381	cellular_component	photoreceptor disc membrane
B	1903561	cellular_component	extracellular vesicle
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0045202	cellular_component	synapse
G	0048144	biological_process	fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus
Q	0004930	molecular_function	G protein-coupled receptor activity
Q	0007186	biological_process	G protein-coupled receptor signaling pathway
Q	0016020	cellular_component	membrane
R	0004930	molecular_function	G protein-coupled receptor activity
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

---

site_id	PS00979
Number of Residues	19
Details	G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS

Chain	Residue	Details
Q	VAL153-SER171

---

site_id	PS00980
Number of Residues	25
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC

Chain	Residue	Details
Q	CYS561-CYS585

---

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM

Chain	Residue	Details
Q	PHE801-MET811

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	62
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	270
Details	Region: {"description":"Ligand-binding 2 (LB2)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	140
Details	Region: {"description":"Cysteine-rich (CR)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	22
Details	Region: {"description":"Intracellular loop 1 (ICL1)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	30
Details	Region: {"description":"Intracellular loop 3 (ICL3)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Site: {"description":"Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity","evidences":[{"source":"PubMed","id":"26290606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18434541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22383884","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"20213681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P10824","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---